#92: ???? Can Hyperbaric Oxygen Therapy Be the Key to Cellular Rejuvenation?
New research suggests HBOT may reverse hallmarks of aging at the cellular level.
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Hey Friends,
I attended the BrainMind Summit in NYC which was a special forum on neuromodulation and brain computer interface.?
The most interesting thing I learned was that we have had brain computer interfaces (BCI) for 20 years!?
I thought Neuralink was the first one to implant a chip in a human!
….and I was wrong.
There is an organization called BrainGate which has been working on this science for two decades.?
They started the first BCI clinical trial in 2004. Patients were controlling a computer cursor with their mind by 2006.?
In Nina’s Notes #77, I mentioned that Neuralink was tracking cursor clicks with their first patient.?
I had thought this was very cutting edge, and now I see that they are repeating what has already been proven.
Stay tuned for an upcoming Nina’s Notes edition where I dive into the history of brain computer interface.
?? In this note:
???? What Are The Benefits Of A Hyperbaric Chamber For Healthspan??
This is a reader-requested question from Francisco. Thanks Francisco for the question!
A hyperbaric chamber is a pressurized tube or room that delivers 100% pure oxygen to patients at a level that's two to three times higher than normal air pressure.
The increased air pressure can improve the way your body takes up oxygen.?
This can help manage various conditions, including carbon monoxide poisoning, chronic wounds, and more.
How does it work?
When you breathe oxygen at normal atmospheric pressure, this gas is transported on hemoglobin in the red blood cells.
Under pressure, oxygen molecules decrease in size and are able to dissolve and saturate the plasma, cerebrospinal fluid, lymphatic fluid and other body fluids.
Higher oxygen absorption means more energy delivery to cells for accelerated cell repair and enhanced regeneration of tissue.
Hypoxic (low oxygen levels) tissue can lead to cell death. Hypoxia seems to play an important role in inflammation and aging.
Low tissue oxygen is associated with many? life threatening diseases such as stroke and heart attacks, diabetes, and cancer.
Anti-aging and HBOT (Hyperbaric Oxygen Therapy)
In 2020, a study from Tel Aviv University and Shamir Medical Center in Israel found that a unique protocol of treatments with high-pressure oxygen in a pressure chamber can reverse two hallmarks of aging.
There are 9 hallmarks of aging:
And the two that can be reversed through hyperbaric oxygen treatments (HBOT) are:
1. Telomere attrition
2. Cellular senescence
Telomeres are the protective book ends that protect the ends of our chromosomes from deterioration.?
As we age, the telomeres decrease in length.
When telomeres become too short, the DNA can no longer be replicated properly. This can then lead to the cell becoming senescent.
Senescent cells are cells in our body that are still alive, but have lost their primary functions.?
These senescent cells can accumulate in our bodies leading to a population of old and malfunctioning cells in the body, which is linked to aging.
The researchers have investigated hyperbaric therapy treatments based on protocols of exposure to high-pressure oxygen at various concentrations inside a pressure chamber.
Through their research, they have found improvements of brain function deterioration caused by age, stroke or brain injury.
A study published on Aging in 2020, looked at the anti-aging effects of HBOT on 35 healthy individuals aged 64 or over, who underwent 60 hyperbaric sessions over 90 days.
Each participant provided blood samples before, during and after the treatments. Blood samples were also taken 1-2 weeks after the series of treatments concluded.
The findings indicated the HBOT reversed the aging process.
The telomeres at the ends of the chromosomes grew longer instead of shorter, at a rate of 20%-40% for the different cell types.
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And the percentage of senescent cells in the overall cell population was reduced significantly.
In 2020, telomere shortening was considered the “Holy Grail” of biological aging.
Researchers around the world are trying to develop pharmacological and environmental interventions that will enable telomere elongation.?
The HBOT protocol was able to achieve telomere lengthening, proving that this aging process can be reversed at the cellular-molecular level.
It is also possible to inhibit telomere shortening through lifestyle modifications and intense exercise.?
The study revealed telomere elongation occurred within just 3 months.?
This growth rate surpasses the capabilities of all current interventions and lifestyle modifications.
Furthermore, HBOT has been shown to promote healthier aging biology, such as:
What does an HBOT session feel like?
The typical treatment lasts 60-90 minutes, during which time one relaxes in the pressurized chamber and breathes normally.
HBOT is described as safe and painless.
You may listen to music, watch a movie or just rest.
One experiences a feeling similar to flying in a plane or diving.
Air pressure must be equalized in the ears during the 15 minute compression and decompression phases by either swallowing or yawning.
Where can I find HBOT??
Due to these promising results, HBOT is becoming mainstream.
It is likely that you will be able to find a center offering HBOT in nearly any major city in the U.S. and Europe.?
?? Book of the Week
Rating: ★★★★★
Wow.
This book was gifted to me by my previous podcast guest, Hélène Guillame.
She had highlighted one of the most powerful quotes at the end of the book,
“But sufficiently provoked, there is hardly a creature on God’s earth that ultimately won’t turn and attempt to fight, regardless of the odds”
This is a story about a crew of Antarctic explorers who took on the impossible challenge of crossing Antarctica by foot.
Lead by Ernest Shackleton, one of the greatest explorer-leaders of history.
Quickly the crew experiences trouble. Their ship, the Endurance, gets beset (aka stuck) in an ice floe.
For months the ship simply floats along, as if one with the ice.
Until one day, the crew hears the first crunch. The Endurance survives, but weeks later, they hear the next crunch.
The ship’s hull starts to bend at the pressure.
And Shackleton gives the order – abandon ship.
The crew evacuates the ship to the safety of the large, ever shifting, pieces of ice afloat in the treacherous Weddell Sea.
Under the guidance of Shackleton, they manage to stay alive while adrift in the Weddell Sea, which eternally swirls in a clockwise fashion, churning icebergs and ice into each other, for nearly two years.
With no hope of a rescue vessel reaching them, as they are locked in between ice to the east and Antarctic land to the west over 100 miles away and completely out of reach, the crew assembled one camp after another. Hopping from floe to floe as some are broken up by the increased pressure.
Eventually forced into lifeboats they managed to rescue from the Endurance, the crew made it to Elephant Island.
With the conditions too terrible on this island to consider waiting for help, Shackleton embarks on the most dangerous journey ever taken.
He takes a small, open, 22-foot long lifeboat across the Drake Passage heading for South Georgia Island, the same island the Endurance launched from in 1914.?
The only other crew to attempt crossing the Drake Passage was in 1954, with a large research vessel stocked with plenty of supplies and a well and able crew.
Not a skeleton crew that had just survived 1.5 years afloat ice in the Weddell sea.
A truly remarkable story of commitment to keep his crew alive, and “an angry determination to see the journey through – no matter what.”
It’s a must read
?? Check This Out
A book of beautiful biology illustrations by German Biologist Ernst Haeckel.
The book, Kunstformen der Natur (Art Forms in Nature) was originally published in sets of 10 between 1899 and 1904.
The collection consists of 100 prints of various organisms, many of which were first described by Haekel himself.
Over the course of his career, more than 1000 prints were produced based on Haeckel’s sketches and watercolors.
The best were chosen for Kunstformen der Natur.
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Edited by Wright Time Publishing
So interesting as always! 20% faster is huge!
Founder | Consulting | RE Advisor
7 个月Hi Nina Patrick, PhD ! You should check out Ousia Clinic, they have one of the few Hyberbaric Chambers in Lisbon and it’s right next to Funda??o Champalimaud????
Building Checkfirst (checkfirst.ai) | Spearheading transformation in the TIC(C) Sector with AI
7 个月Fascinating
4x Founder | CEO at Learnerbly | Recipient of Queen’s Award for Enterprise Promotion | Forbes Columnist | World Economic Forum YGL
7 个月Interesting stuff! I've heard about athletes using hyperbaric chambers for recovery. Never thought it could be an anti-aging thing too.