This is not an advice article

This is not an advice article

“Hi David. Thanks for everything you’re doing to increase healthy human lifespans. I’m excited by your research. Could you tell me what I should be taking?”

“Dr. Sinclair, what supplement should I be taking?”

“Dear David, I am not going to get any younger on my own. Would you please tell me how much NMN, NR, metformin or resveratrol I should be taking?”

I get messages like this every day, and often multiple times each day. And even though I’d like to, I simply don’t have the time to respond to all of them. Hence this short article.

First, though, a caveat. A big one. I DON’T GIVE ADVICE. Not on what chemicals you should put in your body, at least. If you’d like to know what restaurants to eat at in Boston, New York or Sydney, I might be your guy. But when it comes to how to live a longer and healthier life, I’m not going to tell you “do this” or “don’t do that.” I’m a researcher, not a medical doctor; I don’t make health and wellness recommendations.

I don’t mind sharing what I do, though, for whatever that is worth. In fact, in the spirit of transparency, I think it’s rather important. I try to do everything I can to make my life and my work an open book.

So, with all that in mind, strap in, because there’s a lot of stuff to go over.

OK, I’m just kidding. It’s actually quite simple:

? I take 750 mg of NMN every morning, along with a gram of resveratrol and 500 mg of metformin.

Yup, that’s it. There are other things that I am doing with an eye toward making it to 100, very healthy and happy, and continuing onward from there — maybe I’ll write about those things here in the future if there’s interest — but when it comes to the longevity molecules I’m putting in my body, that really is it.

And? So far so good.

My resting heart rate is 57 — I checked it again this morning. That, I'm told, is the heart rate of an athlete, and I'm no athlete. My lungs operate at levels doctors expect to see among adults in their 20s — quite a shock since I’ve inherited the genetic lung defect that contributed to my mother’s death. My LDL cholesterol and blood pressure are both considered very healthy for a young adult. When I exercise with weights, I recover quickly — just like I did when I was in my 20s. When I run I get bored long before I get tired.

What else would you like to know about my research and the fight against aging? Head on over to Twitter — you can follow me at @davidasinclair — and ask me a question.


Anne Han

Owner - Sales Manager

4 年

This is Sophia ,i just check your article,NMN is effect for us .It is popupalr in market at present.and we can provide it

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Thank you very much for publishing this account of what you take re: anti-aging. Could you let us know your suppliers, or reliable suppliers, although i cannot get metformin as i live in the UK and it needs a GP prescription. I am thinking of taking NR as well. Also if somehow you publicised this article maybe you would get less requests for information.

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Jurgen Van Puyenbroeck

Unit Manager bij Simac ICT Belgium

5 年

Hi,?has anyone of you experience with the quality of NMN made in China??

Dr. Sinclair, I really appreciate your research.? I started taking NMN and NAD+ a couple of weeks ago.? Based on the recommendation on the site where I purchased it, I have been breaking up the daily dosage of about 1G into smaller amounts, sublingual. Do you have any opinion on the value of sublingual vs. oral in terms of NMN?

Joseph Quispe

Molecular Biologist @ Regeneron | Mental Health Entrepreneurship | Mental Health business mentor | Juntos ERG member for Hispanic career advancement | RISE ERG member for Mental health advocacy

6 年

Where do you get a gram of?resveratrol a day? 500 mgs of pure?resveratrol?is like 300 bucks!

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