Can hyaluronic acid, the “star” ingredient in medical aesthetics, continue to be “star”?

In recent years, with the advent of the "synthetic biology" era, biotechnology has been continuously upgraded, and the hyaluronic acid industry has also ushered in a new stage of change. The domestic hyaluronic acid industry chain has continued to develop, among which the most representative are biopharmaceutical companies such as Huaxi Biology and Freda.

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According to the report of Frost & Sullivan, the global hyaluronic acid raw material market sales reached 720 tons in 2021, of which 82% came from China, and China's Huaxi Biology alone accounted for 44% of the global sales. It is expected that in the next five years, the global hyaluronic acid raw material market will maintain a compound growth rate of 12.3%, reaching a market sales volume of 1285.2 tons in 2026.

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With the annual improvement of hyaluronic acid production level, hyaluronic acid has become a hot topic in the field of skin care, and has been more and more widely used in the fields of medical beauty and cosmetics. This article briefly sorts out its application research in the fields of medical beauty and cosmetics, hoping to help the further innovative application of hyaluronic acid.

Hyaluronic acid (HA), also known as hyaluronic acid, is a linear glycosaminoglycan (GAG) composed of n-acetyl-d-glucosamine and diglucuronic acid. It is widely distributed in the extracellular matrix (ECM) of connective tissue of most vertebrates. Hyaluronic acid is not a single component, but a basic component of the extracellular matrix of human dermis. It is a filler between cells and plays an important role in the morphology, structure and function of the skin.

The permeability and efficacy of hyaluronic acid depend largely on its molecular weight. Generally speaking, in the field of dermatology, substances greater than 500Da are difficult to be absorbed by the skin. Therefore, high molecular weight hyaluronic acid has very limited permeability through the skin and mainly stays on the surface of the skin to form a thin protective hydration layer. In contrast, low molecular weight hyaluronic acid can penetrate into the epidermis and does not rely on passive diffusion through the epidermis, but may be promoted by active transport.

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The hyaluronic acid technology provided by KNIKBIO uses raw materials such as cow bone powder, chicken bone powder, and fish bone powder, and uses its own cultured strains to produce hyaluronic acid with high yield. At present, strains and technologies can be provided. If you are interested, please contact [email protected].