Biointron Weekly Reports
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?? Biointron is at the Antibody Engineering & Therapeutics Asia 2024! Join us at this premiere event in Kyoto, Japan on October 21-23, 2024. Meet us at Booth #15!?
Biointron’s Q3 2024 Antibody Industry Report is out now! Dive into the latest trends, breakthroughs, and insights shaping the antibody industry. Gain exclusive insights into:?
Thank you to everyone who came to visit us at Festival of Biologics 2024 – Europe last week! ?? If you missed out, don’t worry – you can reach our expert team at [email protected] or (732) 790-8340.?
In our latest episode of the new Antibody ABCs video series, we define?high-throughput expression.?Watch the playlist here.?
This Week’s News?
Trends – Further than ADCs??
Recently, we have seen exciting developments in the antibody-drug conjugate (ADC) space, from cloud computing to radioisotopes. ?
This month, BioCorteX announced a breakthrough in collaboration with Google Cloud technology by integrating large biological data and processing massive datasets rapidly. They discovered a crucial link between the tumor microenvironment and ADC efficacy, potentially transforming the landscape of personalized cancer therapy. This discovery could significantly improve the success rate of clinical trials and lead to more effective treatments for a wider range of patients.?
Besides machine learning, researchers are using antibodies with radioisotopes in a bid to more precisely deliver radiation to cancers and tumors. Several companies are looking to radiolabeled antibody-drug conjugates (rADCs) to bypass these side effects of radiation treatments for cancer such as fatigue, hair loss, nausea and skin irritation. These rADCs would deliver radiation only to cancer cells without affecting healthy ones, speed up treatment times and enable lower doses than traditional therapies. Companies working on these drugs include:?
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A recent review describes the need for radiolabeled ADME (Absorption, Distribution, Metabolism, and Excretion) studies for ADCs if new linkers and payloads are used that have never been used in humans before as these studies provide valuable information on the pharmacokinetic properties, optimal dosing regimen, and potential safety concerns. However, clinical radiolabeled ADME studies are not recommended where patients are treated for life threating diseases like for indications in oncology.?
Meanwhile, a recent paper describes exo-cleavable linkers for ADCs. Finding linkers that both enhance circulatory stability and enable effective tumor payload release remains a challenge, with the conventional valine-citrulline (Val-Cit) linker associated with several inherent drawbacks, including hydrophobicity-induced aggregation, a limited drug–antibody ratio (DAR), and premature payload release. Here, researchers have designed an exolinker approach, repositioning the cleavable peptide linker at the exo position of the p-aminobenzylcarbamate moiety, resulting in enhanced stability and therapeutic efficacy.
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Upcoming Events?
Next month, Biointron will be exhibiting at two conferences!?
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Learn more about Biointron at www.biointron.com, or contact us at [email protected] and +1 (732) 790-8340.