Comprehensive analysis of RNA–chromatin, RNA–, and DNA–protein interactions
NAR Nucleic Acids Research
![NAR Nucleic Acids Research]()
NAR Nucleic Acids Research
Published by Oxford University Press - Impact Factor 16.7
by Daniil?A Khlebnikov, Arina?I Nikolskaya, Anastasia?A Zharikova, and Andrey?A Mironov
RNA-chromatin interactome data is known to be very noisy due to non-specific interactions and protocol issues. To find meaningful regulatory interactions between RNA and DNA, extensive filtering is needed. Researchers propose a new method involving triad interactions among RNA, protein, and DNA, which reduces noise and yields more significant results compared to traditional pairwise interactions. This method can validate RNA-chromatin contacts using specific experiments and filters interactions based on protein functions.