AMR Future Brief| How is Bioinformatics Bringing New Aspects in Drug Discovery?
In the field of biology and medicine, bioinformatics has paved the way for the optimal research and development of personalized drugs. Bioinformatics is a multidisciplinary field that uses biology and computer science together. In other words, it is a study of patterns of DNA sequences and proteins that protect human health from several diseases. Researchers mainly use bioinformatics to look at the global picture of a biological system and develop new legal and forensic techniques that will be used to create a wide array of personalized medicine in the future. This hybrid science uses computers to analyze vast amounts of data that would be impossible for humans to recognize manually.??
A look into the rise of bioinformatics?
In the early 1960s, researchers worked to decipher the molecular sequences of proteins to identify the structure of the protein to understand how it works in cellular processes. After identifying the sequence of proteins, researchers connected it to the gene that encodes it. At that period, as computers were not used in this study, researchers assembled the protein sequences, analyzed them, and compared them manually on sheets of paper taped side by side.??
Researchers first used bioinformatics on a large scale in the human genome project, which ran from April October 1990 through April 2003. In this project, researchers from all around the world sequenced and mapped all of the 3.1 billion protein base pairs in the genes that together make the human genome.
Bioinformatics in precision medicine?
In recent years, bioinformatics has shown its prominence in medicine. This specialized branch of science analyzes a person’s genomic data, helping researchers identify specific mutations that would be driving the development of a particular disease. Such information can be used to tailor treatments and predict the response of drugs specifically for that person. Additionally, this tool can be used to develop new drugs and diagnostic tests as it can identify disease-causing mutations. For instance, by analyzing the genomes of different pathogens, bioinformatics can identify potential targets for new antimicrobial drugs . It can also help develop diagnostic tests that are more sensitive and specific than existing ones.??
QIAGEN’s AI-driven knowledge base in promoting drug discovery?
In February 2024, QIAGEN, a German-founded multinational provider of sample and assay technologies for molecular diagnostics announced the launch of its new AI-driven knowledge base to propel drug discovery in the pharma and biotech industries. This new solution is immensely helpful for researchers and bioinformaticians who are mostly looking for detailed knowledge graphs to fuel data-driven drug discovery. QIAGEN’s new biomedical KB-AI is manually curated and is widely known for its unparalleled quality and accuracy. This solution is designed to provide both high-quality and high-quantity biomedical relationship data for scientists and bioinformaticians, allowing them to generate new insights.??
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How are alliances made by top players transforming the industry dynamics???
The global bioinformatics industry is observing remarkable growth due to the rise in the demand for nucleic acid & protein sequencing in various applications of proteomics & genomics. The market is anticipated to manifest a noteworthy CAGR of 13.4% from 2020 to 2027. Several leading players in the domain have made alliances such as mergers, acquisitions, partnerships, and collaborations to foster the industry’s competitiveness. For example, in June 2023, Intus Biosciences, a leading microbiome research firm announced the acquisition of Pattern Genomics, a renowned developer of genome analysis software. With this acquisition, the companies aimed to design advanced machine-learning tools to generate high-resolution, strain-level bacterial microbiome data for clinical and environmental applications.??
In May 2022, ZS, a renowned professional services firm acquired Intomics, a leading bioinformatics and systems biology company to profoundly improve patient’s lives by developing innovative medicines. The companies aimed to combine artificial intelligence, deep data, and scientific expertise to accelerate drug discovery and improve the probability of success for innovative medicines.??
To conclude, the increase in the demand for personalized medicines among individuals globally is predicted to increase the use of bioinformatics in the healthcare sector in the ahead years. Furthermore, the increase in the adoption of advanced technologies in the healthcare industry across developing economies is expected to drive the domain to achieve new heights in the future.????
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