C&P#110: CBD for the brain, the skin & the anxiety
Lex Pelger
'Cannabinoids & the People' newsletter on Substack + canna-edu vids on YT @cannabinoidsandthepeople + the Moby Dick pot books (graphic novels on cannabis)
[As always, for the best formatting, see the edition on Substack:
This week…
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Hello everyone,
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Welcome to the 110th edition of Cannabinoids & the People, Lex Pelger’s free weekly digest of all the new cannabinoid science + assorted canna-news & psychedelic updates. On the cannabinoids, ask me anything.
Editor’s note:
I’m now back full-time after summer vacations but my Google Scholar Alerts are now 700 emails deep, so the next few newsletters will be extra full with new science as I catch up. Enjoy!
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Free resources
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For more… (my Linktree)
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A request to spread the word This newsletter only spreads by word of mouth, so please forward to colleagues & tell your friends & relatives.
My work this week:
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My TikToks: (@lexpelgerandhisbooks or on YouTube)
Ways to support this work:
Venmo: @Lex-Pelger PayPal: donate here
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Best Of Cannabinoid Science...
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Dr. Ben Caplan: “Will a Low Dosage of THC (2.5 mg) with CBD Trigger a Fast Heart Rate?” https://benjamincaplan.com/question/low-dose-thc-and-heart-rate “In the simplest answer, a low dose of THC (like 2.5 mg) combined with CBD is likely to cause only a mild increase in heart rate, if any, and CBD might even help balance it out.”
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For both scientist & sellers, it should be noted that CBD binds to borosilicate glass (9%) & polyethylene plastics (15%) Non-linear plasma protein binding of cannabidiol https://pubmed.ncbi.nlm.nih.gov/38902820/
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Safety tests of 19 commercial CBD oils found concentrations different from the label ranging from 81 to 226% Comprehensive analysis of 19 cannabinoids in commercial CBD oils: concentrations, profiles, and safety implications https://link.springer.com/article/10.1007/s00003-024-01513-9
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An analysis of the evolutionary history of the cannabinoid receptors Exploring the evolutionary trajectory and functional landscape of cannabinoid receptors: A comprehensive bioinformatic analysis https://www.sciencedirect.com/science/article/pii/S1476927124001269
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Clinical
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In older adults, an assessment of medical cannabis use found a decline in all symptoms including negative affect, pain & nausea Effects of medical cannabis use on physical and psychiatric symptoms across the day among older adults https://pubmed.ncbi.nlm.nih.gov/38924900/
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In a case report of neuropathic pain from chemotherapy treatment, CBD & exercise improved pain symptoms, mobility, hand & finger dexterity, upper & lower body strength, beneficial gut bacteria & quality of life Impact of Cannabidiol and Exercise on Clinical Outcomes and Gut Microbiota for Chemotherapy-Induced Peripheral Neuropathy in Cancer Survivors: A Case Report https://www.mdpi.com/1424-8247/17/7/834
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In a double-blind placebo trial of hemp-derived CBD in healthy adults, those taking the CBD had lower pain scores The effects of a brand-specific, hemp-derived cannabidiol product on physiological, biochemical, and psychometric outcomes in healthy adults: a double-blind, randomized clinical trial https://pubmed.ncbi.nlm.nih.gov/38904150/
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In adults with Lennox-Gastaut syndrome (a childhood-onset epilepsy), CBD as an add-on treatment reduced the frequency of both focal & generalized seizures & was well tolerated with 94% of the cohort continuing on the drug Is adjunctive Cannabidiol effective in controlling seizures for adult patients with Lennox-Gastaut Syndrome? - A single centre long term follow up study https://pubmed.ncbi.nlm.nih.gov/38908033/ And in two case reports of difficult-to-treat status epilepticus (seizures that last more than 5 minutes), treatment with CBD via a gastric tube reduced seizures Effectiveness of Highly Purified Cannabidiol in Refractory and Super-Refractory Status Epilepticus: A Case Series https://pubmed.ncbi.nlm.nih.gov/38910424/
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For ADHD, a thesis project interviewing people on the effects of acute & chronic cannabis use CHRONIC AND ACUTE EFFECTS OF CANNABIS ON COGNITION AND SYMPTOMS OF ATTENTION-DEFICIT/HYPERACTIVITY DISORDER https://rex.libraries.wsu.edu/esploro/outputs/doctoral/CHRONIC-AND-ACUTE-EFFECTS-OF-CANNABIS/99901121130101842
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In young adults who regularly use cannabis, acute administration reduced the amount of mitochondrial DNA in their blood for the next hour Acute Cannabis Administration Transiently Reduces Mitochondrial DNA in Young Adults: Findings from a Secondary Analysis of a Double-Blind, Placebo-Controlled, Randomized Clinical Trial https://www.liebertpub.com/doi/pdf/10.1089/can.2023.0282
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A thesis project on cannabis altering the cortisol rhythms in chronic users TRANSLATIONAL EXAMINATION OF CANNABIS-RELATED CHANGES IN DIURNAL STRESS RHYTHMS https://rex.libraries.wsu.edu/esploro/outputs/doctoral/TRANSLATIONAL-EXAMINATION-OF-CANNABIS-RELATED-CHANGES-IN/99901121534801842
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In a trial of muscle fatigue & soreness, a formulation of beta-caryophyllene for 30 days significantly improved muscle fatigue, aerobic function & endurance as well as a significant reduction in pain Effect of a Phytochemical formulation on Muscle fatigue, Energy, Recovery in Delayed Onset Muscle Soreness (DOMS), inflammation and Stress in Healthy Subjects: Results from a Randomized Placebo Controlled Study https://fortuneonline.org/articles/effect-of-a-phytochemical-formulation-on-muscle-fatigue-energy-recovery.pdf
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In horses, CBDA seemed to be more bioavailable in the GI tract than CBD Plasma exposure of cannabidiol and cannabidiolic acid after oral administration to the horse https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jvp.13374
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HCP Corner: for docs, nurses & health workers
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For pharmacists, an excellent guide to potential drug interactions with cannabis Navigating Cannabis: Understanding Its Clinical Significance and Drug Interactions for Pharmacists and Pharmacy Technicians https://pharmtrue.care/wp-content/uploads/2024/06/Navigating-Cannabis_-Understanding-Its-Clinical-Significance-and-Drug-Interactions-for-Pharmacists-and-Pharmacy-Technicians.pdf
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For anesthesiologists, a new tool for providing a framework for a pre-anesthesia cannabis use assessment Enhancing the Preanesthesia Evaluation: Consensus Development of the Cannabis Use and Behaviors Assessment Tool (CUBAT) https://www.sciencedirect.com/science/article/pii/S1089947224001096
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Harms
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A review of harm reduction strategies for cannabis-related problems Harm reduction strategies for cannabis-related problems: a literature review and typology https://link.springer.com/article/10.1007/s00406-024-01839-3
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A review of the potential neurological complications from cannabinoids Neurological Complications of Cannabinoids https://pubmed.ncbi.nlm.nih.gov/38914126/ “Acute cannabinoid exposure can cause neuropsychiatric symptoms in addition to altering cerebral blood flow, leading to cerebrovascular complications such as ischemic stroke, subarachnoid hemorrhage, and reversible cerebral vasoconstriction syndrome (RCVS). Chronic use, particularly among adolescents, may be associated with increased risk of long-term cognitive deficits, schizophrenia, and other neuropsychiatric effects. Synthetic cannabinoids have increased potency, with reports of causing profound neurological complications including coma, seizures, posterior reversible encephalopathy syndrome, and RCVS [Reversible Cerebral Vasoconstriction Syndrome – “thunderclap” headaches].”
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In people with schizophrenia & cannabis use disorder, “a modest single dose of oral THC was associated with worse cognitive functioning [for] several hours… and a THC dose-response effect was seen for negative symptoms” Randomized Laboratory Study of Single-Dose Cannabis, Dronabinol, and Placebo in Patients With Schizophrenia and Cannabis Use Disorder https://pubmed.ncbi.nlm.nih.gov/38900958/ And in adults with cannabis use disorder, those with greater sleep difficulties also had worse memory performance The role of sleep in the link between cannabis use and memory function: evidence from a crosssectional study https://www.tandfonline.com/doi/pdf/10.1080/00952990.2024.2362832
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In European hospitals, an analysis of 500 cases of synthetic cannabinoid visits Clinical effects of cannabis compared to synthetic cannabinoid receptor agonists (SCRAs): a retrospective cohort study of presentations with acute toxicity to European hospitals between 2013 and 2020 https://www.tandfonline.com/doi/pdf/10.1080/15563650.2024.2346125
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In S?o Paulo's open-air drug scene known as Crackland, 20% of the people reported consuming synthetic cannabinoids Two in ten patients seeking addiction treatment within S?o Paulo's Crackland report recent use of Synthetic Cannabinoids https://pubmed.ncbi.nlm.nih.gov/38904450/
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In Russia, a report on the mental health effects of synthetic cannabinoids Deformation of mental disorders in the misuse of synthetic cannabinoids https://new.vestnik-surgery.com/index.php/2415-7805/article/view/9232
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In a rodent model of prenatal vaporized THC exposure, the adolescent offspring had decreased object exploration (especially in females) which is an indicator of attention Vaporized Δ9-tetrahydrocannabinol exposure in utero has negative effects on attention in a dose- and sex-dependent manner https://pubmed.ncbi.nlm.nih.gov/38914267/
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Reviews
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For neurological diseases, a book chapter on the use of cannabinoids Cannabis Compounds: Potential Therapy for Neurological Disease https://www.intechopen.com/online-first/1186209
And for neurodegenerative disorders, on the synergistic therapeutic benefits of CBD with vitamin B12 Cannabinoids: Potential for Modulation and Enhancement When Combined with Vitamin B12 in Case of Neurodegenerative Disorders https://pubmed.ncbi.nlm.nih.gov/38931480/
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For pediatric dentistry with autism spectrum disorder, a review of using CBD THE USE OF CANNABIDIOL IN PEDIATRIC DENTISTRY PATIENTS WITH AUTISM SPECTRUM DISORDER: INTEGRATIVE REVIEW https://www.researchgate.net/publication/381525540_THE_USE_OF_CANNABIDIOL_IN_PEDIATRIC_DENTISTRY_PATIENTS_WITH_AUTISM_SPECTRUM_DISORDER_INTEGRATIVE_REVIEW
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For anxiety, a meta-analysis of eight studies showed CBD to have a considerable effect size Therapeutic potential of cannabidiol (CBD) in anxiety disorders: A systematic review and meta-analysis https://pubmed.ncbi.nlm.nih.gov/38924898/ And a review on whether the serotonin & BDNF-TrkB signaling systems mediate CBD's antidepressant effects New insights into the involvement of serotonin and BDNF-TrkB signalling in cannabidiol’s antidepressant effect https://www.researchgate.net/profile/Samia-Joca/publication/380648715_New_insights_into_the_involvement_of_serotonin_and_BDNF-TrkB_signalling_in_cannabidiol's_antidepressant_effect/links/665ebc09d59c846ad4302155/New-insights-into-the-involvement-of-serotonin-and-BDNF-TrkB-signalling-in-cannabidiols-antidepressant-effect.pdf
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For cancer symptoms, a review of 40 studies on the help from cannabis Medical marijuana in the treatment of cancer-associated symptoms https://pubmed.ncbi.nlm.nih.gov/38899936/ And a review of six studies on the use of cannabinoids for the anorexia caused by cancer treatments The potential of cannabinoids in managing cancer-related anorexia in older adults: a systematic review of the literature https://pubmed.ncbi.nlm.nih.gov/38917597/
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For multiple sclerosis, a review of using the cannabinoids Exploring the efficacy of cannabinoids in the management of multiple sclerosis https://www.researchgate.net/publication/381624416_Exploring_the_efficacy_of_cannabinoids_in_the_management_of_multiple_sclerosis
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A review of CBD metabolism by the liver & the potential of liver toxicity Metabolism and liver toxicity of cannabidiol https://pubmed.ncbi.nlm.nih.gov/38904421/
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Preclinical
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In a skin stem cell model of acne & acne scarring, CBD “remarkably” reduced pro-inflammatory cytokines, increased the levels of elastin & collagens, inhibited lipid synthesis & promoted apoptosis (programmed cellular suicide close parents among damaged cells Potential of cannabidiol as acne and acne scar treatment: novel insights into molecular pathways of pathophysiological factors https://pubmed.ncbi.nlm.nih.gov/38904694/
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In a liver cell study of consumer exposure to cannabinoids, CBD, CBN & hemp extracts at the highest levels did not alter cell viability & had only modest effects on albumin & urea secretion as well as mitochondrial membrane potential Examining the hepatotoxic potential of cannabidiol, cannabidiol-containing hemp extract, and cannabinol at consumer-relevant exposure concentrations in primary human hepatocytes https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jat.4646 And in a model of non-alcoholic fatty liver disease, a thesis project on beta-caryophyllene showed promise as a treatment via the lowered release of extracellular vesicles BETA-CARYOPHYLLENE AS A THERAPEUTIC AGENT IN 2D AND 3D IN VITRO MODELS OF HEPATIC STEATOSIS: POTENTIAL INVOLVEMENT OF EXTRACELLULAR VESICLES https://iris.unito.it/handle/2318/1986690
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In a mouse model of memory loss induced by scopolamine, CBD protected from the memory loss & produced synergistic protection effects when combined with rivastigmine (a cholinesterase inhibitor used to treat mild Alzheimer's disease) The Influence of an Acute Administration of Cannabidiol or Rivastigmine, Alone and in Combination, on Scopolamine-Provoked Memory Impairment in the Passive Avoidance Test in Mice https://pubmed.ncbi.nlm.nih.gov/38931476/ Ugh. Those poor mice. Scopolamine comes from the datura plant & it's classified as a deliriant. When you look up the clinical test of this drug from places like Edgewood in the 1950s, you see how scary it is to take something that causes you to experience intense hallucinations that you perceive to be very real.
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In obese mice, the weight reductions caused by THC can be predicted by the variations it causes in the microbiome Microbiome Variations Induced by delta9-Tetrahydrocannabinol (THC) Predicts Weight Reduction in Obese Mice https://www.frontiersin.org/journals/microbiomes/articles/10.3389/frmbi.2024.1412468/abstract
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In a model of colitis, CBD reduced intestinal damage & cell death Cannabidiol decreases histological intestinal injury in a neonatal experimental model of necrotizing enterocolitis https://link.springer.com/article/10.1186/s42826-024-00211-9
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In a tissue model of atherosclerosis (hardened arteries), CBD modulated cholesterol levels in the macrophages (immune cells) via ceramide levels & ABCA1 & ABCG1 expression controlled by the nuclear PPAR receptors (regulators of genetic expression) Cannabidiol (CBD) Inhibits Foam Cell Formation via Regulating Cholesterol Homeostasis and Lipid Metabolism https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.202400154
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In a rat model of high blood pressure in the lungs, a pharmaceutical CBD drug significantly reduced pulmonary arterial pressure & hypertrophy of the right ventricles as well as reversing pulmonary vascular remodeling via the reduction of pyroptosis (inflammatory cell death) using inhibition of the NF-κB/NLRP3/Caspase-1 pathway DYZY01 alleviates pulmonary hypertension via inhibiting endothelial cell pyroptosis and rescuing endothelial dysfunction https://www.sciencedirect.com/science/article/pii/S0014299924004734
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Another toxicity analysis of CBD found it to be non-mutagenic & non-genotoxic Exploring the safety of cannabidiol (CBD): A comprehensive in vitro evaluation of the genotoxic and mutagenic potential of a CBD isolate and extract from Cannabis sativa L https://pubmed.ncbi.nlm.nih.gov/38908200/ Well, I guess I’ll have to get my mutant powers some other way. Where did I leave my radioactive bookworm?
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In a snail model of different stress conditions (predator scent, food deprivation, acute heat shock, bacterial inflammation), different effects were observed on the endocannabinoid enzymes & their inflammation & anxiety responses Different stressors uniquely affect the expression of endocannabinoid-metabolizing enzymes in the central ring ganglia of Lymnaea stagnalis https://pubmed.ncbi.nlm.nih.gov/38922726/
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A spider toxin that reduces pain via the endocannabinoid system The synthetic peptide, PnPP-15, derived from the PnTx2-6 toxin of the spider Phoneutria nigriventer, induces peripheral antinociception involving neprilysin, opioid, and cannabinoid systems https://www.sciencedirect.com/science/article/pii/S2950200424000120
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In a rat model of radiation causing small intestine inflammation, the traditional Chinese medicine treatment of Kushen Injection reduced inflammation via the CB1 receptor Compound Kushen Injection improves radiation enteritis via cannabinoid receptor 1 in rats https://assets-eu.researchsquare.com/files/rs-4513715/v1/a42486fb-3016-49a4-ad83-a85a603699f0.pdf?c=1719252440 One more for our list of traditional medicines utilizing the endocannabinoid system...
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the Headlines & Fav Articles
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A US Health & Human Services report says federal cannabis prohibition “hinder our ability to fully understand” its therapeutic potential https://www.marijuanamoment.net/marijuana-prohibition-hinders-ability-to-fully-understand-its-effects-top-federal-health-agency-says-in-new-report
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For adolescents, a study from the US Substance Abuse & Mental Health Services Administration finds teen consumption of cannabis dropping in states that legalized https://www.marijuanamoment.net/teen-marijuana-use-is-lower-now-than-before-states-started-legalizing-it-for-adults-federal-report-shows And similar findings from the CDC https://www.marijuanamoment.net/teen-marijuana-use-has-fallen-over-the-past-decade-as-more-states-enacted-legalization-new-cdc-report-shows
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For female orgasmic disorder, more states considering adding it as a qualifying condition for cannabis https://www.marijuanamoment.net/more-states-consider-adding-female-orgasm-disorder-as-a-medical-marijuana-qualifying-condition
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International
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On cannabis use around the world, a review of 39 studies gave an international average of 12% In legal countries & 5% in non-legal countries Prevalence of Cannabis Use around the World: A Systematic Review and Meta-Analysis, 2000-2024 https://pubmed.ncbi.nlm.nih.gov/38933041/ “The prevalence of cannabis use varied between 0.42% and 43.90% across 33 European countries, 1.40% to 38.12% across 15 North and South American countries, 0.30% to 19.10% across 16 Asian countries, and 1.30% to 48.70% across 18 Oceania and African countries.”
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The Laws, The War on Drugs & the End of Prohibition
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In California, a look at the effects of policies such as banning storefront adult-use cannabis businesses as well as specific restrictions on product types, potency, packaging, labeling or server training requirements Associations of Local Cannabis Control Policies With Harmful Cannabis Exposures Reported to the California Poison Control System https://journals.lww.com/epidem/fulltext/2024/07000/associations_of_local_cannabis_control_policies.4.aspx “Localities that ultimately banned storefront recreational retail cannabis businesses had fewer harmful cannabis exposures for children aged <13 years … but not for people aged >13 years … Of 167 localities ultimately permitting recreational cannabis sales, overall restrictiveness was not associated with harmful cannabis exposures among children aged <13 years, but for people aged >13 years, a 1-standard deviation increase in ultimate restrictiveness was associated with fewer harmful cannabis exposures… Bans on storefront retail and other restrictive approaches to regulating recreational cannabis may be associated with fewer harmful cannabis exposures for some age groups following statewide commercialization.”
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In Canada during the years of legalization, medical cannabis use increased from 4% to 11% & recreational cannabis use increased from 9% to 15% Changes in medical cannabis use in Ontario, Canada (2014 to 2019): Trajectory of trends, medical authorization patterns and association with recreational cannabis legalization https://www.sciencedirect.com/science/article/pii/S2211335524002201
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In northern Canadian territories, only modest effects found for cannabis education campaigns Associations between noticing public health education campaigns about cannabis and risk perceptions in the northern Canadian territories: a cross-sectional study https://pubmed.ncbi.nlm.nih.gov/38905013/
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Psychedelics, Plant Medicines & Other Psychoactives
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For South by Southwest psychedelic panels, here’s two you should upvote: Queer Visions of Our Psychedelic Future + Behind the Scenes of the "Psychedelic Renaissance" (which includes Josh Hardman of Psychedelic Alpha, see below)
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领英推荐
The FDA rejected the MDMA-assisted therapy for PTSD application from Lykos & reportedly requested another Phase III study of safety & efficacy https://psychedelicalpha.com/news/breaking-fda-rejects-lykos-therapeutics-mdma-assisted-therapy-for-ptsd (Psychedelic Alpha is absolutely one of the top resources for news & analysis in the psychedelic space) And here’s Lucid News on the response from Lykos https://www.lucid.news/maps-responds-to-fda-advisors-and-sets-future-goals/ And a report on how 3 of Lykos’ MDMA papers are being retracted https://www.psychedelicweek.com/p/mdma-maps-lykos-doblin-retract-trial-fda-ptsd
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The Psychoactive Research
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A survey of experts on how MDMA therapy might be implemented in Europe Expert opinions on implementation of MDMA-assisted therapy in Europe: critical appraisal towards training, clinical practice, and regulation https://pubmed.ncbi.nlm.nih.gov/39113624/
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How false insights & beliefs can originate under psychedelic influence An Integrated theory of false insights and beliefs under psychedelics https://www.nature.com/articles/s44271-024-00120-6
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A survey of people with psychotic experiences & their thoughts on their use of psychedelics Experiences of psychedelic drug use among people with psychotic symptoms and disorders: Personal growth and mystical experiences https://akjournals.com/view/journals/2054/aop/article-10.1556-2054.2024.00348/article-10.1556-2054.2024.00348.xml “Most respondents (n = 88) stated that their psychedelic experience resulted in some degree of personal growth. Many also described mystical-type experiences, increased levels of contemplation and spirituality, improved insight, symptomatic improvements, and feelings of love and appreciation following the experience. Most described overall positive experiences, however, 11% (n = 11) described overall negative experiences, which included symptom exacerbation, dysphoria, and terror, and a slightly larger portion described mixed-type experiences.”
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For HIV-related shame, a clinical trial of using psilocybin-assisted therapy Psilocybin-assisted therapy and HIV-related shame https://pubmed.ncbi.nlm.nih.gov/39095420/
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For developmental stuttering, on the potential of using psychedelics Psychedelics in developmental stuttering to modulate brain functioning: a new therapeutic perspective? https://pubmed.ncbi.nlm.nih.gov/38962146/
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A survey on the musical preferences of people using psychedelics Preferences and Attitudes Toward Music in Nonclinical Uses of Psychedelics https://www.liebertpub.com/doi/abs/10.1089/psymed.2024.0003
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The Plant & the History
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Growing, Farming & Processing
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On the perspective of Black farmers on social equity in the hemp industry Black Farmers' Perspectives on Social Equity Within the United States Hemp Industry https://digitalscholarship.tnstate.edu/dissertations/AAI31140901/ “Twenty current and former Black hemp farmers from Tennessee, Georgia, South Carolina, and Missouri participated in semi-structured interviews, which produced the following emerging themes: a lack of education provided to Black hemp farmers; a lack of financial resources; and policy implementation irregularities.”
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Triploid cannabis plants (3 copies of their genome) far less likely to be fertilized by pollen Characterization of agronomic performance and sterility in triploid and diploid cannabinoid hemp https://acsess.onlinelibrary.wiley.com/doi/pdf/10.1002/agj2.21618 “Though not completely pollen-insensitive, triploidy is an effective means to reduce seed production and improve yields and quality in cannabinoid hemp in the presence of pollen.”
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On the best methods for drying cannabis without altering total THC THC Content on a Dry Weight Basis: Implications for Hemp Legality https://academic.oup.com/jaoac/advance-article-abstract/doi/10.1093/jaoacint/qsae048/7698044?redirectedFrom=fulltext
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In Romania, an analysis of the many bugs living around hemp plants RESEARCH ON THE ENTOMOFAUNA STRUCTURE FROM THE MONOECIOUS HEMP CROP, CULTIVATED IN AN ECOLOGICAL SYSTEM AT A.R.D.S. SECUIENI https://www.researchgate.net/publication/381887824_RESEARCH_ON_THE_ENTOMOFAUNA_STRUCTURE_FROM_THE_MONOECIOUS_HEMP_CROP_CULTIVATED_IN_AN_ECOLOGICAL_SYSTEM_AT_ARDS_SECUIENI “423 specimens were collected, belonging to 4 orders, 11 families, 12 subfamilies, 13 genera and 15 species. The order Coleoptera [beetles] had the maximum weight by the number of specimens collected (48.70%), while the order Lepidoptera [butterflies & moths] recorded a weight of only 0.24%. The Gryllidae [crickets] family had the maximum weight by the number of specimens collected (36.88%), while the Noctuidae [owlet moths] and Scutelleridae [jewel bugs] families have 0.24% each.”
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In the Czech Republic, two species of powdery mildew The co-occurrence of two powdery mildew species on Cannabis sativa in the Czech Republic https://onlinelibrary.wiley.com/doi/pdf/10.1111/jph.13348
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A thesis project analyzing the impact of cannabis cultivation in Humboldt Impacts of Cannabis Cultivation in Humboldt County https://digitalcommons.humboldt.edu/cgi/viewcontent.cgi?article=1024&context=chanterelle
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Identifying varieties using AI & spectral signatures Hyperspectral reflectance for classification of medicinal Cannabis varieties using machine learning algorithms https://www.spiedigitallibrary.org/journals/optical-engineering/volume-63/issue-6/064103/Hyperspectral-reflectance-for-classification-of-medicinal-Cannabis-varieties-using-machine/10.1117/1.OE.63.6.064103.short#_=_
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On using liquid-liquid chromatography to separate cannabinoids from hemp extracts Modeling the liquid-liquid chromatography separation of cannabinoids from hemp extracts https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jssc.202400239
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Food & Nutrition
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For hemp seeds, a comparison of the various extraction methods Comparison of physicochemical characteristics, functional properties and biological activities of hemp seed proteins by different extraction methods https://he.tinsun.hk/assets/HE-20240001.pdf
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In olives, fermentation & alkalization increased the formation of endocannabinoid-like compounds Effects of fermentation and alkalisation on the formation of endocannabinoid-like compounds in olives https://pubmed.ncbi.nlm.nih.gov/38909454/ “While N-oleoylethanolamide, N-palmitoylethanolamide, N-linoleoylethanolamide, 1- and 2-oleoylglycerol, 1- and 2-linoleoylglycerol, and oleoylphenylalanine were initially absent or present in trace amounts, their levels significantly rose during fermentation. The formation rate of these compounds was higher in olives fermented in water than those in brine.” Olives are already known to be neuroprotective, partially via their effects on the FAAH enzyme (which breaks down anandamide).
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For broiler chickens, consumers had a positive impact about them when they learned they were fed CBD extracted from hemp The Role of Consumer Knowledge in Purchase Intention of Broiler Feed with Hemp through Trust : A Multi-group Analysis of Gender https://so04.tci-thaijo.org/index.php/journalmbsmut/article/view/273388
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In pigs, a thesis project on using hemp seed meal as an alternative protein source HEMP SEED MEAL AS AN ALTERNATIVE PROTEIN SOURCE IN GROWING PIGS DIET: A PILOT STUDY https://ecommons.cornell.edu/server/api/core/bitstreams/6695f72e-3c57-4c73-9382-f8cb2bcc14fd/content
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Industrial Use
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On creating aerogels from hemp stems Multifunctional aerogels with thermal insulation, elasticity, and hydrophobicity derived from hemp stems https://www.sciencedirect.com/science/article/abs/pii/S0926669024009099
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For the processing of hemp hurds into biogas, an analysis of pretreatment methods (acid, alkali & thermal) Effect of various thermochemical pretreatment methods on the biomethanisation of hemp (Cannabis sativa) hurd and kinetic analysis https://rhodes2024.uest.gr/files/proceedings/XIII/284.Rhodes24_18.45-19.00.pdf
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On using hemp to clean lead from the soil & to produce bioenergy Utilization of hemp (Cannabis sativa L.) in a circular economy model: investigating the use of hemp for phytoremediation of Pb-contaminated soils and bioenergy production https://rhodes2024.uest.gr/files/proceedings/XIV/222.Rhodes24_19.15-19.30.pdf
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On creating silver nanoparticles from cannabis Green Synthesis of Silver Nanoparticles from Cannabis sativa: Properties, Synthesis, Mechanistic Aspects, and Applications https://www.mdpi.com/2305-7084/8/4/64 Silver nanoparticles have therapeutic applications that include cancer treatment, skin burns & antiviral activity. “Silver nanoparticles, in particular, have garnered significant attention due to their exceptional effectiveness, biocompatibility, and eco-friendliness. Cannabis (Cannabis sativa L.) has emerged as a promising candidate for aiding in the green synthesis of silver nanoparticles.”
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On using hemp to make anodes for sodium-ion batteries Supplementary data for Enhancing waste hemp hurd-derived anodes for sodium-ion batteries through hydrochloric acid-mediated hydrothermal pretreatment https://digital.csic.es/handle/10261/361155
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Analysis of the strength of hemp & e-glass composites EXPERIMENTAL INVESTIGATION ON FLEXURAL STRENGTH AND FRACTURE TOUGHNESS OF HYBRID HEMP AND E-GLASS COMPOSITES https://www.researchgate.net/profile/Ravi-Y-V-2/publication/381552816_Section_A-Research_paper_Experimental_Investigation_on_Flexural_strength_and_Fracture_Toughness_of_Hybrid_Hemp_and_E-Glass_Composites_EXPERIMENTAL_INVESTIGATION_ON_FLEXURAL_STRENGTH_AND_FRACTURE_TOUGH/links/6673fdf91dec0c3c6f940ee6/Section-A-Research-paper-Experimental-Investigation-on-Flexural-strength-and-Fracture-Toughness-of-Hybrid-Hemp-and-E-Glass-Composites-EXPERIMENTAL-INVESTIGATION-ON-FLEXURAL-STRENGTH-AND-FRACTURE-TOUGH.pdf
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On creating an emulsion based on hemp seed oil stabilized by soap nuts Characterization of hemp seed oil emulsion stabilized by soap nuts (Sapindus mukorossi) extract https://www.sciencedirect.com/science/article/abs/pii/S0268005X2400626X
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CANNABINOID SCIENCE
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A NIST (National Institute of Standards and Technology) paper on how to analyze cannabis samples Characterization of Reference Material 8210: Hemp Plant https://www.nist.gov/publications/characterization-reference-material-8210-hemp-plant
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Public Health
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In an analysis of the operational model of cannabis use in Thai public hospitals, cannabis was being used the most for insomnia, cancer, muscular tendon diseases, neuropathic pain & psoriasis as well as combined with Thai traditional medicine The Operation Model Development for Medical Cannabis Using of Public Hospitals in Sukhothai Province, Thailand https://so05.tci-thaijo.org/index.php/cmruresearch/article/view/268272
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A social science analysis of Reddit cannabis posts The Reddit cannabis subjective highness rating scale: Applying computational social science to explore psychological and environmental correlates of naturalistic cannabis use https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0300290 “Posters reported greater subjective highness when using language that referred to in-person social environments and lower subjective highness when using language that referred to online social environments and positive affect psychological states.”
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Adolescents & Young Adults
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In young adults, risk factors for vaping cannabis & nicotine Cannabis and vaping nicotine: An exploration of risk factors using a nationally representative sample of youth and young adults https://pubmed.ncbi.nlm.nih.gov/38936264/
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In young adults, a behavioral economic demand study on the co-use of cannabis & alcohol Prospective associations of behavioral economic demand for cannabis and alcohol with simultaneous cannabis and alcohol use among young adults https://pubmed.ncbi.nlm.nih.gov/38900508/
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The Brain & Neurological Disorders
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In Alzheimer's disease, the alterations to the endocannabinoid system with gendered effects Alteration of the Endocannabinoid System in Human Alzheimer’s Disease Brain https://usurj.journals.usask.ca/article/view/659 “Our research demonstrated that the EC is indeed altered in AD brains, with CB1R expression increasing in the hippocampus. Furthermore, we found a sex-dependent difference in the EC alteration, with females having a greater expression of CB1R in the hippocampus compared to males. Finally, a strong correlation was observed between CB1R expression and FAAH expression in the cortex, hippocampus, and cerebellum of males, but no such correlation existed in the female data… Our data suggests that CB1R expression is regulated by FAAH activity in males but not females.”
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In a rat model of stress, a thesis project on how the endocannabinoids regulate the lateral habenula (a brain region relating to the stress response & cognitive performance LATERAL HABENULA AND ENDOCANNABINOID REGULATION OF STRESS-RELATED BEHAVIOR https://rex.libraries.wsu.edu/esploro/outputs/doctoral/LATERAL-HABENULA-AND-ENDOCANNABINOID--REGULATION/99901120940901842
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Mental Health & Substance Use Disorders
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In men with cannabis use disorder, their comparative coping styles depended on their level of addiction Healthy coping styles in men with cannabis use disorder: comparative study of mild, moderate, and severe level https://www.tandfonline.com/doi/abs/10.1080/14659891.2024.2372094
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A small review of cannabis for mental health Exploring the Significance of Pharmaceutical Care in Mental Health: A Spotlight on Cannabis https://www.mdpi.com/2226-4787/12/4/100
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Pain & Inflammation
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For chronic prostatitis or pelvic pain, an enema of PEA, calendula & epilobium (willowherbs) improved several measurements Efficacy of palmitoylethanolamide, epilobium and calendula suppositories for the treatment of patients with chronic prostatitis/chronic pelvic pain syndrome type III https://www.pagepressjournals.org/aiua/article/view/12582
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In people with opioid use disorder using methadone, THC altered their attention towards opioid cues A preliminary investigation of the acute effects of delta-9-tetrahydrocannabinol on pain and opioid attentional bias among persons with opioid use disorder https://www.sciencedirect.com/science/article/abs/pii/S0022395624003765
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In a mouse model of pain being treated with morphine, a negative allosteric modulator of the CB1 receptor (also a function of CBD) synergized to increase pain relief while suppressing morphine tolerance & withdrawal Negative allosteric modulation of CB1 cannabinoid receptor signaling suppresses opioid-mediated tolerance and withdrawal without blocking opioid antinociception https://www.sciencedirect.com/science/article/abs/pii/S0028390824002211
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In a mouse model of neuropathic pain, a drug that inhibited FAAH & MAGL (which break down anandamide & 2-AG respectively) led to increased endocannabinoid levels & the impairment of stress-induced pain Disrupted stress-induced analgesia in a neuropathic pain state is rescued by the endocannabinoid degradation inhibitor JZL195 https://pubmed.ncbi.nlm.nih.gov/38922705/
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The antioxidant properties of cannabis leaves Feature-Based Molecular Network-Assisted Cannabinoid and Flavonoid Profiling of Cannabis sativa Leaves and Their Antioxidant Properties https://pubmed.ncbi.nlm.nih.gov/38929189/
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Reproduction & Hormones
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In pregnant people who use cannabis, many were willing to be in a research study A feasibility study to assess the recruitment and retention of pregnant patients who regularly use cannabis https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-024-06826-4
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The Skin
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Assessing a hemp oil emulsfier for topical used as an anti-inflammatory, painkiller & wound healer Formulation and Physicochemical Characterization of Terpenocannabinoid-Functionalized Hemp Oil Emulsifier: Assessment of Topical Anti-Inflammatory, Antinociceptive, Wound Healing Activity and Cutaneous Toxicity Effects https://www.mdpi.com/2218-0532/92/3/36
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The Eyes
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In animal models of the eye, an oral drug that activates the CB2 receptor reduced retinal permeability, white blood cell adhesion in eyes with uveitis (inflammation) or diabetic retinopathy & reduced lesion areas in rats with laser-induced neovascularization (new blood vessel formation reducing vision) RG7774 (Vicasinabin), an orally bioavailable cannabinoid receptor 2 (CB2R) agonist, decreases retinal vascular permeability, leukocyte adhesion, and ocular inflammation in animal models https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1426446/full
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Developing novel cannabinoids for treating dry eye disease & chronic ocular pain Development and screening of a novel library of synthetic endocannabinoid agonists and inhibitors to advance a potential therapy to treat dry eye disease and chronic ocular pain https://iovs.arvojournals.org/article.aspx?articleid=2799176
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Cancer & Chemotherapy
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In uveal melanoma (a rare cancer in the pigment of the eye), a multi-pronged analysis of the endocannabinoid system in cancer cells & patients showed that a drug which activates both CB1 & CB2 receptors (HU-210 ) reduced the cancer cell’s inflammatory factor secretion, viability & proliferation as well as inducing apoptosis (programmed cellular suicide) Targeting Uveal Melanoma with a Potent Cannabinoid:Insights from Cells, Orthotopic Patient-Derived Xenograft, and Patient Biopsies https://iovs.arvojournals.org/article.aspx?articleid=2797511
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In a mouse model of chemotherapy-induced neuropathic pain, hemp essential oil reduced inflammatory cytokines & pain as well as significantly inhibiting tumor growth Chemical compounds, anti-tumor and anti-neuropathic pain effect of hemp essential oil in vivo https://pubmed.ncbi.nlm.nih.gov/38914272/
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Synthetic Cannabinoids
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Cancer therapy via gold nanoparticles loaded with CBD Gold Nanoparticles Loaded with Cannabinoids for Targeted Cancer Therapy https://proceedings.cmbes.ca/index.php/proceedings/article/view/1082
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In mouse neuronal cells, the synthetic cannabinoid CP-55,940 (which activates both the CB1 & CB2 receptor) increased autophagy (cellular recycling) & cholesterol synthesis via the activation of SREBP-2 Incomplete autophagy and increased cholesterol synthesis during neuronal cell death caused by a synthetic cannabinoid, CP-55,940 https://www.sciencedirect.com/science/article/abs/pii/S0161813X24000688
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A new method for detecting synthetic cannabinoid receptor agonists Chromatographic enantioresolution and stereochemical characterization of synthetic cannabinoid receptor agonists with Whelk-O?1 chiral stationary phases under mass spectrometry compatible reversed-phase conditions: A study case with seized samples https://www.sciencedirect.com/science/article/abs/pii/S0003267024007025
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Cool Chemistry & Tools
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A patent on new inhibitors of the MGL enzyme (which breaks down 2AG) for treating diseases Novel Heterocyclic Compounds as Monoacylglycerol Lipase Inhibitors for Treating Multiple Diseases https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.4c00261
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For the CB1 receptor, a comparison of two techniques on predicting binding affinities A head-to-head comparison of MM/PBSA and MM/GBSA in predicting binding affinities for the CB1 cannabinoid ligands https://assets-eu.researchsquare.com/files/rs-4539129/v1/a69fb14f-0fe6-4119-b33a-89ce0a21f488.pdf?c=1719292659
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Thanks. ?- lex
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PS: For today’s space-age percussion album of 1957, Enoch Light & the Light Brigade’s ‘I Want to Be Happy Cha Cha’. A bandleader starting in the 1920s & popular on the hotel circuit of NYC, Enoch Light was one of the first musician/producers to create high-quality recordings that took advantage of the new high-end audio equipment of the late 1950s. He bounced sounds back & forth between the stereo channels, arranged the musicians to change the listening experience & included a long written description of the audio of each track, necessitating the doubling of the album sleeve & pioneering of the “gatefold” packaging format. His music never received much airplay because the AM transmitters of the day had no stereo capabilities but his bright minimalistic albums sold well with 2 of his 25 albums (produced over the span of only 12 years) reaching #1 on the Billboard charts. And in the legacy that we probably all want, in his birthplace of northeastern Ohio, musical events continue to be put on in his honor around his birthday.
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This newsletter is the backbone of my work & I hope it brings you a measure of value. If so, please consider upgrading to a paid subscription & support my sharing all of the new cannabinoid science each week.
President at Medical Resource Association, Inc.
6 个月Thank you ?? for supporting & participating in our upcoming medical cannabis conference! RSVP here: https://mrasrq.com/bordeaux-octobre2024/