Applications of Oxazoline Ligands in Asymmetric Catalysis

Oxazoline ligands currently dominate in asymmetric synthesis, they have been extensively applied in a series of important metal-catalyzed enantioselective reactions.

Technical Notes:

Nickel/Photo-Cocatalyzed Asymmetric Acyl-Carbamoylation of Alkenes.[1]

Asymmetric Ni-Catalyzed Radical Relayed Reductive Coupling.[2]

Modular access to substituted cyclohexanes with kinetic stereocontrol.[3]

Enantioselective Electrocatalytic Cyanofunctionalization of Vinylarenes.[4]

Asymmetric Allylic C-H Alkylation via Palladium(II)/cis-ArSOX Catalysis.[5]

Available Ligands in BLDpharm.

1. PyOX Series

2. BOX Series

3. PHOX Series

4. SOX Series

References

[1] J. Am. Chem. Soc.?2020,?142, 2180.

[2] J. Am. Chem. Soc.?2020,?142, 13515.

[3] Science,?2022,?376, 749.

[4] J. Am. Chem. Soc.?2019,?141, 14480.

[5] J. Am. Chem. Soc.?2018,?140, 10658.