Associations Between Avocado Intake and Measures of Glucose and Insulin Homeostasis in Hispanic Individuals With and Without Type 2 Diabetes:

Associations Between Avocado Intake and Measures of Glucose and Insulin Homeostasis in Hispanic Individuals With and Without Type 2 Diabetes:

Results from the Hispanic Community Health Study / Study of Latinos (HCHS/SOL)

MacKenzie K. Senn, Mark O. Goodarzi, Gautam Ramesh, Matthew A. Allison, Mariaelisa Graff, Kristin L. Young, Gregory A. Talavera, Amanda C. McClain, Tanya P. Garcia, Jerome I. Rotter, Alexis C. Wood


Study Overview

PUBLISHED: Nutrition Metabolism & Cardiovascular Diseases

CATEGORY: Type 2 Diabetes

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Background and Aims:

To investigate associations between avocado intake and glycemia in Hispanic/Latino adults.

Methods and Results

The associations of avocado intake with measures of glycemia were evaluated in a cross-sectional analysis of up to 14,591 Hispanic/Latino adults. Glycemia was assessed via: average glucose levels (hemoglobin A1c; HbA1c), fasting glucose and insulin, glucose and insulin levels after an oral glucose tolerance test (OGTT), and via calculated measures of insulin resistance (HOMA-IR, and HOMA-%β), and insulinogenic index. Associations between avocado intake and glycemia were assessed using multivariable linear regression models, which controlled for sociodemographic factors and health behaviors, and which were stratified by dysglycemia status.

In those with normoglycemia, avocado intake was associated with a higher insulinogenic index (β=0.17±0.07, P=0.02). In those with T2D (treated and untreated), avocado intake was associated with lower hemoglobin A1c (HbA1c; β=-0.36±0.21, P =0.02), and lower fasting glucose (β=-0.27±0.12, P=0.02). In the those with untreated T2D, avocado intake was additionally associated with HOMA-%β (β=0.39±0.19, P=0.04), higher insulin values 2-hours after an oral glucose load (β=0.62±0.23, P = 0.01), and a higher insulinogenic index (β=0.42±0.18, P=0.02). No associations were observed in participants with prediabetes.

Conclusions:

We observed an association of avocado intake with better glucose/inulin homeostasis, especially in those with T2D.


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