The ChEM-H Quarterly, Summer 2024
Credit: Fontejon Photography

The ChEM-H Quarterly, Summer 2024

CBI students' research, faculty Q&As, awards, and more.

FUTURE LEADERS IN CHEMICAL BIOLOGY

To transform research, we have to train a new type of interdisciplinary scientist. The Sarafan ChEM-H Chemistry/Biology Interface (CBI) Training Program prepares a diverse new generation of scientists to integrate chemistry, biology, engineering, and clinical sciences with an aim to revolutionize the future of human health research.

Key findings about a major celiac enzyme

CBI student Agnele Sewa , Chaitan Khosla, SLAC researchers and team made new findings about TG2, a key enzyme behind celiac disease. This could aid the development of first-ever drugs for the autoimmune disorder.

New AI approach optimizes antibody drugs

Developed by CBI students Varun Shanker & Theodora Bruun , along with Peter Kim and Brian Hie , the new method more quickly and accurately predicts the molecular changes that will lead to better antibody drugs.


THE MOLECULES OF HEALTH

The scientists at Sarafan ChEM-H are working to improve human health by uncovering the molecular mechanisms that underlie our biology, and learning where those mechanisms go wrong in disease.

Structure of the PTER enzyme, the protein responsible for breaking down N-acetyltaurin
Structure of the PTER enzyme, the protein responsible for breaking down N-acetyltaurin

Metabolic pathway tied to diet and body weight

A new study led by Wei Wei, Jonathan Z. Long and team reveals that N-acetyltaurine, a byproduct of taurine and acetate, plays an active role in body weight regulation and could lead to improved obesity treatments.

Neutralizing the neutrophil

Neutrophils, a type of immune cell, can attack pathogens by self-destructing, exploding in a process called NETosis. Hawa Racine Thiam is studying NETosis to reduce its damaging effects while retaining its ability to kill real threats.

Glial cells make neurons excitable

Building from a ChEM-H postdoc seed grant, research by Husniye Kantarci , Justin DuBois,?Brad Zuchero, and team reveals that neurons need signals from glia, known as Schwann cells, to become electrically excitable, which could lead to new treatments for chronic pain and epilepsy.


LEARN FROM THE EXPERTS

Hear from two of our Institute Scholars—Jonathan Long and Stanley Qi—on the research that gets them most excited: the science of exercise, and the current state of gene editing.


Decorative image
Credit: Farrin Abbott

The future of exercise

Russ Altman interviews Jonathan Z. Long about his work uncovering the molecules produced during exercise, and what that means for the future of understanding weight loss and anti-diabetes treatments.

CRISPR, gene editing and beyond

Bioengineer Lei (Stanley) Qi on the evolution of CRISPR and how it’s “becoming a discipline, a driving force, and a promise that solves long-standing challenges.”


HONORS AND AWARDS


L-R: David Studdert, Elizabeth Ponder, Carolyn Bertozzi, and Chaitan Khosla

Ponder receives Marsh O’Neill Award for outstanding contributions

Elizabeth Ponder , PhD, Executive Director of Sarafan ChEM-H and the Stanford Innovative Medicines Accelerator (IMA), was recently honored for her exceptional support of Stanford’s scientific research initiatives, strong leadership, and commitment to advancing diversity.

Recent honors

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Sarafan ChEM-H brings together chemists, engineers, biologists, and clinicians to understand life at a molecular level and apply that knowledge to improving human health.



Lasmitha Yogarasa

Teaching Assistant, Department of Natural Science, Open University

3 个月

I'm eagerly waiting to join your team because I admire your research areas.

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