In addition to cervical cancer, infection with human papillomavirus HPV can also cause this disease

2020-10-23 huixin.D Shanghai CDC

In recent years, with the frequent appearance of keywords such as "cervical cancer" and "HPV vaccine" in the public eye, more and more people have begun to pay attention to the problem of human papillomavirus (HPV) infection.

In fact, HPV virus can cause other diseases besides cervical cancer and other malignant tumors.

Today,Shanghai CDC will introduce one of them - condyloma acuminatum.

There are more than 200 subtypes of HPV, and condyloma acuminatum is mostly caused by HPV6 and HPV11, which can lead to verrucous proliferative lesions on the skin and mucous membranes. Sexual transmission is the main route of transmission, and a small number of people can be infected through non-sexual transmission routes such as close contact. Pregnant women with condyloma acuminatum can also infect their newborns during childbirth.

The incubation period after infection with HPV is 1-8 months, with an average of 3 months.

What are the symptoms of condyloma acuminatum?

The location of the disease is in the genital and perianal areas. In the early stage of the disease, small papules (pinhead to mung bean size) appear locally, which gradually increase or increase, and develop into papillary, cockscomb, cauliflower-like or lump-like vegetations with uneven surface.

Patients are generally asymptomatic, and a small number of patients may have itching, foreign body sensation, pressure or burning sensation. Because condyloma acuminatum is prone to recurring attacks and affects daily life, it is easy to cause psychological burden on patients.

It is worth noting that the above-mentioned typical clinical manifestations are actually only the "tip of the iceberg" of condyloma acuminatum. HPV infection is mostly subclinical infection or latent infection, but it is still contagious. Subclinical infections do not produce visible skin lesions.

Will I get genital warts if I get HPV?

uncertain!

After the human body is infected with HPV, most infected people can clear the virus through their own immune system and will not develop condyloma acuminatum or other symptoms of infection, but they can still transmit the virus to others.

Can condyloma acuminatum be treated?

can be treated.

There are various treatment methods such as external medicine, laser, freezing, etc., and the doctor will choose according to the specific condition. Due to the high recurrence rate of condyloma acuminatum, patients should be followed up regularly for reexamination.

How to prevent condyloma acuminatum?

1. Vaccine prevention:

At present, the quadrivalent and ninevalent HPV vaccines can prevent about 90% of condyloma acuminatum, and can prevent about 70% and 90% of cervical cancer and related precancerous lesions, respectively. Studies in countries such as the United States and Australia have found that after the approval of the HPV vaccine, the prevalence of condyloma acuminatum in sexually active populations has dropped significantly.

2. Cut off the transmission route:

Since condyloma acuminatum is a sexually transmitted disease, maintaining a healthy lifestyle, using condoms correctly, etc. can reduce the risk of sexually transmitted diseases such as condyloma acuminatum. If you have suspected symptoms, you must go to a regular hospital for examination and treatment as soon as possible.

Original source:

[1] Zhao Fangqing, Zheng Shuyun. Research progress on the correlation between condyloma acuminatum and human papillomavirus infection [J]. Medical Review, 2018, 24(7): 1374-1377, 1382.

[2] Venereology Group of Dermatology Branch of Chinese Medical Association, Venereal Disease Sub-Committee of Dermatology Branch of Chinese Medical Doctor Association. Guidelines for the diagnosis and treatment of condyloma acuminatum (2014) [J]. Chinese Journal of Dermatology, 2014, 47(8): 598- 5

[3] Zhao Chao, Wang Jianliu. Selection of human papillomavirus vaccine for cervical cancer prevention and evaluation of preventive effect [J]. Chinese Journal of Clinicians, 2019, 47(9): 1036-1038.

[4] Xu Jinhua. Recurrence and prevention of condyloma acuminatum [J]. Chinese Journal of Dermatology, 2015, (5): 297-300.

[5] Weinstock, H., Schwartz, R., Flagg, E.W.. Prevalence of anogenital warts among participants in private health plans in the UnitedStates, 2003-2010: Potential impact of human papillomavirus vaccination[J]. American journal of public health, 2013 , 103(8): 1428-1435.

[6] Liu, B., Donovan, B., Brotherton, J.M.L., et al.Genital warts and chlamydia in Australian women: Comparison of nationalpopulation-based surveys in 2001 and 2011[J].Sexually TransmittedInfections, 2014, 90(7 ): 532-537.

Author: Shanghai CDC

The Human Papillomavirus Real Time PCR Kit is an in-vitro diagnostic (IVD) kit, based on real-time PCR technology, for the detection of 18 HPV types (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68, 73, 53, 82, and 26) in cervical exfoliated cells in one reaction well. The kit identifies HPV16, HPV18, other HPV types and internal control (β-globin) using fluorescence channels: FAM, VIC, ROX and CY5. This kit contains primers and probes that are designed to target the L1, L2, and E1 genes of 18 HPV types. The amplicon length of each HPV type does not exceed 200 bp. A PCR fluorescence detection system is used to record the change in fluorescence emitted by the fluorescent probe at each PCR cycle during PCR amplification, which directly reflects the change in the PCR amplification yield.