AMR Future Brief| How Have Advances in Regenerative Medicine Empowered the Healthcare Sector?

In regenerative medicine, cells, tissues, or genetic material are used to repair, replace, or rejuvenate damaged organs. Conditions such as Parkinson's disease, cardiovascular disease, Alzheimer's disease, renal disease, cancer, diabetes, and other chronic diseases have been treated and cured using this approach.?

Recent innovative advancements in the regenerative medicine sector include the utilization of 3D bioprinting technology, which allows the creation of complex tissue structures layer by layer, providing customized solutions adapted to individual patient requirements. Stem cell therapy, where stem cells are used to repair and regenerate damaged tissues, is another exciting development. Furthermore, advances in gene editing technologies, such as CRISPR-Cas9, show promise in altering genes and molecularly correcting genetic disorders. These innovative methods have the potential to transform healthcare by offering new treatment options for a wide range of diseases.??

Rise in prevalence of chronic genetic disorders??

In recent years, the growing prevalence of chronic genetic disorders directly impacted the growth of the regenerative medicine sector by creating a larger demand for innovative treatments, that focus on repairing or replacing damaged tissues and organs through techniques such as stem cell therapy and tissue engineering, offering appropriate solution for individuals suffering from genetic disorders. Many people are diagnosed with these conditions. Therefore, the need for advanced regenerative therapies has become more urgent, driving research, investment, and development in the regenerative medicine field.??

For example, in July 2022, the National Heart Lung and Blood Institute granted $557,000 to Washington University to study the effectiveness of a newly engineered TRIM72 protein in regenerating vasculature and skeletal muscles in mice with diabetic critical limb ischemia (CLI). Thus, government investments in the form of research grants are anticipated to fuel growth in the global regenerative medicine sector in the future.????

The importance of stem cell therapy in the field of medical technology??

Nowadays, research in the central nervous system domain has progressed rapidly, with a considerable focus on the use of stem cells to treat various neurological conditions. Human blood and bone marrow stem cells (HSCs) have been extensively used in the extraction and production of hematopoietic stem cells (HSCs) for regenerative medicine purposes. Adult stem cells have regained prominence as a new reservoir of undifferentiated stem cells for various applications.??

Moreover, adult stem cells have a great potential for medical research and therapy, without the ethical concerns associated with embryo destruction, as opposed to embryonic stem cells. These cells exhibit indefinite division and the ability to differentiate into various specialized cell types, making them immensely valuable for regenerative medicine. For example, in April 2021, a collaboration between Ossium Health and ExCellThera Inc. showcased the increasing interest in using adult stem cells for medical purposes. Scientists anticipate discovering advanced opportunities for medical treatments by merging ExCellThera's cell expansion and rejuvenation technology with Ossium Health's bone marrow repository.??

In short, the increased interest in stem cell research, especially in adult stem cells, reflects the significant progress made in this field. These advancements give patients optimism and contribute to the growth of the biotechnology industry. In addition, innovations have the ability to change medical treatments by regenerating whole organs from a few cells, leading to new therapies and economic opportunities.??

How are recent advancements in stem cell research and regenerative medicine shaping the industry landscape???

Collaborative partnership: IASO Bio and Umoja??

On January 3, 2024, IASO Biotherapeutics, a company specializing in the development of advanced cell therapies and antibody products, formed a partnership with Umoja Biopharma, an immunotherapy company. The goal of this collaboration is to improve the effectiveness of cancer treatments and autoimmune diseases.????

In this collaboration, IASO Bio gains access to Umoja's RACR? platform, a technology activating cytokine receptors. This partnership aims to help IASO in developing two types of cell therapies using induced pluripotent stem cells (iPSCs) with chimeric antigen receptors (CARs). IASO takes charge of the advancement, manufacturing, regulatory processes, and commercialization of these products worldwide.??

On the other hand, Umoja will receive exclusive rights to use CAR cassettes for two specific targets in developing in vivo gene therapies, utilizing their VivoVec? technology for this purpose. This collaboration enables both companies to utilize each other's knowledge along with technologies to progress in developing novel cell and gene therapies for various medical conditions.??

Partnership agreement: CN Bio and Altis??

On January 23, 2024, CN Bio teamed up with Altis Biosystems, to focus on developing realistic human organ models for drug testing. Through this collaboration, Altis Biosystems' gut model and CN Bio's liver model will be combined to create a version of the human micro physiological system (MPS) for testing orally administered drugs. This combined model will enable researchers to better predict how well drugs work in human body.??

To conclude, recent advancements in regenerative medicine, including stem cell therapy, and gene editing, are transforming healthcare by offering personalized solutions for various diseases. The advent of next-generation human gut/liver in vitro models for advanced studies and enhancing CAR-T cell therapies for cancer and autoimmune diseases through innovative cell and gene therapy approaches is expected to show the bright future of the regenerative medicine sector.??

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Short description:??

Regenerative medicine utilizes stem cell therapy, 3D bioprinting, and gene editing technologies to treat diseases such as Parkinson's, diabetes, cancer, and cardiovascular disease. The rising prevalence of genetic disorders boosts demand for advanced therapies. Government funding and focus on adult stem cells drive innovation in the field. Furthermore, the development of advanced cell therapies and antibody products shows great potential in improving patient outcomes.????

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