Bifidobacterium longum subsp. longum Remodeled Roseburia and Phosphatidylserine Levels, Ameliorated Intestinal Disorders and liver Metabolic Abnormali

Bifidobacterium longum subsp. longum Remodeled Roseburia and Phosphatidylserine Levels, Ameliorated Intestinal Disorders and liver Metabolic Abnormali

Introduction

Obesity is mainly caused by the imbalance between?energy intake and metabolism, which is easy to cause?hypertension, type 2 diabetes and cardiovascular disease.?Supplement of probiotics improve the metabolic disorder of?the host by regulating the intestinal flora, playing a role in?inhibiting obesity. This study used the Bifidobacterium?longum subsp. longum BL21 to intervene in high-fat feed?induced obese mice, exploring the effect of BL21 on obese?mice, providing efficacy support for BL21 in controlling?weight, lowering blood lipids, and regulating intestinal?microbiota.

Study Design

?Main Results

?BL21 attenuated weight gain

Total Cholesterol

Triglycerides

Low-density?lipoprotein cholesterol

?BL21 showed the lipid-lowering activity
BL21 ameliorated fat vacuolization in liver cells and epididymal fat?accumulate ion, protected liver
?BL21 restored the gut?microbiota diversity
Restored F/B
BL21 regulated?the gut microbiota?disorder(Increased?Akkermansia)

Conclusion:?

  • Continuous intervention with BL21 (1 B CFU/d for 8 weeks can effectively suppress obesity caused by a high-fat diet
  • BL21 has lipid-lowering activity and balancing intestinal effect

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