Check out our new preprint SIRT6 as a key initiating point in the loss of proteostasis in aging brains and neurodegeneration.

During aging, and particularly in several neurodegenerative diseases, brain proteostasis is affected. In familial cases, mutated proteins form aggregates. However, this is not the case in age-related neurodegeneration, which encompasses over 90% of cases. Here, where proteins are not mutated, the formation of aggregates requires a molecular explanation.

Our findings resolve a long-standing question of causality in age-dependent neurodegeneration as we determine how the loss of the longevity regulator SIRT6 triggers chromatin changes that lead to proteostasis loss and protein aggregation, ultimately resulting in neurotoxicity .https://www.researchsquare.com/article/rs-4215918/v1

Thanks to our amazing Collaborators, Bjoern Schumacher and Anat Ben Zvi groups!