Alphafold2 is Already Changing Biology

Alphafold2 is Already Changing Biology

"Using AlphaFold, Beck and others at the MPIBP — molecular biologist Agnieszka Obarska-Kosinska and a group led by biophysicist Gerhard Hummer — as well as a team led by structural modeller Jan Kosinski, at the European Molecular Biology Laboratory (EMBL) in Hamburg in Germany, could predict shapes for human versions of the Nup proteins more accurately. And by taking advantage of a tweak that helped AlphaFold to model how proteins interact, they managed to publish a model last October that covered 60% of the complex3. It reveals how the complex stabilizes holes in the nucleus, as well as hinting at how the complex controls what gets in and out."

Please see: Nature | Vol 604 | 234-238 14 April 2022?

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