COVID and Pulmonary Thrombosis
We suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may induce intravascular pulmonary thrombosis, which may result in the rapid worsening of clinical conditions and, eventually, exitus. Previously published papers have demonstrated that increased levels of D-dimer at hospital admission correlate with a more severe disease (0.5 mg/L) or occurrence of death (1 mg/L). The potential prothrombotic action of the SARS-CoV-2 is supported by the topographical involvement of the lung regions with a predilection for the lower lobe with peripheral involvement. If this hypothesis is demonstrated, this could suggest the benefit of using antithrombotic/coagulation regimens for SARS-CoV-2 and, at the same time, the urgency to identify drugs that could alter the inflammatory storm, thus protecting the vessel wall.
Product Manager Connect&Control Solutions chez VAREX Imaging
4 年https://pubs.rsna.org/doi/10.1148/radiol.2020201544 "Acute Pulmonary Embolism Associated with COVID-19 Pneumonia Detected by Pulmonary CT Angiography" From the Department of Radiology, Centre Hospitalier Universitaire de Besancon, France CT Protocol Our routine protocol for patients with severe clinical features of COVID-19 infection was multidetector pulmonary CT angiography using 256 slice multi-detector CT (Revolution, GE Healthcare, Milwaukee, WI) after intravenous injection of 60 ml iodinated contrast agent (Iomeprol 400 Mg I/mL, Bracco Imaging, Milan, IT) at a flow rate of 4 mL/s, triggered on the main pulmonary artery.