BioAscent's reputation as GPCR drug discovery experts validated by project success, customer feedback

BioAscent is an integrated drug discovery CRO with extensive experience across a wide range of?target classes, including GPCRs.?With a vast?background in big pharma, biotech, and academia, our team has a median drug discovery experience of 15 years. Currently, almost 50% of our target portfolio are GPCR projects, encompassing bespoke lead characterisation projects, through to fully integrated multi-FTE, hit-to-lead?and lead optimisation programmes.

Thanks to our history, the expertise of our scientists and recent project successes, our CRO-leading capabilities are increasingly recognised and relied upon by a growing?number of biotech and pharma customers engaged in GPCR drug discovery.

Proven expertise in supporting customer projects:

"Our project against a novel GPCR target has been a career highlight. We've worked closely with BioAscent from the initial assay development and screen, through hit confirmation, hit-to-lead and lead-optimisation, to the point where we have two preclinical candidates. We asked BioAscent to make some really challenging compounds to support our SAR hypotheses, and without the?expertise, initiative and tenacity of the BioAscent chemistry team, this project would not have succeeded. In summary, BioAscent has been the chemistry CRO I've worked with." Director, Medicinal Chemistry, Biotech

"The BioAscent biosciences team worked as independent contributors, suggesting and successfully developing assays for a novel GPCR target, and deploying these to support rapid design-make-test cycles. As well as supplying assays and data of extremely high quality, the initiative the BioAscent team showed when designing and interpreting experiments was a critical factor in the success of this project. Ours was very much a team of intellectual equals, and this intellectual collaboration was very much a driving force behind the success of this programme."?Head of GPCR Pharmacology, Biotech

CRO-leading GPCR drug discovery expertise

The team has a wealth of experience in running GPCR projects, encompassing bespoke lead characterisation projects, through to fully integrated multi-FTE, hit-to-lead and lead optimisation programmes.

• Fully integrated drug discovery projects:?streamlining the development and management of your compounds
• Assay development, optimisation and screening:?using all major label-based, as well as label-free,?GPCR assay technologies
• Stable GPCR cell-line generation:?tailored generation of stable cell lines to meet the specific needs of your project
• Medicinal chemistry:?extensive experience in designing and synthesising compounds targeting GPCRs
• In silico/computational chemistry approaches:?accelerating GPCR drug discovery by employing a range of structure and ligand-based in silico techniques

GPCR hit discovery approaches:

• Target-based approaches
• Phenotypic screening
• HTS
• Virtual screening
• Mode of action studies

Find out more about BioAscent's GPCR drug discovery expertise here.

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