Analytical Chemistry Services
Genelife Clinical Research Pvt. Ltd.
Your Trustworthy Partner in Product Development
Collecting analytical chemistry data early in discovery is critical to your compound’s success. Whether you’re interrogating a small batch of hits or performing high-throughput quality control for novel chemical libraries, chiral separation and structural elucidation studies can clarify your hit compound's?structure and purification profile, allowing you to select and move your best candidate forward.?
Purification and Structural Elucidation Capabilities
You can always contract Genelife Clinical Research Pvt. Ltd. expert analytical chemistry team to perform stand-alone purification and structural elucidation studies and collect the critical data you need to progress your compound. But an integrated approach is better. ?
In a synchronized discovery workflow that has delivered several?clinical candidates and many patents to our clients, our analytical chemistry team works in concert with medicinal chemistry, biology, and formulation scientists to analyze and refine your assets. Data from each cycle informs the next, moving your compound seamlessly and efficiently towards lead candidate.
Analytical Chemistry Techniques
With expertise in numerous techniques, our analytical chemistry team can meet your most challenging requirements, from performing robust characterization to delivering routine and bespoke purification solutions, using technologies such as:
Preparative HPLC Purification
Our analytical chemistry team uses a range of reverse phase purification systems which combine standard UV-directed HPLC systems as well as mixed-mode trigger systems (UV, MS and/or ELSD). Focusing primarily on rapid turnaround of compounds from hit-to-lead and lead optimization projects, the analytical chemistry services team provides efficient separation solutions for a broad array of analytes with wide-ranging structural diversity from milligram (mg) to gram (g) scale.?
Our streamlined reverse-phase screening cascades predict appropriate focused gradients, providing greater resolution of the target and impurity peaks without increasing the total run time or requiring extensive method development on most compounds. With multiple dedicated reverse phase purification systems, we can easily accommodate individual medicinal chemistry samples, small arrays, and larger libraries of compounds without compromising workflow.
For samples requiring further method development or specialist downstream techniques, we can incorporate columns and mobile phases from our extensive portfolio in parallel with our supercritical fluid chromatography and flash chromatography systems. We can also apply solid phase extraction (SPE) for buffer removal. As a standard service, we freeze dry all samples after concentrating using centrifugal evaporation.
Supercritical Fluid Chromatography?
Supercritical fluid chromatography (SFC) services offer rapid enantiomeric separation of stereogenic mixtures. An essential component of validating the active conformations of most chiral compounds, the process also reduces drying time eliminating the solvent waste. When it comes to achiral separations, supercritical fluid chromatography also offers the advantages of speed and green chemistry. ?
Track Record of Candidates
Successful candidate development is directly related to the experience of scientists, investment in platform technologies and application of a translational approach.
Multiple SFC analytical and purification systems complement our chiral HPLC capabilities, creating a flexible approach to accommodate standard and unique requirements. Available on a milligram to multigram scale, our separation services follow processes that ensure the consistent safety and stability of your sample.
Quality Control Analytical Chemistry Services?
Establishing the purity and structure of novel test compounds and pharmaceuticals is critical to the success of drug discovery programs. Once synthesized and purified by separation scientists, compounds are processed by our analytical chemistry team, undergoing rigorous characterization and structural elucidation.?
Quality control (QC) studies determine if a sample is ready to progress to assay. Delivering quality compounds as efficiently as possible, QC analysts are key members of the analytical chemistry services team, helping reduce the design-make-test-analyse (DMTA) cycle of drug discovery.
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Our analytical chemistry team collaborates with many other discipline and activities, such as:
Nuclear Magnetic Resonance Spectroscopy
Whether you manufacture on site or externally, you need data that confirms the structure and purity of your potential pharmaceutical compounds and intermediates. Our team performs structural analysis of organic compounds using spectroscopic methods.
High resolution NMR spectroscopy is used extensively for structural analysis and characterization, distinguishing structural isomers and conformers, investigation of mixtures and quantitative analysis.
LC-MS Spectrometry?
Our analytical chemistry services employ a range of mass spectrometers coupled to HPLC, UPLC systems and analytical SFC systems to perform structural analysis, quality control, analysis of mixtures, and?metabolism identification.?The systems can be operated under a variety of conditions to maximize the result and provide the highest quality data. As a supplement to the mass spectrometer, we use range of detectors (PDA, ELS, CAD) to ensure that nothing in the chromatogram is overlooked.?
LC-MS is used extensively in our analytical chemistry services for analysis of chemistry and pharmaceutics screens, for physicochemical parameter measurements and any study that requires high throughput analysis. Acquiring MS data at high resolution enables us to achieve supplementary information regarding the molecular formula. Evidence is accumulated for the structure of a molecule combined with other methods such as:?
From this evidence, our Analytical Sciences team can generate a professional certification of analysis (CoA) document; this is often combined with pharmaceutics details of the solid form, for regulatory submission purposes such as?IND.
Library Quality Control Using High-Throughput Screening LC-MS
In the early stages of many projects, high-throughput screening (HTS) biology is a key component. Our analytics team supports?HTS biology?with the validation of hits through high-throughput liquid chromatography mass spectrometry (HTS LC-MS).
We also employ this process to analyze your collections, screening and validation of library components, and supporting chemistry through high-throughput chemistry analysis and metabolism screening.
Complementary Analytical and Spectroscopic Methods
The analytical sciences team at Genelife Clinical Research Pvt. Ltd. employs a range of techniques for characterization of compounds. The methods, available either internally or through our partnerships, include:
Applied according to your needs, these platforms and technologies lead to detailed proof of structure credentials (PoS) and more robust patents for your APIs.
For any further details please feel free to get connect with us at [email protected]?or visit our website www.genelifecr.com?
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