Application and Mechanism of Action of Healus Wound Gel in Chronic Wound Treatment
The treatment of chronic wounds has long been a significant challenge in clinical medicine. In recent years, with the advancement of wound care technology, debridement gel, as a new type of wound dressing, has shown remarkable clinical efficacy in the treatment of chronic wounds. This article will explore the mechanism of action of debridement gel and its application in chronic wound treatment from an academic perspective.
Composition and Characteristics of Debridement Gel
Healus Wound Gel are mainly composed of the following ingredients: Carboxymethylcellulose Sodium (CMC), Alginate, Glycerol, Lactate, and purified water. The synergistic effect of these components gives debridement gel unique physicochemical properties:
1.1High Water Absorption: Both CMC and alginate have strong hydrophilicity and can absorb large amounts of wound exudate(Hong et al., 2008).
1.2 Moisture Retention: The hydrophilicity of CMC helps maintain a moist wound environment (Kanikireddy et al., 2020).
Mechanism of Action of Gel
2.1 Autolytic Debridement
Autolytic debridement is one of the primary mechanisms of action of Healus Wound Gel. It promotes autolytic debridement of the wound through the following ways:
a) Maintaining Appropriate Moisture: Debridement gel can form a moist gel layer on the wound surface, providing an ideal environment for the autolytic process.
b) Softening Eschar: The moisturizing effect of the gel can soften eschar and necrotic tissue on the wound surface.
2.2 Antimicrobial and Anti-biofilm Action
Carboxymethylcellulose sodium has antimicrobial action (Wong and Ramli, 2014), antibio lm action (Ali et al, 2019) and promotes wound healing by restoring the normal structural and functional characteristics of the skin (Basu et al, 2018).
2.3 Promoting Cell Proliferation and Migration
The moist environment may also enhance cell proliferation, enzyme activation, growth factor secretion, and hormone regulation (Kanikireddy et al., 2020).
2.4 Balancing Wound Moisture
Healus Wound Gel has a dual action, capable of both absorbing excess exudate and providing moisture to dry wounds. This balancing effect is crucial for maintaining an optimal wound healing environment.
2.5 Restoring Normal Skin Structure and Function
领英推荐
Studies have shown that CMC can promote wound healing by restoring the normal structural and functional characteristics of the skin (Basu et al., 2018).
Clinical Application of Healus Wound Gel in Chronic Wound Treatment
3.1 Indications
The gel is suitable for various types of chronic wounds, including:
3.2 Clinical Effects
Multiple clinical studies have confirmed the significant effects of debridement gel in chronic wound treatment:
a) Reduction in Wound Area: Anscare series study involving 10 patients with chronic wounds showed that after using debridement gel for 2-20 weeks, the wound area reduced by 83.8%-100% (Nair et al., 2021).
b) Pain Reduction: The moist environment helps alleviate patients' pain sensation.
c) Autolytic Debridement Effect: Healus Wound Gel can effectively soften and remove necrotic tissue, promoting wound cleansing.
Conclusion
As a new type of wound dressing, debridement gel demonstrates significant clinical efficacy in the treatment of chronic wounds through its unique physicochemical properties and multiple mechanisms of action. It not only effectively performs autolytic debridement but also balances wound moisture, inhibits bacterial growth, and promotes cell proliferation and migration. Compared to traditional methods, debridement gel has better adaptability and fewer side effects. However, more large-scale, long-term randomized controlled trials are still needed to further validate its efficacy in different types of chronic wounds. With deepening research and accumulating clinical experience, debridement gel is expected to become an important tool in the field of chronic wound treatment, providing better treatment options for patients.
#debridement #Carboxymethylcellulose #Alginate #ChronicWoundTreatment
#OEM #ODM #Wound
References:
Wounds Asia 2021 | Vol 4 Issue 3 | ?Wounds Asia 2021
Wounds Asia 2023 | Vol 6 Issue 3 | ?Wounds APAC 2023