CJC-1295 and Ipamorelin: Your Key to Turn Back the Clock on Aging?

We’re having a revolution in medicine and biology. We’re at the point where the medical community is starting to redefine aging. 

We used to think about growing older almost like an inevitable disease. Our approach to aging healthily was to study the complications and declines in health that come with increasing years around the sun, and then try to find treatments for those, or minimize the risk factors. That strategy is reactive and passive.

But functional and integrative physicians have sought more—and we’re finding it. 

Pioneering scientists and medical researchers are leading a shift in the understanding of aging from one focused on treating disease to one that focuses on preserving health and enhancing the body’s own capacity to heal. 

 We are learning to use principles of preventive medicine to stay healthy and well.

The body has a drive towards balance, especially at the cellular level. Harnessing what we know about cell functions allows us to prevent their breakdown, regardless of the number of candles on our birthday cake. 

That effectively means this: we can keep ourselves young.

Peptide therapy is one way that we’re starting to do that. Some forward-looking physicians and medical practitioners are now using peptides as a way to reverse the cellular clock in your body and enable it to function like it used to when you were younger. 

One of the exciting peptides in this field is CJC-1295.

What is CJC-1295?

CJC-1295 is the creative (or not!) name that scientists have assigned to a particular synthetic peptide.

“Synthetic peptide” just means that it’s a chain of amino acids (the building blocks of proteins) that was created by scientists. It was made to chemically resemble a hormone that your body already makes called growth hormone-releasing hormone (GHRH). GHRH is part of your body’s system to regulate the production and release of growth hormone (GH).

Why growth hormone matters

Growth hormone is essential. It’s involved in a ton of important bodily processes, especially those that support the creation and repair of tissue. For example, it’s involved in muscle gains after a workout, rejuvenating skin cells, repairing injured tissues, improving immune system functioning, and much more. 

Basically, when new cells are being created, growth hormone is part of that process. 

Most people produce lots of growth hormone when they’re young—it’s an important part of children’s development into adulthood. And production of growth hormone continues to be high going into young adulthood. 

Growth hormone declines with age

But—surprise—it starts to decline with age. Growth hormone levels in the blood are much lower in older adults than they are in young adults. That’s part of the reason that your body takes longer to recover as you get older: it doesn’t have the hormonal support it needs to repair and heal itself. 

Increasing growth hormone can be a powerful part of an anti-aging therapy strategy. 

But how can you increase GH levels? 

While it’s possible to supplement growth hormone directly, it’s not ideal. Directly supplementing GH can lead to some nasty side effects. 

Instead, it’s just as effective—and easier on the body—to supplement the other chemicals that regulate growth hormone.

Growth hormone secretagogues

That’s where “growth hormone secretagogues” come in. Growth hormone secretagogues make up a group of peptides that stimulate the production and secretion of growth hormone. 

That means that they stimulate the body to produce and secrete its own growth hormone. That turns out to be a lot easier on your body.

What does CJC-1295 do?

CJC-1295 is one of those growth hormone secretagogues. 

What it does is mimic your body’s naturally made growth hormone-releasing hormone. By doing that, CJC-1295 is able to bind to the same receptors that GHRH does. And so it has the same effect: it tells your body to produce more growth hormone.

What is Ipamorelin?

Ipamorelin is another growth hormone secretagogue. The end result of Ipamorelin is the same as CJC-1295: it increases the GH that’s available in your blood and that makes it to cells. 

But Ipamorelin works slightly differently from CJC-1295.

The chemistry is slightly complicated, but very briefly, Ipamorelin falls into a different category called growth hormone-releasing peptides (GHRPs). GHRPs mimic a substance your body makes called Ghrelin, which is also involved in the regulation of growth hormone. 

Ghrelin helps turn down something called somatostatin—an inhibitor of GH. So Ghrelin basically creates the right conditions for growth hormone to be secreted.

What does Ipamorelin do?

Ipamorelin mimics Ghrelin. Because it looks the same to your body as Ghrelin, it has the same effect of turning down somatostatin and encouraging your body to secrete more GH.

CJC-1295 and Ipamorelin have complementary effects

GHRHs, like CJC-1295, and GHRPs, like Ipamorelin, work together. 

CJC-1295 tells your body to produce more GH. Then, Ipamorelin creates an environment where GH can easily be secreted. 

Together, CJC-1295 and Ipamorelin pack a one-two punch for upping your GH levels and supporting your body to create new tissue.

What are the potential benefits of Ipamorelin and CJC-1295?

Great, so CJC-1295 and Ipamorelin can work together to increase the amount of growth hormone in your blood. We know that they both really do increase GH, and this helps your cells get what they need to function properly, repair themselves, and create new, healthy cells. 

But what does that actually mean for you?

What are the potential health benefits that you would actually notice?

First, I should make it clear that the research is still being done. We don’t yet thoroughly understand all of the effects of either Ipamorelin or CJC-1295. The results look promising, but we still need to do more to gain a comprehensive understanding. 

Still, based on the existing research, there are several potential benefits to your health that you’ll be able to notice.

Faster muscle growth

Faster muscle growth is possible with CJC-1295 and Ipamorelin

Higher levels of growth hormone in the blood make it easier for your body to synthesize proteins and muscle fibers. That means CJC-1295 and Ipamorelin support muscle building: they make it easier for you to gain muscle mass.

Indeed, several studies have found that higher GH levels in the blood lead to significant muscle gains and greater strength. That’s part of the reason that CJC-1295 and Ipamorelin are so popular in bodybuilding communities. 

Fat burning

Another benefit of the higher GH levels that come from growth hormone secretagogues is that they tend to spur on higher metabolism. The bigger the metabolism “fire,” the more fat gets burned. 

Of course, neither CJC-1295 nor any other peptide is a magic weight-loss solution. It takes some effort to lose weight: you have to exercise, eat a reasonably healthy diet, and more. But helping your cells get what they need to actually burn the fat can certainly help.

Younger-looking skin

You already know that age takes a toll on the skin. What’s happening is that the collagen in the skin is breaking down, and is not being replaced. That makes the skin less elastic and thinner. And that leads to wrinkles. 

The formation and maintenance of collagen rely on growth hormone. And it turns out that increasing the amount of growth hormone that’s available in the blood makes it easier for the body to replace collagen. The result is younger-looking skin.

Improved sleep

Quality sleep affects many aspects of your life.

Sleep and growth hormone are linked. 

Much of your body’s growth hormone is secreted while you sleep. That makes sense since sleep is when your body does the most repair of tissue. If you think your muscles grow in the gym, you’re wrong: the gym may initiate the growth, but that growth happens when you sleep.

But it turns out that it goes the other way, too: CJC-1295 appears to improve sleep as well. And better sleep means better health and general bodily functioning.

Are there side effects of CJC-1295?

Again, it’s important to stress that we’re still in the early days of understanding exactly what effects peptides can have on the body. In general, they appear to be safe—partly because rather than adding new substances or chemicals, our bodies already use peptides to communicate. So they’re typically well-tolerated. 

The studies that do exist on CJC-1295 suggest that it’s generally safe, well-tolerated, and has minimal side effects.

Still, some side effects have been noted. These include:

• dizziness
• headache
• nausea
• flu-like symptoms
• hives
• increased heart rate
• flushing
• hyperactivity
• redness and tenderness at injection site
• difficulty swallowing

Possible adverse effects are the reason that all peptide therapies should be conducted under the supervision of a qualified physician. A doctor that specializes in lifestyle medicine can help you ensure that any peptide doses are safe, appropriate for your particular biochemistry, and help you minimize unintended side effects.

Unlock your potential by adding peptides to your health regime.

Peptide Therapy can be powerful

As far as we’ve come in modern medicine, we’ve still got a long way to go. 

The medical community is really just now beginning to see the vast potential of peptide therapies in preserving health and regular functioning as we get older. 

But the promise is there.

CJC-1295 is just one of a number of peptides that—under the proper medical guidance—could be a useful addition to your personalized medicine and health regime.

Schedule a consultation at the Gapin Institute to learn how peptides can help YOU.

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In Male 2.0?, Dr. Tracy Gapin has turned everything we once thought we knew about men’s health and performance upside down. The old model of how to be “a man” is broken. A man who works himself to death. Unfortunately, a man who tries to NOT get sick but isn’t really healthy either. And a man who takes a pill for every ill but is never really cured. That was Male 1.0. Now, imagine being THE MAN ─ owning your performance in the bedroom, the weight room, and the boardroom. Living a fully optimized life. Becoming limitless. This is Male 2.0!

Tracy Gapin, MD, FACS is a board-certified Urologist, world renowned Men’s Health & Performance Expert, Author, and Professional Speaker. Using state-of-the-art biometric monitoring, nutrition and lifestyle intervention, Dr. Gapin coaches Fortune 500 executives and evolutionary leaders of business, sports medicine, and high performance. He specializes in cutting-edge precision medicine with an emphasis on epigenetics, providing men with a personalized path to optimizing health & performance. www.GapinInstitute.com

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References

Bartke, A. (2019). Growth hormone and aging: updated review. The World Journal of Men’s Health, 37(1), 19-30.

Florini, J. R. (1987). Hormonal control of muscle growth. Muscle & Nerve: Official Journal of the American Association of Electrodiagnostic Medicine, 10(7), 577-598.

Raun, K, Hansen, B., Johansen, N., Thogersen, H, Madsen, K, Ankersen, M, & Andersen, P. (1998). Ipamorelin, the first selective growth hormone secretagogue. European Journal of Endocrinology. 139 (5): 552–561.

Seeds, W. (2020). Peptide protocols, volume 1. Seeds scientific performance research.

Teichman, S. L., Neale, A., Lawrence, B., Gagnon, C., Castaigne, J. P., & Frohman, L. A. (2006). Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. The Journal of Clinical Endocrinology & Metabolism, 91(3), 799-805.