?? Brain Health Innovations ??

OSCILLOSCAPE, LLC invented systems and methods for feedback-based audio/visual neural stimulation. Publication NumberWO/2024/137261

REDENLAB PTY. LTD invented systems and computer implemented methods for assessing brain health. One method may comprise: receiving an audio recording of sounds made by a participant; determining, from the audio recording, a textual representation of at least one sound made by the participant; providing the audio recording to an acoustic analysis model; receiving from the acoustic analysis model, a speech quality dataset comprising one or more speech quality metric(s); providing the textual representation to a text analysis model; receiving from the text analysis model, a speech content dataset comprising one or more speech content metric(s); and determining, from the speech quality dataset and the speech content dataset a speech score associated with the participant; wherein the speech score is indicative of a brain health of the participant. Publication Number WO/2024/130331

CITY OF HOPE invented novel adeno-associated virus (AAV) vectors in nucleotide and amino acid forms and uses thereof are provided. The isolates show specific tropism for certain target tissues, such as blood stem cells, liver, heart and joint tissue, and may be used to transduce stem cells for introduction of genes of interest into the target tissues. Certain of the vectors are able to cross tightly controlled biological junctions, such as the blood-brain barrier, which open up additional novel uses and target organs for the vectors, providing for additional methods of gene therapy and drug delivery. Application Number 18486682

RESONAIT MEDICAL TECHNOLOGIES PTY LTD invented a brain stimulation method and system for use on a mammal. The system includes: an electroencephalogram (EEG) headset (110) having sensors for detecting an electrical signal of a patient, and an EEG processing device (120) for determining a stimulation protocol based on that electrical signal. The EEG processing device (120) includes: a brain state inference module (124) for determining an inferred brain state of the patient; and a learning module (126) for learning the stimulation protocol based on the detected electrical signal and the inferred brain state. The system also includes a neuromodulator (130) for delivering stimuli to the patient based on the stimulation protocol. Publication Number WO/2024/130330

The Regents of the University of California invented compounds which increase γ-oscillations in the brain. The disclosure further relates to methods of treating neurodegenerative diseases or disorders with the compounds disclosed herein. Application Number 18287586

KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY - ACADEMIC COOPERATION FOUNDATION invented MAGNETIC RESONANCE IMAGING DEVICE AND METHOD FOR PRECISELY MEASURING CEREBRAL OXYGEN METABOLISM.

Beijing Tiantan Hospital, Capital Medical University Yangzhou University invented a mutated Csf1r gene. The mutated Csf1r gene is obtained by changing the 2557th nucleotide of a Csf1r gene from C to A, leading to obtain a mutated protein encoded by the mutated Csf1r gene substitute the 853rd amino acid from proline to threonine. The mutated protein, expression vectors, recombinant viruses, recombinant cells, recombinant bacteria, or recombinant vectors are also disclosed. A method for constructing a murine model with mutations in Csf1r gene. This method includes introducing the targeted vector containing the mutated Csf1r gene into mouse embryonic stem cells, followed by injection into blastocysts to generate F0 generation mice. The F0 generation mice are then bred with mice that specifically express Cre enzyme in tissues, followed by screening. The constructed murine model has significant applications in studying the pathogenic mechanisms of brain diseases caused by microglial cell dysfunction and screening valuable medicine for treating brain diseases. Application Number 18545693.