BIOCELL Journal Vol.48, No.12, 2024 is now available online
Tech Science Press
TSP publishes online periodicals and books, also hosts academical conferences.
The December 2024 issue (Volume 48, Issue 12) of BIOCELL is now available online. This issue features three editor-selected review articles that spotlight cutting-edge advancements in key areas of research, including targeting the cholangiocarcinoma microenvironment, the pathological interplay between type 2 diabetes mellitus and Parkinson’s disease, and the therapeutic potential of targeting the cancer cell cycle. Below is a detailed overview of the highlighted articles in this issue. We hope these insights into the latest developments in the field provide valuable perspectives and practical references for your research. We warmly welcome your readership and feedback.
ARMAND N. YAZDANI, MICHAELA PLETSCH, ABRAHAM CHORBAJIAN, DAVID ZITSER, VIKRANT RAI*
Mixed cholangiocarcinoma is a rare and highly aggressive form of biliary epithelial cell neoplastic proliferation, accounting for up to 20% of primary liver cancers. It is the second most common primary liver malignancy, with a five-year survival rate of less than 10% at diagnosis, and it is closely associated with various inflammatory diseases. Recent discoveries and insights into the tumor microenvironment have opened new avenues for targeted therapies in cholangiocarcinoma. Specifically, novel pharmaceuticals, including cell-based vaccines, tumor-associated neutrophils, and hepatic stellate cells, show promise as potential therapeutic targets.
This review explores emerging pharmaceutical therapies aimed at the cholangiocarcinoma microenvironment and the chemokine pathways involved in its pathogenesis, while also providing a risk-benefit analysis of the proposed treatment options. Future research should focus on optimizing the efficacy of tumor protein vaccines such as MUC1 and WT1, particularly by investigating the potential of combining these vaccines with other immunotherapeutic strategies, such as immune checkpoint inhibitors.
TINGTING LIU#, XIANGRUI KONG#, JIANSHE WEI*
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by persistent hyperglycemia. In recent years, an increased risk of Parkinson’s disease (PD) has been observed among individuals with T2DM. However, the molecular mechanisms underlying the interaction between T2DM and the pathogenesis of PD remain not fully elucidated. This review summarizes some of the shared pathophysiological mechanisms, including genetic risk factors, hyperglycemia, insulin resistance (IR), inflammation, mitochondrial dysfunction, oxidative stress, autophagy, and advanced glycation end products (AGEs), which independently or synergistically contribute to the onset and progression of both T2DM and PD. Additionally, the review compiles studies investigating the relationship between T2DM and PD, which may provide new insights for alternative therapeutic strategies for both diseases.
GARIMA SINGH#, SONIKA KUMARI SHARMA#, NEELU MISHRA, AASTHA SONI, MANSHI KUMARI, SAMARENDRA KUMAR SINGH*
领英推荐
Recent in-depth studies on cancer cell susceptibilities have revealed the therapeutic potential of selectively targeting the cell cycle in malignant cells. This review focuses on the major cell cycle dysregulations in cancer cells and introduces the latest developments in anticancer agents targeting cell cycle factors, which are either in clinical practice or in clinical trials. Given the increasing drug resistance observed in cancer patients, the article also explores mechanistic insights into potential therapeutic strategies targeting these cell cycle factors. Additionally, the review outlines the future research directions required to develop new therapies and optimize existing ones for maximum efficacy.
About the journal
BIOCELL is an international, peer-reviewed, open access journal on molecular and celluar biosciences. It publishes papers of the highest quality from all areas of cell biology, encouraging those that shed light on the mechanisms underlying fundamental cell biological processes, which creates an indispensable reading and publishing area for all scientists, researchers, clinicians, and teachers in colleges and universities. The journal welcomes high quality?original research articles, review papers, communications, perspectives, commentaries, etc. to stimulate the interest of the broad readership of the journal. Topics of interests include but are not limited to:
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