Biweekly Research News Digest

This newsletter is designed to share with you research news in various fields where applications of gene sequencing can be found. It will share research findings from Novogene’s customers. By sharing insights from the most prestigious research teams, it is intended to call your attention to the latest applications of sequencing in life sciences and biomedical research and inspire your research.

I am delighted to welcome all of you back to the Biweekly Research News Digest. This week, we will delve into the realm of gut microbiota and explore the impact of gut microbiota on human health.

Sequencing plays an important role in the five articles featured in this newsletter. In those articles, you will see 16S rDNA sequencing, metagenomic sequencing, RNA-seq and ChIP-seq used in well-designed research. They are used either independently or in combination with each other or with research methods such as metabolome analysis, proteomic analysis, and DNA-protein interactions analysis. Working together, they enhanced our understanding of gut microbiota.

Revealing the Antiviral Effect?of JNCC with Metagenome Profiling and Metabolome Analysis

Researchers from Chinese Academy of Agricultural Sciences?explored the antiviral effect of natural plant nanocrystalline cellulose (NCC) in animals.?They used?honey bees as model organism?and conducted experiments with those?infected by?Israeli Acute Paralysis Virus (IAPV). Their?study demonstrated that JNCC helped to contain the proliferation?of the virus?and improve gut health of?the infected bees. They did metagenome profiling and metabolome analysis?and further specified underlying mechanisms.?Their?findings suggest that JNCC could be a candidate antiviral therapy.

Read More

Exploring HP1021's Role in H. pylori's Response to Oxidative Stress

Helicobacter pylori‘s?response to oxidative stress has not been well understood. In?a recent article published in Nature Communications, a joint research team composed of German and Polish?scientists presented their research on this issue. They combined transcriptomic, proteomic and DNA-protein interaction analyses to study?the redox switch protein HP1021?regulon. Their findings suggest that HP1021 influences H. pylori’s response to oxidative stress. The team specified in details the mechanisms underlying the process, including both the conventional ROS response pathways and the less typical ones.

Read More

Gut-Lung Axis in Newborns: Unveiling the Role of AMPs in Influencing Lung Injury

Antimicrobial peptides (AMPs) play an important role in regulating microbiota. Yet how microbiota homeostasis is maintained when there are inflammatory stimuli is understudied. Scientists from Boston Children's Hospital and the University of Alabama at Birmingham studied this issue and published their findings in Microbiome. They did experiments with neonatal mice and uncovered a gut-lung axis that influences lung injury in newborns. They demonstrated that intestinal AMP expression impacts intestinal microbiota and thereby influencing lung injury. Their findings suggested that AMP expression might be targeted to reduce the negative effects of hyperoxia exposure.

Read More

New Study Reveals Pet Cats' Impact on ARGs in the Human Gut

It is widely recognized that companion animals help to maintain the physical and mental health of their owners. Yet how the antibiotic resistome carried by companion animals influence their owners remains to be explored. Researchers from well-known universities and hospital in China utilized metagenomic analysis to study the issue and shared their findings in Micrbiome. They compared the antibiotic resistance genes (ARGs) in cat and human gut and found that cat owners had a much higher abundance of aminoglycoside resistance genes than non-owners did. They also reported a positive correlation between ARG abundance and the frequency of cat activity in the living environment. Their study shows that cats may influence ARGs in the human gut.

Read More

Research Reveals the ?Association between an Oral Pathobiont and Colorectal Cancer

Researchers investigated the relationship between oral pathobionts and colorectal cancer (CRC). In a recent study published in Gut Microbes, a collaborative research team from multiple French research institutions studied the Gram-positive anaerobic coccus Parvimonas micra and identified two phylotypes (A and B) with distinct characteristics. They reported that P. micra phylotype A is closely related to CRC and demonstrated that both in vitro and in vivo, there was strong correlation between P. micra phylotype A and DNA methylation alterations in genes involved in ?tumor suppression, oncogenesis, and epithelial–mesenchymal transition. Their findings suggest a potential role for P. micra in the carcinogenic process.

Read More

Enjoyed the research news? Share the newsletter with those who might also be interested in it!

About Novogene

Novogene is a leading company that applies advanced molecular biotechnology and high-performance computing in the research fields of life science and human health. Since its establishment in March 2011, Novogene has been dedicated to becoming a global leader in offering genetic science services and technology products. The company has successfully established cutting-edge platforms for high-throughput, large-scale gene sequencing, and high-performance computing. With a strong global presence, Novogene has provided its services to more than 7,000 customers worldwide, spanning 90 countries and regions across six continents. As of June 2023, Novogene has made significant contributions to the scientific community, co-publishing and/or being acknowledged in over 20,000 articles in the Science Citation Index. These publications have collectively garnered an impressive accumulative impact factor of 120,000+.

If you are interested in the sequencing services provided by Novogene and would like to get further information, please reach us here.