The Advantages of RI Detection in HPLC: A Comprehensive Overview

How Does RI Detection Work?

Refractive Index (RI) detection measures changes in the refractive index of the mobile phase as analytes elute from the column. This change in refractive index is directly proportional to the concentration of the analyte in the mobile phase.

Key Advantages of RI Detection:

• Universal Detection: RI detectors can detect almost any compound, making them ideal for analyzing non-UV-absorbing or weakly UV-absorbing substances.
• High Sensitivity: RI detectors can achieve high sensitivity, particularly for high-molecular-weight compounds.
• Quantitative Analysis: Accurate and precise quantitative analysis is possible with RI detection.

Applications of RI Detection in the Pharmaceutical Industry:

• Analysis of Sugars and Carbohydrates: RI detection is widely used for the analysis of sugars and carbohydrates, which often lack chromophores.
• Polymer Analysis: RI detection is valuable for analyzing polymers and other high-molecular-weight compounds.
• Chiral Separations: RI detection can be used to monitor chiral separations, especially when other detection methods are not suitable.

Synergy Health Utrecht: Your Partner in HPLC-RI Analysis

At Synergy Health Utrecht, we offer expert HPLC-RI services to support your pharmaceutical research and development needs. Our experienced team can help you with:

• Method development and optimization
• Validation of analytical methods
• Routine analysis and Quality Control
• Troubleshooting and problem-solving

By leveraging the power of RI detection, we can provide you with accurate and reliable analytical data to ensure the quality and safety of your pharmaceutical products.

Contact us today to learn more about how our HPLC-RI services can benefit your organization.

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