C&P#121: cannabis for fibro, cancer & chronic pain + negatives for fertility
Lex Pelger
'Cannabinoids & the People' newsletter on Substack + canna-edu vids on YT @cannabinoidsandthepeople + the Moby Dick pot books (graphic novels on cannabis)
[As always, for the best formatting, see the edition on Substack:
https://www.cannabinoidsandthepeople.whitewhalecreations.com/p/c-and-p121-cannabis-for-fibro-cancer]
This week…
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Hello everyone,
Welcome to the 121st edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science + assorted canna-news & psychedelic updates. Upgrade to a paid subscription here to support my work sharing canna-science. On the cannabinoids, ask me anything.
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Long videos:
Short videos:
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Best Of Cannabinoid Science...
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On the new Cannabis & Health Research Initiative for integrating cannabis into healthcare
The Cannabis and Health Research Initiative
And oh yes, you better believe I pitched them with my services. Let me newsletter, science archive, video edu & podcast for you!
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Clinical
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In an observational study of people beginning medical cannabis, after one year they had significant reductions in pain scores, less interference of pain on daily function & improvements to sleep & mental health (depression, anxiety, stress)
Changes in Pain and Mental Health Symptoms Associated with Prescribed Medicinal Cannabis Use: A One-Year Longitudinal Study
And in an economic analysis of treating chronic pain, because cannabinoid based medicines had similar efficacy to other treatments but were less expensive, they were found to be “significantly more cost-effective”
An early economic analysis of medical cannabis for the treatment of chronic pain
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In people with fibromyalgia, analysis of different cannabis products found improvements in anxiety, sleep, fibromyalgia symptom severity & quality of life with no differences across the formulations
Comparison of Cannabis-Based Medicinal Product Formulations for Fibromyalgia: A Cohort Study
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For improving sleep, a company-sponsored analysis found their oral CBN products (at 25 to 100 mg) to be as effective as melatonin, with the 100 milligrams of CBN also causing a significant decrease in stress
A Randomized, Double-Blind, Placebo-Controlled Trial to Assess the Effectiveness and Safety of Melatonin and Three Formulations of Floraworks Proprietary TruCBN? for Improving Sleep
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In people being treated with CBD for their drug-resistant focal epilepsy, they also experienced improvements to their psychiatric comorbidities, depression & anxiety
Psychiatric comorbidities before and after cannabidiol treatment in adult patients with drug resistant focal epilepsy
And in a rat model of seizures, vaporized CBD & oral THC reduced their seizure-induced increases in anxiety & fear responses, probably via serotonin receptors
Phytocannabinoids restore seizure-induced alterations in emotional behaviour in male rats
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In humans smoking cannabis, an analysis of their THC exposure via their blood concentrations
Dose Estimation Utility in a Population Pharmacokinetic Analysis of Inhaled Δ9-Tetrahydrocannabinol Cannabis Market Products in Occasional and Daily Users
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In public health data, cannabis use in early pregnancy not associated with childhood autism
Maternal Prenatal Cannabis Use and Child Autism Spectrum Disorder
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To mimic the benefits of fasting in healthy young adults, a mixture of PEA, spermidine, nicotinamide & oleoylethanolamide (the anti-hunger endocannabinoid found in the PlusCBD ReShape products)
Absorption, Anti-inflammatory, Antioxidant, and Cardioprotective Impacts of a Novel Fasting Mimetic Containing Spermidine, Nicotinamide, Palmitoylethanolamide, and Oleoylethanolamide: A Pilot Dose-Escalation Study in Healthy Young Adult Men
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In six cases of dogs with accidental THC ingestion, they were primarily treated with transmucosal CBD & their clinical signs resolved with 45 minutes
Case Report: Treatment of non-medical tetrahydrocannabinol toxicosis with transmucosal cannabidiol-infused dissolving sheets in six dogs
https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2024.1448123/abstract
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Harms
(for reproductive harms, there’s so many this week that they’re all grouped together below in the ‘Reproduction & Hormones’ section)
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For developing psychosis, a review of the role of cannabis
The Role of Cannabis in the Development of Psychosis
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In public health data, more respiratory symptoms were found in people smoking cannabis or cigarettes but not for people vaping nicotine or cannabis
Assessing the Association between Respiratory Symptoms, Nicotine and Cannabis Use via Traditional and E-product Devices in the United States
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For cancer risk, a review with suggestive evidence of the link between cannabis use & testicular cancer
Cancer risk and legalisation of access to cannabis in the USA: overview of the evidence
“The cancer type most closely linked to cannabis use is non-seminoma testicular cancer. However, evidence is emerging of an increased risk of other types of cancer (eg, lung squamous cell carcinoma, head and neck squamous cell carcinoma, and oral, breast, liver, cervical, laryngeal, pancreatic, thyroid, and childhood cancer).”
There’s been some quite solid public health data out of Europe confirming the small but real link between cannabis use & cancer, most especially testicular.
(so when I found a lump earlier this year, whew, you can know that I got the fears. But it turned out to be nothing)
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For prenatal cannabis exposure, a review of the alterations to neurodevelopment
Implications of Prenatal Cannabis Exposure on Childhood Neurodevelopmental Outcomes: A Summary of the Clinical Evidence
“Limited data have shown associations between intrauterine cannabis exposure and (1) increased startles and difficulty with consolation in the neonatal period, (2) memory challenges, verbal reasoning challenges, and diminished academic performance during early childhood, and (3) inattention, hyperactivity, and aggression during early childhood.”
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In youth exposed to cannabis prenatally, public health data of brain scans found an association with psychotic-like experiences & blunted neural response to reward anticipation (a predictor of psychosis symptomatology)
Altered neurobehavioral reward response predicts psychotic-like experiences in youth exposed to cannabis prenatally
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In genetic studies, a genetic prediction for cannabis use disorder was associated with an increased risk of stroke, migraines with aura & Alzheimer's disease, with a possible involvement of the brain-gut axis
Cannabis use disorder increases risk of large-artery atherosclerotic stroke and migraine with aura through mendelian randomization study
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In France, an analysis of the negatives of cannabis from their medical cannabis experiment
The contribution of addictovigilance data to the French medical cannabis experimentation
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In people having carpal tunnel release surgery, those with a cannabis-related disorder had greater rates of post-operative opioid prescriptions & emergency department visits
Cannabis-Related Disorders Are Associated with Increased Early Postoperative Opioid Prescriptions and Delayed Emergency Department Visits Following Open Carpal Tunnel Release
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A case report of cannabis hyperemesis syndrome
Cannabis hyperemesis syndrome: Case report
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Reviews
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In oncology, a review of the anti-tumor effects & patient benefits of cannabis (sexy cancer charts)
The Efficacy of Cannabis in Oncology Patient Care and Its Anti-Tumor Effects
And a review of using cannabis for the pain of cancer
Harnessing Cannabis: Pain Management Strategies for Oncology Patients – A Narrative Review
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In Alzheimer's disease, a review of 22 studies on how CBD disrupts the formation of the Aβ plaques, reduced the release of pro-inflammatory molecules, prevented the formation of reactive oxygen species, inhibited oxidation of lipids & protected the neurons from apoptosis (programmed cellular suicide)
A systematic study of molecular targets of cannabidiol in Alzheimer’s disease
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For psoriasis, a review of treating with CBD oil
Exploring the Potential of Cannabidiol (CBD) Oil as an Adjunct Therapy for Psoriasis: Efficacy, Mechanisms, and Regulatory Challenges
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A review of the benefits of PEA
Palmitoylethanolamide, an endogenous fatty acid amide, and its pleiotropic health benefits: A narrative review
Or read my article from last year on ProjectCBD: PEA: Anti-Inflammatory Superstar
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For organ fibrosis (scarring), a review on targeting the CB2 receptors (with two great charts!)
Therapeutic potential of agents targeting cannabinoid type 2 receptors in organ fibrosis
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For brain development, a review of the endocannabinoid systems involvement from embryogenesis to adolescence (nice charts)
Cannabis, Endocannabinoids and Brain Development: From Embryogenesis to Adolescence
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For stress of the endoplasmic reticulum (protein processing center of the cell), a review paper on utilizing the endocannabinoid system
Exploring Endocannabinoid System: Unveiling New Roles in Modulating ER Stress
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Preclinical
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In a mouse safety study of vaping CBD & propylene glycol, there were no negative effects until the highest doses were used (well over the typical levels found in over-the-counter vape products)
Biological Response after 14-Day Cannabidiol and Propylene Glycol Inhalation in Sprague–Dawley Rats
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In a mouse model of fever, CBD suppressed fever & pro-inflammatory cytokine levels via the HPA axis & inflammatory reflex
Cannabidiol exerts antipyretic effects by downmodulating inflammatory mediators in LPS-induced fever
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In a mouse model of depression, cannabis extract improved depressive behaviors & reduced systemic inflammation probably via the mast cells (immunoregulatory cells)
Antidepressant-like Effects of Cannabis sativa L. Extract in an Lipopolysaccharide Model: Modulation of Mast Cell Activation in Deep Cervical Lymph Nodes and Dura Mater
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In the offspring of mice with maternal obesity, CBD helped to lessen the associated neuroinflammation, anxiety, social disturbances & endocannabinoid signaling
Cannabidiol partially rescues behavioral, neuroinflammatory and endocannabinoid dysfunctions stemming from maternal obesity in the adult offspring
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In a mouse model of opioid tolerance, PEA delayed the formation of tolerance & potentiated its painkilling effects via downregulation of VEGF-A & sFLT-1
New insights in the mechanisms of opioid analgesia and tolerance: Ultramicronized palmitoylethanolamide down-modulates vascular endothelial growth factor-A in the nervous system
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In a mouse model of alcohol use disorder, oleoylethanolamide (the “anti-hunger” endocannabinoid) reduced alcohol self-administration, addiction cue behaviors & the number of sessions needed for the extinction of alcohol seeking
Region-Specific Gene Expression Changes Associated with Oleoylethanolamide-Induced Attenuation of Alcohol Self-Administration
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In a tissue & mouse model of asthma, CBD extracts inhibited inflammation & down regulated proinflammatory & pro-asthmatic cytokines as well as modulating immune cell behavior
High-CBD Extract (CBD-X) in Asthma Management: Reducing Th2-Driven Cytokine Secretion and Neutrophil/Eosinophil Activity
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In skin stem cells, CBD enhanced their antioxidant properties to protect from UVB radiation
3-O-Ethyl Ascorbic Acid and Cannabigerol in Modulating the Phospholipid Metabolism of Keratinocytes
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For candida, the antifungal effects of CBD
Effect of Cannabidiol (CBD), a cannabis plant derivative, against Candida albicans growth and biofilm formation
As someone with a wife & firstborn child with an annoying candida infection in their mouth right now, I'm glad to be sharing this research.
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Novel Studies
(my new grab bag section for stuff I haven’t quite seen before)
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For trans people who want to develop their breasts, an argument for using cannabinoids to induce gynecomastia (the process of male breast tissue development due to hormone imbalance)
Th e escamotages to maintain glamour and turgidity e escamotages to maintain glamour and turgidity in breast of MtF transexual individuals by the aids of n breast of MtF transexual individuals by the aids of cannabinoids and unripe tomatoes annabinoids and unripe tomatoes
This one seems like a stretch, but it’s too fascinating not to share.
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In a diary study of relationships, while the light use of cannabis had no effect on relationship satisfaction, heavy users & those who co-used alcohol & cannabis had reductions in their next-day relationship satisfaction
Dyadic cannabis use, alcohol use and relationship satisfaction: A daily diary study
Surprisingly, alcohol-only use was significantly associated with increased next-day satisfaction.
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In Colorado commercial cannabis, the levels of heavy metal contamination
Levels and Distribution of Health-Relevant Heavy Metals in Commercially Grown Cannabis in Colorado
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An analysis of 500k US cannabis product listings & their flavors
Cannabis-Derived Product Types, Flavors, and Compound Types From an E-Commerce Website
And in San Diego, what derived cannabinoid products can be bought from vape shops
Derived cannabinoid product availability among online vape shops
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In cannabis stems & roots (which were quite widely used in world history), a computer analysis of the pathways most likely to be activated by their components
A Study of the Predictive Effectiveness of Stem and Root Extracts of Cannabissativa L. Through Network Pharmacological Analysis
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In steers, characterizing their endocannabinoid system
The endocannabinoid system in bovine tissues: characterization of transcript abundance in the growing Holstein steer
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the Headlines & Fav Articles
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My election take:
Well, this election cycle was about as bad as it can get for cannabis:
Florida voted no for legal cannabis. As did North & South Dakota.
Trump considers cannabis to be a state’s rights issue & so probably no federal changes will occur such as tax relief from the dreaded 280E. And rescheduling probably won’t move forward, not that it ever mattered much anyway (In fact, a DEA judge just delayed the rescheduling hearing until early next year).
The only good news is that Nebraska voted yes for medical. So thanks to all the hardworking activists who made that happen & allowed the people of the Cornhusker state to get their medicine.
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Allegations against Curaleaf of sexual harassment by former Senior Vice President Khadijah Tribble
“Tribble’s lengthy list of grievances includes:
- Learning that she was making “significantly less” than “white male peers” at the company.
- Enduring sexual harassment from another company vice president while in the presence of her own subordinates.
- Hearing Executive Chairman Boris Jordan use “racist” language to describe those with criminal cannabis convictions and immigrants.
- Receiving a death threat from a vendor, which led directly to serious mental health issues for Tribble.
- Retaliation by Curaleaf executives against her for reporting the above problems to human resources or other company leaders”
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According to NORML, FBI cannabis-related arrest made up 40% of all drug arrests in a dozen states in 2023
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A record number of banks now working with cannabis businesses according to new data from the federal Financial Crimes Enforcement Network (FinCEN)
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In Florida, the large MSOs have largely stopped producing low-THC/high-CBD products for the medical market to focus on high-THC market for the legal market (which got voted down), leaving patients in need of their preferred medicine
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The workers most likely to be using cannabis are in food service, entertainment & construction according to a new federal report
“Among those least likely to report marijuana use, meanwhile, were law enforcement, health care providers and workers in libraries and education.”
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Nevada athletic officials to stop punishing boxers & MMA fighters over cannabis use
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An interview with the journalist Chris Faraone of Talking Joints Memo
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Ha! An economic analysis between Colorado & Utah found an increased household expenditure of $898 post-legalization
Evaluating the Economic Impact of Marijuana Legalization: A Difference-in-Differences and Regression Analysis of Household Expenditures in Colorado and Utah
The best money spent!
My wife would be miserable if I never spent money down by the river.
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International
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In Thailand, interviews with unlicensed medical cannabis providers
Views and practices on medical cannabis of unlicensed providers in Thailand: a qualitative study
“Overall, six reasons were identified to answer why unlicensed/illicit providers were still popular, including: 1) easy accessibility; 2) familiarity with the unlicensed providers before the legal scheme became available; 3) favorable characters (kind, supportive, non-judgmental) of unlicensed providers; 4) affordable treatment fees; 5) trust in the quality of the medicines; and 6) lack of knowledge and negative attitudes towards cannabis from healthcare professionals. Most providers started their career as medical cannabis providers by using it themselves or with their relatives and being satisfied with the results. They used cannabis products to treat all diseases, including skin, eyes, HIV/AIDS, non-communicable diseases and all kinds of cancers.”
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A German study finds high level of contamination in underground cannabis
“Of over 253 samples tested, only 74 were deemed safe and clean. The remaining samples contained harmful contaminants, including human and animal feces, Covid-19, salmonella, influenza, and dangerous levels of illegal pesticides known to cause cancer and infertility, such as Pymetrozin, Paclobutrazol, Chlorfenapyr, Trifloxystrobin, and even hair spray.”
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On the Indonesian island of Aceh, interviews on their perspectives on cannabis
Pandangan Masyarakat Aceh tentang Penggunaan Ganja
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In New Zealand, an analysis of their medical cannabis scheme
Implementation of the Medicinal Cannabis Scheme in New Zealand: six emerging trends
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In Switzerland, an analysis of the social forces around the cannabis pilot trials
Social forces shaping evidence production: A study of the swiss cannabis pilot trials
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In Belgium, an analysis of the CBD food products market
THE MARKET OF CBD FOOD PRODUCTS IN BELGIUM: INSIGHTS INTO PUBLIC KNOWLEDGE, PERCEPTIONS, AND BEHAVIOUR
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The Laws, The War on Drugs & the End of Prohibition
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Among first-time arrestees in 25 county jails, an analysis of their drug use
Who’s Using What? An Investigation of Drug Use Among First-Time Arrestees from 25 County Jails Across the United States in 2023
“Of the 43,553 UDS cases comprising the final sample (28.8% of total arrestees), 74.8% were positive for one or more drugs, and 25.2% of UDS cases were negative for all drugs. Positivity was 69.0% for cannabis, 54.8% for stimulants, 29.6% for opioids, and 12.4% for sedatives. Arrestees were positive for multiple drugs half the time, with combinations of cannabis, stimulants, and opioids most common”
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Psychedelics, Plant Medicines & Other Psychoactives
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Massachusetts voters rejected a proposal to legalize psychedelic plant medicines
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Sexual abuse scandal with a head of the Santo Daime ayahuasca church, the psychologist & padrinho of the Céu do Mar temple in Rio de Janeiro, Paulo Roberto Souza e Silva
And an open letter from Jonathan Goldman, a church leader in Ashland, Oregon
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Mattha Busby on the death of a client at a neoshaman iboga psychedelic retreat in Costa Rica
And Mattha Busby on psychedelic mushrooms getting stronger with new breeding techniques & genetic technologies
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The Synaptic Institute, a training program for psychedelic facilitators, shut down after a glut of graduates couldn’t find employment
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The Plant & the History
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A history of cannabis in central India across the Holocene (the last ~12k years)
Understanding the presence of Cannabis across the Holocene in Central India
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Growing & Processing
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A protocol for aging cannabis to study cannabinoid stability
Development of an accelerated ageing protocol for the study of phytocannabinoid stability in Cannabis sativa L
领英推荐
Just show it the election results.
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An analysis of how different extraction techniques alter the cannabinoid & terpenoid content
Effect of Hemp Extraction Procedures on Cannabinoid and Terpenoid Composition
“Hydrodistilled extracts contained the most variety and abundance of terpenes with β-caryophyllene to be the most concentrated terpene (25-42 mg/g). Supercritical CO2 extracts displayed a minimal variety of terpenes, but the most variety and abundance of cannabinoids with CBD ranging from 12.8-20.6 mg/g. Ethanol extracts contained the most acidic cannabinoids with 3.2-4.1 mg/g of CBDA along with minor terpene levels.”
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From Japan, a new species of leaf spot pathogen on hemp: Septoria cannabis
Septoria cannabicola, a new species on Cannabis sativa from Japan
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In germinated hemp seeds, their metabolic & cannflavin profiles
Metabolic and cannflavin profiles of germinated hemp seed (Cannabis sativa L.)
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Using near-infrared & AI to analyze THC acid levels in cannabis flowers before harvest
Rapid In Situ Near-Infrared Assessment of Tetrahydrocannabinolic Acid in Cannabis Inflorescences before Harvest Using Machine Learning
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On a scalable regeneration tissue culture method for cannabis
Development of efficient and scalable regeneration tissue culture method for Cannabis sativa
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On mining of the cannabis genome
Research Progress in Genome Sequencing and Functional Gene Mining of Cannabis?
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Food & Nutrition
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In meat products, replacing animal fat & sodium nitrate with hemp seed oil improved the fatty acid composition & lipid quality nutritional index while maintaining other food parameters
Substitution of Animal Fat and Sodium Nitrite with Hemp Seed Oil: Effect on the Nutritional Value, Sensory Characteristics, and Shelf Life of Fermented Salami
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In dairy products, using CBD to slow the growth of listeria bacteria
ANTILISTERIAL ACTIVITY OF CBD FOR THE PREVENTION OF LISTERIA MONOCYTOGENES IN DAIRY PRODUCTS
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In grazing goats, hemp hay significantly increased milk production & changed the fatty acid profile
The Effects of Hemp Hay (Canapa sativa L.) in the Diets of Grazing Goats on Milk Production and Fatty Acid Profile
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In broiler chickens, feed supplementation with cannabis sativa has a “remarkable impact on the growth rate & development”
The effect of feed Supplementation with Cannabis sativa on the Growth rate and Development of Broiler Chicks
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In rabbits, adding hempseed cake to their food caused no negative effects on their reproduction or health status
The Effects of Adding Hempseed Cake on Sperm Traits, Body Weight, Haematological and Biochemical Parameters in Rabbit Males
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For hemp seeds, different extraction & dehydration methods & their effects
Effects of protein variations by different extraction and dehydration approaches on hempseed protein isolate: Protein pattern, amino acid profiling and label-free proteomics
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On extracting hemp seed oil with supercritical CO2
Ultrasound and low-pressure supercritical CO2 extraction: A synergistic approach to hemp seed oil extraction
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To analyze cannabinoid levels in meat products & animal feeds, using liquid chromatography-tandem mass spectrometry (LC-MS/MS)
Determination of Cannabinoids in Meat Products and Animal Feeds in Singapore Using Liquid Chromatography-Tandem Mass Spectrometry
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An analysis of hempseed cake waste
EXPLORING THE PHYSICOCHEMICAL PROPERTIES OF RECOVERED INDUSTRIAL HEMP SEED (CANNABIS SATIVA L.) CAKE WASTE
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Industrial Uses & Fiber
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On making a green adhesive from hemp shiv
Experimental Assessment of Hemp Shiv and Green Adhesives to Produce a Biocomposite Material
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Aerogels & cryogels from hemp waste
Hemp cellulose-based aerogels and cryogels: From waste biomass to sustainable absorbent pads for food preservation
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On contrasting the environmental impacts of bacterial versus thermochemical retting
Comparative Life Cycle Assessment of Bacterial and Thermochemical Retting of Hemp
“This work has demonstrated the advantages of the bacterial retting method from an environmental standpoint. The result of our research shows about a 24% gate-to-gate reduction in CED [cumulative energy demand] for bacterial retting and 20-25% lower environmental impacts relating to global warming, smog formation, acidification, carcinogenics, non-carcinogenics, respiratory effects, ecotoxicity, and fossil fuel depletion when compared to that of thermochemical retting.”
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For hemp fiber, the effects of water and moisture absorption on performance
An overview of the effects of water and moisture absorption on the performance of hemp fiber and its composites
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On the fiber properties of combining hemp with a polypropylene resin
Mechanical Properties of Natural Composites: Hemp Fiber and Polypropylene Resin
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CANNABINOID SCIENCE
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An Algerian review of the science of phytocannabinoids & their regulatory challenges
Phytocannabino?ds: Therapeutic potential, mechanism of action, and regulatory challenges
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A Korean review on breakthroughs in medical cannabis & shifting public perceptions
Medical Cannabis: From Research Breakthroughs to Shifting Public Perceptions and Ensuring Safe Use
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A German review on the health effects of cannabis
Health effects of cannabis
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Public Health
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Public health data on the most popular routes of cannabis administration in US adults & adolescents
The many forms of cannabis use: Prevalence and correlates of routes of administration among nationally representative samples of U.S. adult and adolescent cannabis users
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In Mexico, a survey on the opinions about medical & recreational cannabis use
Opinions on the Medical and Recreational Use and Legalization of Marijuana in Mexico: Results of a National Survey
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On developing a behavioral economic measure of cannabis use
Lessons Learned in Developing a Behavioral Economic Measure of Cannabis Use Using a Predominantly White Sample
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A call to action for professional communication researchers on better labeling for cannabis edibles
The Packaging and Labeling of Cannabis Edibles: Opportunities for Professional Communication Researchers
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American Journal of Public Health cannabis issue
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Intro to the implications for public health of current cannabis use in the US
Closing Gaps Between Cannabis Policy and Scientific Understanding
Current Cannabis Use in the United States: Implications for Public Health Research
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For children with accidental cannabis poisonings, lessons from monitoring adverse events for edible packaging policies
Monitoring Cannabis Adverse Events: Lessons From Edible Packaging Policies and Child Poisonings
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Monitoring adverse events from cannabinoid hemp products
The Food and Drug Administration’s Safety Surveillance of Adverse Event Cases Involving Cannabinoid Hemp Products, 2019–2023
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In Medicare beneficiaries, there's been an increase in cannabis related disorders
Trends in Medical Encounters Involving Cannabis-Related Disorders Among US Medicare Beneficiaries, 2017–2022
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For cannabis warning labels, the US regulatory landscape
Regulatory Landscape of Cannabis Warning Labels in US States with Legal Retail Nonmedical Cannabis, 2024
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On a model for understanding cannabis risks & promoting harm reduction
A Social-Ecological Model for Understanding Cannabis Risks and Promoting Harm Reduction
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On the US public health data on medical cannabis patients in state registry reports
Data Quality in State Registry Reports of Medical Cannabis Patients in the United States
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On how to improve studying the health effects of high-concentration THC products
Enhancing Methodological Approaches for Studying Health Effects of High-Concentration THC Products
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On how to improve cannabis policy research
Improving Cannabis Policy Research at a Pivotal Time for Policy Development
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In US workers in 15 states, a study of the prevalence of cannabis use
Prevalence of Cannabis Use Among US Workers in 15 States, 2016–2020
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Adolescents & Young Adults
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Contrary to expectations, higher levels of drug-related crime in a community were not associated with an increase in adolescent use of cannabis, tobacco or alcohol
Higher Neighborhood Crime Rates Don't Always Predict Early Initiation of Tobacco, Marijuana, and Alcohol
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In young adults who use nicotine & cannabis, an analysis of their routes of administration
Nicotine and cannabis routes of administration and dual use among U.S. young adults who identify as Hispanic, non-Hispanic Black, and non-Hispanic White
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In young adults, using momentary mindfulness or distraction coping messages to reduce cannabis cravings
Momentary mindfulness versus distraction coping messages to reduce cannabis craving among young adults: A microrandomized trial
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In the country of Georgia, the decriminalization of cannabis in 2018 caused only a minimal shift of cannabis use in young adults
Post-legalization shifts in cannabis use among young adults in Georgia—A nationally representative study
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In California, more protective cannabis policies and & less retail availability were associated with a lower prevalence of adolescent cannabis use & problematic cannabis use
Association of Local Cannabis Policy and Retail Availability With Cannabis Use and Problematic Cannabis Use Among Adolescents in Northern California
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In Native American youth, characterizing their cannabis use
Frequency is not enough: Characterizing heterogenous patterns of cannabis use intensity among reservation-area American Indian youth
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In Mississippi youth, the seven risky behaviors associated with cannabis use (“carrying weapons on school campuses, suicidal attempts, electronic vapor use, current smoking, current drinking, sexual behaviors & unsupervised children” [does this mean that they are unsupervised children or that they have unsupervised children?])
Cannabis Use and Associated Risk Behavior Factors among High School Students in Mississippi: Youth Risk Behavior Surveillance System 2021
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In Uganda & Kenya, psychological distress among young people using alcohol or cannabis
PSYCHOLOGICAL DISTRESS AMONG YOUNG PEOPLE WHO USE ALCOHOL OR CANNABIS IN UGANDA AND KENYA
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In youth experiencing homelessness, using AI to identify their cannabis use behaviors
Identifying Marijuana Use Behaviors Among Youth Experiencing Homelessness Using a Machine Learning–Based Framework: Development and Evaluation Study
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In adolescents, an analysis of their internalizing & externalizing behaviors & alcohol or cannabis use
The Association of Adolescent Internalizing and Externalizing Behavior Problems and Prospective Self with Alcohol and Cannabis Use
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The Brain & Neurological Disorders
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In people with Parkinson's disease, those with decreased levels of CB1 receptors had more problems with gait, postural instability & rigidity
Impaired Gait, Postural Instability, and Rigidity in Relation to CB1 Receptor Availability in Parkinson's Disease
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In people with mild cognitive impairment (a precursor to Alzheimer's disease), a survey on why they would & would not be interested in a trial of CBD
The proof is in the pudding: Patient Engagement in Studying Cannabidiol in Mild Cognitive Impairment
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In mice with no CB1 receptors on a class of their interneurons, they had partial hearing loss & abnormal auditory brainstem response
Conditional deletion of CB1 receptor in parvalbumin-expressing GABAergic neurons results in partial hearing loss and abnormal auditory brainstem response in mice
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In mice without the enzyme DAGLα (which synthesizes 2-AG) in their cerebellum (motor & social behavior area), they had disrupted short-term synaptic plasticity, reduced activity during social exploration as well as alterations to their motor & social behaviors
Deletion of endocannabinoid synthesizing enzyme DAGLα from cerebellar Purkinje cells decreases social preference and elevates anxiety
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In a rat model of poisoning by Bisphenol A, the terpene beta caryophyllene protected the brain from the oxidative stress damage
Neuroprotective Efficacy of β-caryophyllene on Cerebellar Changes Caused by Bisphenol A in Rats via Alleviating Oxidative Stress
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Mental Health, Addiction & Cannabis Use Disorder
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In people with serious mental illness in Canada, one-third of them were using cannabis and it was associated with adverse clinical outcomes
Clinical and public safety risks associated with cannabis legalization and frequency of cannabis use among forensic mental health patients
“Frequency of use was lower in the pre-legalization period, and then gradually and significantly increased after legalization. Compared to patients with no cannabis use, those with one or more instances of use were more likely to be readmitted to hospital and had higher rated static risk factors for violence. However, there were no observed differences in the actual rate of violence between patients using and not using cannabis, nor differences in the rate of violence over time. Over half of the patients who used cannabis experienced a worsening of their mental health status in the week following use.”
All of this being said, as we see in so many diseases, the people most likely to be using cannabis are the ones in the worst shape. One might guess that it's because they are the most motivated to try anything that helps. But perhaps sometimes, especially for mental health, the cannabis is indeed making things worse.
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Pain, Musculoskeletal & Surgeries
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On the potential of treating pain with positive allosteric modulators of the CB1 receptor (a property of CBD)
Could positive allosteric modulators of the cannabinoid CB1 receptor be efficacious and safe for the treatment of chronic pain?
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In cats having a hysterectomy, CBD did not cause great changes to pain scores but decreased the need for fentanyl during the operation
Perioperative Analgesic and Sedative Effects of Cannabidiol in Cats Undergoing Ovariohysterectomy
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Guts, Metabolism & Oral Health
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In Arkansas public health data, people with medical cannabis cards were significantly less likely to experience the overuse of antiemetics (antinausea medications)
Association Between Medical Marijuana Cardholder Status and Antiemetic Overuse
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Immune System & Microbial
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In people smoking cannabis, they had lower levels of neutrophils & a higher distribution in the size of their platelets
Effect of cannabis smoking on some hematological parameters among smokers in Khartoum city
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Reproduction & Hormones
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In women presenting to a fertility center, cannabis use was associated with a lower ovarian reserve
MARIJUANA SMOKING AND OVARIAN RESERVE AMONG FEMALES PRESENTING TO AN ACADEMIC FERTILITY CENTER
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In people undergoing IVF treatment, while THC was not associated with changes to egg maturation or embryo development, it seemed to make there be fewer embryos available to transfer
CANNABIS CONSUMPTION REDUCES THE NUMBER OF EUPLOID EMBRYOS AVAILABLE FOR TRANSFER: A RETROSPECTIVE STUDY
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In couples with infertility using cannabis, they had a significantly higher reported rates of anxiety, depression & being on at least one psychiatric medication than couples not using cannabis
IS CANNABIS USE ASSOCIATED WITH A PSYCHIATRIC DIAGNOSIS IN COUPLES WITH INFERTILITY?
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In toddlers with prenatal tobacco or cannabis exposure as well as maternal anger & unpredictability, they had increased reactivity
Prenatal tobacco and tobacco-Cannabis co-exposure and unpredictability in maternal anger/hostility: Implications for toddler reactivity
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In California since 2012, the levels of prenatal cannabis use have been increasing to 9% in 2022
Changes in Prenatal Cannabis Use Among Pregnant Individuals From 2012 to 2022
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In human placental cells, THC lessened the process of syncytialization (formation of the syncytium that comprises the materno-fetal interface), reduced hormone production & lowered function of the mitochondria (powerhouse of the cell)
Delta-9-tetrahydrocannabinol disrupts mitochondrial function and attenuates syncytialization in human placental BeWo cells
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In a rat model of erectile dysfunction induced by THC, extract of Kigelia Africana (the sausage tree) improved sperm production & enhanced libido
SPERMATOGENIC AND LIBIDO ENHANCING EFFECT OF ETHANOL EXTRACT OF KIGELIA AFRICANA IN ? 9 TETRAHYDROCANNABINOL INDUCED ERECTILE DYSFUNCTION IN MALE WISTAR RATS
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The Heart
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In people with carotid artery calcification, their usage of cannabis had no association with the prevalence of plaque on the carotid (key artery of head & neck)
Regular cannabis smoking and carotid artery calcification in the Multi-Ethnic Study of Atherosclerosis (MESA)
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In a rat model of loss of blood flow to the heart, CBD & β-adrenoceptor stimulation protected against the damages of reoxygenation
Comparison of Cardioprotective Potential of Cannabidiol and β-Adrenergic Stimulation Against Hypoxia/Reoxygenation Injury in Rat Atria and Ventricular Papillary Muscles
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Cancer & Chemotherapy
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In prostate cancer, CBD suppressed metastasis via modulation of tryptophan catabolism
Cannabidiol Suppresses Metastatic Castration-Resistant Prostate Cancer Progression and Recurrence through Modulating Tryptophan Catabolism
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In liver cancer, the protective effects of CBD oil
Protective and therapeutic effects of Cannabidiol oil on Hepatocellular carcinoma (HCC) induced by dimethylnitrosamine (DENA) in male rats
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The anti-cancer effects of ring analogs of CBD
Discovery of Ring-Annulated Analogues of Cannabidiol as Potential Anticancer Agents: Synthesis and Biological Evaluation
There has to be a Lord of the Rings joke to be made here but I’m on a deadline.
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Synthetic Cannabinoids
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A case report of synthetic cannabinoid use disorder
Accelerated HD-tACS for craving and cognition in synthetic cannabinoid use disorder: A case report
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3rd generation synthetic cannabinoid metabolites
NPS metabolomics: Structure elucidation of third generation synthetic cannabinoid metabolites and fentanyl analogue metabolites
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Cool Chemistry & Tools
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On making CBD & CBG conjugates & testing their antioxidative effects
Synthesis of cannabidiol and cannabigerol bixin conjugates and investigation of their antioxidative effect
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On making new CBG derivatives using Mannich-type modifications
Biológiailag aktív kannabigerol származékok el?állítása Mannich típusú reakcióval
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For various analytical methods, an assessment of their environmental impact
Greenness assessment of analytical methods for determination of cannabinoids in oils using NEMI, Analytical Eco-Scale, AGREE and GAPI
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Using HPLC to determine cannabinoid levels in commercial CBD oil
High-Performance Liquid Chromatography for the Determination of Cannabinoids in Commercial CBD Oil
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Thanks.
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PS: For today’s legend of Cuban piano, Rubén González’s album ‘Introducing’. Helping to create the cha-cha style & said to have "forged the style of modern Cuban piano playing in the 1940s", González started the piano at 6 but always thought he’d be a doctor. He finally abandoned medical school because “music was in the blood”. He played with the most influential bands of the ‘40’s & spent the next 40 years touring & playing across Central & South America. But it wasn’t until after his supposed retirement in the ‘90s that he found worldwide fame. First recording with the Afro-Cuban All-Stars & then the phenomenon of the ‘Buena Vista Social Club’ album & film by Wim Winders, he made several more albums before his death, including ‘Introducing’. He recorded this album in two days with no overdubs. As he said, "If I can't take a piano with me to heaven, then I don't want to go."
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