Celiac Disease: Understanding Gluten Intolerance?

Celiac Disease is a chronic autoimmune condition affecting about 1 in 100 people globally, yet only 30% are properly diagnosed. It occurs in genetically predisposed individuals and is triggered by consuming gluten—a protein in wheat, barley, and rye. Gluten exposure causes the immune system to attack the small intestine's villi, impairing nutrient absorption and leading to various health complications.?

Common Symptoms

Symptoms vary widely, with some experiencing digestive issues like diarrhea, bloating, or abdominal pain, while others report fatigue, anemia, joint pain, or skin conditions like Dermatitis herpetiformis. Surprisingly, 50% of patients continue to experience symptoms even on a gluten-free diet.

Risk Factors and Long-Term Impact

Celiac Disease runs in families, with first-degree relatives carrying a 10% risk. Left untreated, it can lead to severe complications such as osteoporosis, infertility, epilepsy, heart disease, and a higher risk of bowel cancer. However, early diagnosis significantly reduces these risks.

Diagnosis and Management?

Diagnosis typically involves blood antibody tests, biopsies, and genetic testing. Advanced molecular tools like Bosphore Celiac HLA DQ2/DQ8 Detection Kit v1 enable precise identification of genetic susceptibility through blood or buccal swab samples.

While genetic tests can’t confirm the disease alone, they can rule it out when susceptibility alleles are absent.

Currently, the only effective treatment is a lifelong gluten-free diet, which helps heal intestinal damage and improve symptoms. Raising awareness about early detection and strict dietary management is key to preventing long-term complications and enhancing the quality of life for those with Celiac Disease.?

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