is ai good enough?

People ask me how to use ai for medical device product development, below is an example as to how we can use ai to prepare an early-stage literature survey. This is clearly not going to be at the level of a professional literature review from a subject matter expert, but this took less than 3 hours, cost around $30 (for 1 month access). I used Chat-GPT , Consensus and Jenni.ai .

So what do you think, is the result good enough? Not good enough?

"Risks" outweigh the benefits?

Benefits outweigh the risks?

Its just tech, its all about how we use it…

LMK what you think.

Step-by-Step

Objective: I need a summary of literature to support a business plan on the topic of “what benefit would early detection of dementia provide”

1.????? ChatGPT for initial prompt development

a.????? I am looking to learn more about the benefits of lifestyle and wellness and supplement changes in order to delay onset of cognitive decline, Alzheimer's and dementia. Please prepare a research topic and then a query for PubMed to search for relevant articles.

i.???? "The Impact of Lifestyle Modifications and Dietary Supplements on Delaying Cognitive Decline, Alzheimer's Disease, and Dementia: A Systematic Review"

ii.???? PubMed Query: (“cognitive decline” OR “Alzheimer's disease” OR dementia) AND (lifestyle OR wellness OR “dietary supplement” OR “nutritional intervention” OR “physical activity” OR “cognitive training” OR “sleep quality” OR “stress management” OR “social engagement”)

b.????? please pose it as a question

i.????? ChatGPT:? "Can lifestyle modifications and changes in dietary supplements delay the onset of cognitive decline, Alzheimer's disease, and dementia?"

2.????? Search Pubmed

search with PubMed Query from above (example below)

a.????? 5 years, RCT, free full- 846

b.????? 5 years, Meta-Analysis, free full- 623

c.????? 5 years, Systematic, free full- 1426

d.????? Total – 2526

Select all and save all results as Format Abstract

“Print to PDF” from the text file (mine was 3557 pages long)

3.????? Search Consensus with question from above:

a.????? Summary (paid):

These studies suggest that adherence to healthy dietary patterns, particularly the Mediterranean, DASH, and MIND diets, along with lifestyle changes such as physical activity and social engagement, can delay the onset of cognitive decline, Alzheimer's disease, and dementia, although some specific supplements may not have clinically significant effects.

b.??? Copilot (paid):

Research on the impact of lifestyle modifications and dietary supplements on cognitive decline, Alzheimer's disease (AD), and dementia has been extensive, focusing on the potential of various diets and nutrients to serve as preventive strategies against these conditions.

Key insights from the research papers include:

Higher adherence to the Mediterranean, DASH (Dietary Approaches to Stop Hypertension), and MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) diets is associated with less cognitive decline and a lower risk of Alzheimer's disease, with the MIND diet showing the strongest?associations1 ?2 ?4 ?6 ?9 .

Healthy dietary patterns characterized by high intake of plant-based foods, probiotics, antioxidants, soybeans, nuts, and omega-3 polyunsaturated fatty acids, and a low intake of saturated fats, animal-derived proteins, and refined sugars are linked to decreased risk of neurocognitive impairments and potentially delaying the onset of Alzheimer's?disease2 ?5 .

Specific components such as olive oil and possibly vitamin D supplementation and curcumin use have been suggested to be associated with less cognitive?decline1 ?4 .

While some dietary components and supplements have been studied, there is no conclusive evidence from systematic reviews that individual nutrient supplementation has clinically relevant effects on delaying the onset of cognitive decline in older?adults7 .

Lifestyle factors such as physical activity, sleep patterns, and social engagement, in combination with dietary patterns, have been recognized as contributors to the prevention or delay of cognitive decline and?dementia3 ?5 .

In conclusion, the synthesis of the research suggests that adopting healthy dietary patterns, particularly the Mediterranean, DASH, and MIND diets, along with an active lifestyle, may contribute to the prevention or delay of cognitive decline, Alzheimer's disease, and dementia. The evidence points towards the benefits of a holistic approach that includes diet, physical activity, and other lifestyle factors rather than relying on individual nutrient supplementation.

References: ?

1.?????? The Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diets Are Associated with Less Cognitive Decline and a Lower Risk of Alzheimer's Disease—A Review

2.?????? Nutritional patterns associated with the maintenance of neurocognitive functions and the risk of dementia and Alzheimer's disease: A focus on human studies.

3.?????? Nutrition, Physical Activity, and Other Lifestyle Factors in the Prevention of Cognitive Decline and Dementia

4.?????? Dietary Interventions to Prevent or Delay Alzheimer’s Disease: What the Evidence Shows

5.?????? Can Healthy Diets, Regular Exercise, and Better Lifestyle Delay the Progression of Dementia in Elderly Individuals?

6.?????? Dietary Patterns and Cognitive Decline: key features for prevention.

7.?????? Dietary interventions as a neuroprotective therapy for the delay of the onset of cognitive decline in older adults: Evaluation of the evidence

8.?????? Dietary patterns, cognitive decline, and dementia: a systematic review.

9.?????? Dietary Strategies and Supplements for the Prevention of Cognitive Decline and Alzheimer’s Disease

10.?? Nutritional interventions for brain health in patients with Alzheimer’s disease: An expert consensus

?c.????? (export the references? in csv and then “Print to PDf”)

4.????? Go to Jenni.ai

a.????? Put in your question and include an outline builder

b.????? Create a collection and put the PDF from pubmed and the PDF from consensus into the collection.

c.????? (outline should be built)

d.????? Up to look for Settings/Gears and check all options are selected (auto everything)

e.????? Select a spot at the beginning and hit Crt K

i.????? Select AI Commands

ii.????? Select write an introduction

iii.????? Review and make sure it is “very good enough”.

iv.????? Anywhere you think needs a reference, select the text, select site, review the options and select “add citation”.

v.????? Then go to a header section and then select AI commands (Crt-K) continue writing

vi.????? Copy sentences that need citations, hit Crt-K and then cite and then paste, it will search for citations from what you paste in the search box (notice that some have the excerpts from the paper)

f.??????? “Write the paper”

g.????? Export to .doc format

h.????? Result (about 90min)

Can lifestyle modifications and changes in dietary supplements delay the onset of cognitive decline, Alzheimers disease, and dementia?

Introduction

As the prevalence of cognitive decline, Alzheimer's disease, and dementia continues to rise, there is growing interest in lifestyle modifications and dietary supplements as potential strategies to delay the onset of these conditions. Research in this area is generating significant attention, and there is a pressing need to explore the potential impact of lifestyle changes and dietary supplements on cognitive health (Brink et al. 2019) (Domínguez et al. 2021)(Barnard et al. 2014) (Swaminathan and Jicha 2014). In this document, we will delve into the current understanding of the role of lifestyle modifications and dietary supplements in delaying cognitive decline, Alzheimer's disease, and dementia. We will examine the latest research findings and discuss the practical implications for individuals seeking to preserve their cognitive function as they age.

Exploring the Impact of Lifestyle Modifications on Cognitive Health

Numerous studies have investigated the association between lifestyle modifications and cognitive health, with promising results . Several factors have been identified as potential influencers of cognitive decline and the development of Alzheimer's disease and dementia . These factors include diet, physical activity, sleep patterns, and social engagement . Dietary intervention has been a major focus of research, with specific attention given to the Mediterranean diet, the Dietary Approaches to Stop Hypertension diet, and the Mediterranean-DASH Intervention for Neurodegenerative Delay diet.(Petersson and Philippou 2016)(Brink et al. 2019). Evidence suggests that higher adherence to these dietary patterns is associated with better cognitive scores and a lower risk of Alzheimer's disease(Fu et al. 2022)(Huang et al. 2023). For example, a systematic review of studies published up to 2019 found that higher adherence to the Mediterranean diet was associated with better cognitive scores in cross-sectional and longitudinal studies, as well as a lower risk of Alzheimer's disease in several longitudinal studies (Aridi, Walker, and Wright 2017)(Petersson and Philippou 2016).

Additionally, there is evidence to suggest that specific dietary components play a role in cognitive health . For example, olive oil, which is a key component of the Mediterranean diet, has been associated with less cognitive decline(Aridi, Walker, and Wright 2017)(2022)(Fu et al. 2022)(Fazlollahi et al. 2023) . Furthermore, regular physical activity has shown to have a positive impact on cognitive function and can potentially delay cognitive decline . Incorporating lifestyle modifications such as regular exercise, following a healthy diet, getting adequate sleep, and engaging in social activities may help delay the onset.(Sindi, Mangialasche, and Kivipelto 2015)(Andrade and Radhakrishnan 2009)(Zhao et al. 2018)(Domínguez et al. 2021).

The Role of Diet in Preventing Alzheimers and Dementia

Diet plays a significant role in preventing Alzheimer's disease and dementia . The Mediterranean diet, the Dietary Approaches to Stop Hypertension diet, and their combination have shown strong evidence for slowing cognitive decline and reducing the risk of Alzheimer's and dementia (2013)(Brink et al. 2019)(Aridi, Walker, and Wright 2017)(2019). These dietary patterns emphasize the consumption of nutrient-rich foods such as fruits, vegetables, whole grains, lean proteins, and healthy fats like olive oil . These diets have been associated with better cognitive scores and a lower risk of Alzheimer's disease in numerous studies? . Overall, lifestyle modifications that include following a healthy diet, engaging in regular physical activity, getting adequate sleep, and maintaining social engagement can potentially delay the onset of cognitive decline, Alzheimer's disease, and dementia (Domínguez et al. 2021)(Barnard et al. 2014). In conclusion, lifestyle modifications such as following a healthy diet, engaging in regular physical activity, and maintaining social engagement can potentially delay the onset of cognitive decline.

Can Changing Your Lifestyle Stave Off Cognitive Decline?

Changing your lifestyle by incorporating healthy dietary habits and engaging in regular physical activity can potentially delay the onset of cognitive decline, Alzheimer's disease, and dementia .

In addition to lifestyle modifications, the use of dietary supplements has also garnered attention in the effort to delay cognitive decline, Alzheimer's disease, and dementia. Numerous studies have explored the potential impact of various dietary supplements on cognitive health, and certain compounds have shown promise in this area.(Canhada et al. 2017)(Domínguez and Barbagallo 2016)(Domínguez and Barbagallo 2018)(Scarmeas, Anastasiou, and Yannakoulia 2018)

One of the most widely studied dietary supplements in relation to cognitive health is omega-3 fatty acids. These essential fatty acids, commonly found in fish oil, have been the focus of research due to their potential neuroprotective effects. Multiple studies have suggested that omega-3 fatty acids may help support cognitive function and reduce the risk of cognitive decline. For example, a systematic review and meta-analysis of randomized clinical trials reported a beneficial effect of omega-3 fatty acid supplementation on cognitive function in older adult(Zhang et al. 2015)(Bhatti et al. 2020)(Canhada et al. 2017)(Arora et al. 2023)s.

Another dietary supplement that has been investigated for its potential cognitive benefits is vitamin E. Some studies have found that vitamin E, a fat-soluble antioxidant, may have a protective effect against Alzheimer's disease. However, further research is needed to fully understand the impact of vitamin E supplementation on cognitive health.

Other dietary supplements, such as curcumin, ginkgo biloba, and certain vitamins and minerals, have also been studied for their potential role in delaying cognitive decline.(Joshi and Praticò 2012)(Bhatti et al. 2020)(Fata, Weber, and Mohajeri 2014)(Sarker and Franks 2018)(Browne et al. 2019)(Domínguez and Barbagallo 2018)(Domínguez et al. 2021) While the results are mixed and more evidence is necessary to establish conclusive recommendations, the exploration of dietary supplements as a complementary approach to lifestyle modifications for preserving cognitive function is an active area of research.

While there is substantial research indicating the potential benefits of lifestyle modifications and dietary supplements in delaying cognitive decline, Alzheimer's disease, and dementia, it is important to acknowledge the limitations and opposing viewpoints.

One of the challenges in assessing the impact of lifestyle modifications is the complexity of human behaviors and the multifactorial nature of cognitive health(Rivan et al. 2022)(Domínguez et al. 2019) (2019)(Anderson and Fowers 2020)(Scarmeas, Anastasiou, and Yannakoulia 2018). While studies have observed associations between specific dietary patterns, physical activity, and social engagement with cognitive function, establishing a direct cause-and-effect relationship is difficult. Additionally, individual variations in genetics, socioeconomic factors, and access to healthcare can influence the effectiveness of lifestyle modifications in delaying cognitive decline.(Domínguez et al. 2021)(Domínguez et al. 2019)(Sindi, Mangialasche, and Kivipelto 2015)(Zhao et al. 2018)(Canevelli et al. 2016)(Mangialasche et al. 2012)(Schelke et al. 2016)(Kamphuis and Scheltens 2010).

Nutritional Supplements and Their Effect on Brain Aging

Nutritional supplements have gained attention for their potential effects on brain aging and cognitive decline . Several studies have investigated the impact of various supplements on cognitive function and brain health . While some studies have shown positive effects of certain supplements, such as omega-3 fatty acids and vitamin E, on cognitive function and the risk of Alzheimer's disease, the overall evidence is mixed and more research is needed to fully understand their efficacy (Bhatti et al. 2020)(Canhada et al. 2017)(Domínguez and Barbagallo 2016). Some studies suggest that lifestyle modifications, including dietary changes and the use of certain nutritional supplements, may have the potential to delay the onset of cognitive decline and reduce the risk of Alzheimer's disease and dementia. However, it is important to note that the use of dietary supplements should be approached with caution.(Canevelli et al. 2016)(Swanson et al. 2021)(Barnard et al. 2014)(Sindi, Mangialasche, and Kivipelto 2015)(Schelke et al. 2016)

Conclusion

In conclusion, lifestyle modifications, including changes in dietary patterns and supplements, have shown promise in delaying the onset of cognitive decline, Alzheimer's disease, anddementia . While the evidence is still evolving and more research is needed, adopting a healthy diet such as the Mediterranean, DASH, or MIND diet, alongwith regular physical activity and social engagement, may help maintain cognitive function and reduce the risk of these conditions .

?

References

?

2013. "Mediterranean Diet, Cognitive Function, and Dementia: A Systematic Review"

2019. "Dietary Patterns and Cognitive Health in Older Adults: A Systematic Review" Journal of Alzheimer's disease 69 (2) : 595-596. https://doi.org/10.3233/jad-199002 .

2022. "Mediterranean Diet, Cognitive Function, and Dementia: A Syst..."

Anderson, R, Austen, and Blaine J Fowers. 2020. "Lifestyle behaviors, psychological distress, and well-being: A daily diary study."

Andrade, Chittaranjan, and Rajiv Radhakrishnan. 2009. "The prevention and treatment of cognitive decline and dementia: An overview of recent research on experimental treatments" Indian Journal of Psychiatry/Indian journal of psychiatry 51 (1) : 12-12. https://doi.org/10.4103/0019-5545.44900 .

Aridi, S., Yasmine, Jacqueline L. Walker, and Olivia Wright. 2017. "The Association between the Mediterranean Dietary Pattern and Cognitive Health: A Systematic Review" https://doi.org/10.3390/nu9070674 .

Arora, Sakshi, José A. Santiago, Melissa Bernstein, and Judith A. Potashkin. 2023. "Diet and lifestyle impact the development and progression of Alzheimer’s dementia" https://doi.org/10.3389/fnut.2023.1213223 .

Barnard, D., Neal, Ashley I. Bush, Andrea Ceccarelli, James Cooper, Celeste de Jager, Kirk I. Erickson, Gary E. Fraser, Shelli R. Kesler, Susan Levin, Brendan P. Lucey, Martha Clare Morris, and Rosanna Squitti. 2014. "Dietary and lifestyle guidelines for the prevention of Alzheimer's disease" https://doi.org/10.1016/j.neurobiolaging.2014.03.033 .

Bhatti, Kaur, Gurjit, Arubala P. Reddy, P. Hemachandra Reddy, and Jasvinder Singh Bhatti. 2020. "Lifestyle Modifications and Nutritional Interventions in Aging-Associated Cognitive Decline and Alzheimer’s Disease" https://doi.org/10.3389/fnagi.2019.00369 .

Brink, den, van, C, Annelien, Elske M. Brouwer‐Brolsma, A. M. Berendsen, and Ondine van de Rest. 2019. "The Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diets Are Associated with Less Cognitive Decline and a Lower Risk of Alzheimer’s Disease—A Review" https://doi.org/10.1093/advances/nmz054 .

Browne, Declan, Bernadette McGuinness, Jayne Woodside, and Gareth McKay. 2019. "Vitamin E and Alzheimer’s disease: what do we know so far? | CIA"

Canevelli, Marco, Flaminia Lucchini, Federica Quarata, Giuseppe Bruno, and Matteo Cesari. 2016. "Nutrition and Dementia: Evidence for Preventive Approaches?" Nutrients 8 (3) : 144-144. https://doi.org/10.3390/nu8030144 .

Canevelli, Marco, Flaminia Lucchini, Federica Quarata, Giuseppe Bruno, and Matteo Cesari. 2016. "Nutrition and Dementia: Evidence for Preventive Approaches"

Canhada, Leite, Scheine, Kamila Castro, Ingrid Schweigert Perry, and Vivian Cristine Luft. 2017. "Omega-3 fatty acids' supplementation in Alzheimer's disease: A systematic review" Nutritional neuroscience 21 (8) : 529-538. https://doi.org/10.1080/1028415x.2017.1321813 .

Domínguez, J., Ligia, and Mario Barbagallo. 2016. "Dietary Approaches and Supplements in the Prevention of Cognitive Decline and Alzheimer';s Disease" https://doi.org/10.2174/1381612822666151204000733 .

Domínguez, J., Ligia, and Mario Barbagallo. 2018. "Nutritional prevention of cognitive decline and dementia." https://doi.org/10.23750/abm.v89i2.7401 .

Domínguez, J., Ligia, Mario Barbagallo, Mariana I Mu?oz-García, Justyna Godos, and Miguel ángel Martínez‐González. 2019. "Dietary Patterns and Cognitive Decline: key features for prevention" Current pharmaceutical design 25 (22) : 2428-2442. https://doi.org/10.2174/1381612825666190722110458 .

Domínguez, J., Ligia, Nicola Veronese, Laura Vernuccio, Giuseppina Catanese, Flora Inzerillo, Giuseppe Salemi, and Mario Barbagallo. 2021. "Nutrition, Physical Activity, and Other Lifestyle Factors in the Prevention of Cognitive Decline and Dementia" https://doi.org/10.3390/nu13114080 .

Fata, Giorgio, Peter Weber, and M Hasan Mohajeri. 2014. "Effects of Vitamin E on Cognitive Performance during Ageing and in Alzheimer’s Disease"

Fazlollahi, Asra, Kimia Motlagh Asghari, Cynthia Aslan, Maryam Noori, Seyed Aria Nejadghaderi, Mostafa Araj‐Khodaei, Mark J. M. Sullman, Nahid Karamzad, Ali‐Asghar Kolahi, and Saeid Safiri. 2023. "The effects of olive oil consumption on cognitive performance: a systematic review" Frontiers in nutrition 10. https://doi.org/10.3389/fnut.2023.1218538 .

Fu, Jialei, Li-Juan Tan, Jung Eun Lee, and Sangah Shin. 2022. "Association between the mediterranean diet and cognitive health among healthy adults: A systematic review and meta-analysis"

Fu, Jialei, Li-Juan Tan, Jung Eun Lee, and Sangah Shin. 2022. "Association between the mediterranean diet and cognitive health among healthy adults: A systematic review and meta-analysis" https://doi.org/10.3389/fnut.2022.946361 .

Huang, Liyan, Tao Yang, Hui Chen, Xiao Chen, Jie Shen, Caifeng Zhao, Xin Xu, Mengjie He, Dafang Zhu, Ronghua Zhang, Min Yang, Yan Zheng, and Changzheng Yuan. 2023. "Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) Diet and Cognitive Function and its Decline: A Prospective Study and Meta-analysis of Cohort Studies" ?The ?American journal of clinical nutrition 118 (1) : 174-182. https://doi.org/10.1016/j.ajcnut.2023.04.025 .

Joshi, B, Yash, and Domenico Praticò. 2012. "Vitamin E in aging, dementia, and Alzheimer's disease"

Kamphuis, H, G, J, Patrick, and Philip Scheltens. 2010. "Can nutrients prevent or delay onset of Alzheimer's disease?"

Mangialasche, Francesca, Miia Kivipelto, Alina Solomon, and Laura Fratiglioni. 2012. "Dementia prevention: current epidemiological evidence and future perspective" https://doi.org/10.1186/alzrt104 .

Petersson, Sara, and Elena Philippou. 2016. "Mediterranean Diet, Cognitive Function, and Dementia: A Systematic Review of the Evidence" Advances in Nutrition 7 (5) : 889-904. https://doi.org/10.3945/an.116.012138 .

Rivan, Malek, Fatin, Nurul, Suzana Shahar, Nik Nur Izzati Nik Mohd Fakhruddin, Yee Xing You, Normah Che Din, and Roslee Rajikan. 2022. "The effect of dietary patterns on mild cognitive impairment and dementia incidence among community-dwelling older adults" Frontiers in nutrition 9. https://doi.org/10.3389/fnut.2022.901750 .

Sarker, Marjana, and Susan Franks. 2018. "Efficacy of curcumin for age-associated cognitive decline: a narrative review of preclinical and clinical studies" GeroScience 40 (2) : 73-95. https://doi.org/10.1007/s11357-018-0017-z .

Scarmeas, Nikolaos, Costas A. Anastasiou, and Mary Yannakoulia. 2018. "Nutrition and prevention of cognitive impairment" https://doi.org/10.1016/s1474-4422(18)30338-7 .

Schelke, W., Matthew, Katherine Hackett, Jaclyn L. Chen, Chiashin Shih, Jessica Shum, Mary E. Montgomery, Gloria Chiang, Cara Berkowitz, Alon Seifan, Robert Krikorian, and Richard Isaacson. 2016. "Nutritional interventions for Alzheimer's prevention: a clinical precision medicine approach" Annals of the New York Academy of Sciences 1367 (1) : 50-56. https://doi.org/10.1111/nyas.13070 .

Sindi, Shireen, Francesca Mangialasche, and Miia Kivipelto. 2015. "Advances in the prevention of Alzheimer's Disease" https://doi.org/10.12703/p7-50 .

Swaminathan, Arun, and Gregory A. Jicha. 2014. "Nutrition and prevention of Alzheimera€?s dementia" https://doi.org/10.3389/fnagi.2014.00282 .

Swanson, J., Chad, Yong Zhang, Shobha Dhadda, Jinping Wang, June Kaplow, Robert Lai, Lars Lannfelt, Heather Bradley, Martin Rabe, Akihiko Koyama, Larisa Reyderman, Donald A. Berry, Scott M. Berry, Robert J. Gordon, Lynn D. Kramer, and Jeffrey L. Cummings. 2021. "A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer’s disease with lecanemab, an anti-Aβ protofibril antibody" https://doi.org/10.1186/s13195-021-00813-8 .

Zhang, Xiaowei, Wen-Shang Hou, Min Li, and Zhenyu Tang. 2015. "Omega-3 fatty acids and risk of cognitive decline in the elderly: a meta-analysis of randomized controlled trials" https://doi.org/10.1007/s40520-015-0381-9 .

Zhao, Chen, James M. Noble, Karen Marder, Jacob S Hartman, Yian Gu, and Nikolaos Scarmeas. 2018. "Dietary Patterns, Physical Activity, Sleep, and Risk for Dementia and Cognitive Decline" Current nutrition reports 7 (4) : 335-345. https://doi.org/10.1007/s13668-018-0247-9 .

?