CúRAM Celebrates 11th Researcher to Receive the Julia Polak European Doctoral Award

Dr Amir M. Alsharabasy is the eleventh researcher at CúRAM to receive the Julia Polak European Doctoral Award. The award is given by the European Society For Biomaterials - ESB council to candidates who can demonstrate receipt of a high standard of research education and training at a European level in biomaterials and tissue engineering and who are able to produce scientific results deserving of recognition by being published and accepted in high-quality journals and conferences.

To this end, candidates will have had to spend at least one month of research work in a country outside the country of their home institution, have produced at least two peer-reviewed international publications as the first author and have participated at least twice at an international scientific meeting as presenting author, during their PhD.

Amir obtained his PhD in biomedical engineering in 2023 from the 爱尔兰国立高威大学 , having completed an MSc in Biological & Bioprocess Engineering at 英国谢菲尔德大学 UK and his MSc in Biochemistry from Helwan University Cairo , Egypt. His research interests are the development of reactive oxygen and nitrogen species shielding materials for different biomedical applications. In CúRAM, he is working under the supervision of Prof. Abhay Pandit on the development of nitric oxide scavenging hydrogels, and funded by the Government of Ireland Postdoctoral Fellowship Programme. He explains more about his work below.

What kind of research are you involved in?

I am involved in research at the intersection of biomedical engineering and material science, with a strong focus on developing advanced biomaterials for therapeutic applications. My work centers on modulating reactive oxygen and nitrogen species (RONS), including the development of nitric oxide (NO)-scavenging hydrogels and NO-releasing materials. Additionally, I explore the chemistry and biology of reactive oxygen species (ROS) to design materials that shield tissues from oxidative stress, addressing critical challenges in cancer treatment, wound healing, and tissue engineering.

How does your approach differ from current methods?

My approach focuses on the dynamic modulation of gasotransmitters, particularly nitric oxide (NO), as well as addressing the roles of reactive oxygen and nitrogen species (RONS) in health and disease. Gasotransmitters like NO are crucial signalling molecules involved in various physiological and pathological processes, yet their dysregulation can contribute to conditions such as cancer and chronic wounds.

To address this, I develop biomaterials that either scavenge excessive NO or deliver it in controlled amounts. For example, I have synthesized NO-scavenging hydrogels that mitigate NO's harmful effects in the tumour microenvironment, reducing the pro-cancerous effects of excessive NO in case of breast cancer. Additionally, I work on the chemical synthesis of novel compounds for precise NO delivery. This integration of gasotransmitter biology with material science sets my work apart from conventional approaches that often lack the specificity and multifunctionality required to address complex biochemical imbalances.

What do you think is the most important thing for people to know about your research?

The most important aspect of my research is its focus on gasotransmitters, such as nitric oxide (NO), as a central strategy for addressing medical challenges. NO is a key player in both physiological signalling and pathological conditions, making its modulation a powerful therapeutic tool. My work involves designing advanced biomaterials that either neutralize excessive NO or deliver it in a controlled manner to restore biochemical balance. By targeting the role of NO and its interplay with reactive oxygen species, my research provides innovative solutions that enhance the precision, efficacy, and safety of treatments for conditions like cancer and chronic wounds.

Why did you embark on a research career?

I have always been fascinated by the interplay between materials and biological systems, particularly the chemistry and biology of reactive species like NO and ROS. The potential to harness these molecules for therapeutic applications has driven my passion for research. My academic journey, spanning biochemistry and biomedical engineering, has equipped me with an interdisciplinary perspective to tackle complex medical problems. Research allows me to explore innovative solutions, contribute to scientific advancements, and make a meaningful impact on patient care, which is both challenging and deeply rewarding.

What does this award mean to you?

Receiving the Julia Polak European Doctoral Award is a profound honour that recognizes my contributions to the field of reactive species-modulating materials. This award validates the significance of my work in addressing critical medical challenges through innovative biomaterials. It also motivates me to continue pushing boundaries in this area and acknowledges the invaluable support of my mentors, collaborators, and institutions along the way.

How do you like to use your time away from work?

Outside of work, I enjoy engaging in activities that help me recharge and stay balanced. Reading about history and philosophy is a particular passion of mine, as it broadens my understanding of the world and provides new perspectives. I also practice karate, which keeps me physically active while fostering discipline and focus. Additionally, I enjoy watching comic shows, which provide light-hearted entertainment and a great way to unwind.