Beyond "One size fits all": a deep dive into patient stratification
Inoviem Scientific
Creative Technologies for Efficient Therapeutics, Precision medicine
Unlocking a new era of personalized medicine, patient stratification is transforming healthcare by grouping individuals based on unique biological characteristics.
What is patient stratification and why is it important?
We know an efficient treatment works only on a subset of patients. Without patient stratification, this crucial benefit might be obscured in a larger, general population study.
Here's why patient stratification is vital in both preclinical and clinical development:
How the identification of responder patients is useful in preclinical development??
Even before human trials begin, patient stratification plays a crucial role. By using ex-vivo human material, researchers can utilize genetic analysis, disease models, and other techniques to identify potential responders in preclinical studies. This targeted approach helps select the most promising drug candidates for further clinical evaluation.?
In clinical trials?
During clinical trials, patient stratification ensures participants are categorized based on relevant factors like genetic makeup, disease biomarkers, and disease stage. This allows researchers to:?
Paving the way for a future where drug development is truly personalized with PIMS? technology.
PIMS?: revolutionizing patient stratification for personalized medicine
PIMS? (Physiological Intermolecular Modulation Spectroscopy) is a powerful biophysical tool that deciphers responders from non-responders to various drugs. This label-free platform analyses tissue or cell response upon exposure to exogenous molecules.?
Unlocking personalized medicine
By leveraging established principles (Rayleigh Light Scattering and Molecular Resonance), PIMS? generates a unique "fingerprint" reflecting a patient's potential drug response. This personalized approach streamlines clinical trials, enhances treatment efficacy, and minimizes side effects.
领英推荐
Identifying the ideal patient cohort
PIMS? helps identify patient subgroups most likely to benefit from a specific treatment, optimizing clinical development. Studies have shown high reliability (around 96%) in predicting patient response. Compatible with human tissues (blood, biopsies), PIMS? analyses a patient's unique molecular makeup to predict their response
PIMS? applications:
Beyond PIMS?: Unveiling mechanisms and companion diagnostics
PIMS? excels at patient stratification, but understanding the underlying response mechanisms is crucial. There is a need to understand the clinical Mechanism of Action (cMoA) and the response-specific signalling pathway (RSSP) in patients. Nematic Protein Organization Technique (NPOT?) and ex-vivo pharmacology assays are typically used for this purpose. Once the molecular interactions between responders and non-responders are identified, these findings pave the way for defining clinically significant prognostic biomarkers.
Ultimately, these success predictors are used for companion diagnostic development, leading to:
By combining PIMS? with other techniques, Inoviem can unlock the full potential of personalized medicine, leading to more effective and targeted therapies.?
To learn more about how the PIMS? and the NPOT? platforms can support precision medicine drug development: download PIMS? case story
Events | Join us on