9 October 2023
BioTechniques
BioTechniques is an open access journal and online resource, dedicated to the life science research community.
News
Getting to the root of carrots’ color
Researchers have uncovered the three genes responsible for the orange color of carrots in a study of 600 carrot genomes.?
Who won the 2023 Nobel Prize in Physiology or Medicine?
The Nobel Prize for Physiology or Medicine has been awarded to Katalin Karikó (Szeged University, Hungary) and Drew Weissman (University of Pennsylvania, PA, USA) for their foundational work in mRNA vaccines, which enabled the rapid development of the COVID-19 vaccines. Their discovery of the importance of nucleoside base modification in the immune acceptance and subsequent translation of synthetic mRNA, opened the gateway for a series of dramatic developments in vaccinology.?
The Human Brain Project: 10 years of research development in neuroscience
The 10-year funding period for the Human Brain Project (HBP) may have come to an end, but what has been achieved in this time will continue to benefit the field.??
More compact CRISPR enzyme engineered
Researchers have modified the AsCas12f enzyme to enhance its gene-editing activities while maintaining its small size.
Dinosaur feathers have similar protein composition to bird feathers
In a study on dinosaur feathers, researchers find that fossilization can alter trace protein composition and structure and find similarities to bird feathers.?
Monitoring estradiol levels in sweat
Estradiol is the most potent form of estrogen. Now, researchers have developed a way to monitor estradiol levels by detecting it in sweat.
In Focus
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Surface plasmon resonance
Surface plasmon resonance (SPR) technology has become an essential tool for researchers in drug discovery, protein engineering and beyond. By monitoring the real-time shift in refractive index as two biomolecules bind, researchers can determine the binding kinetics and affinity of the interaction as well as the concentration of the analyte. Its label-free and real-time nature makes it an attractive method for researchers looking to study the interactions between biomolecules, such as proteins, DNA and small molecules.
In this In Focus, in association with Sartorius, we provide an overview of how SPR works, how it compares to other popular techniques for measuring biomolecular interactions and how you can use SPR to further your research. Check out our animated video, infographic, podcast and eBook for all you need to know about SPR.
Interviews
Keeping it SIMPL: investigating protein–protein interactions with Igor Stagljar
In this interview, we discuss why targeting disease-associated PPIs is an attractive option for drug discovery and development, what technologies Igor Stagljar and his lab have developed and where PPI research is headed in the future.
Podcasts
STEM Tea | Season 1 roundup
In this bitesize episode, STEM Tea host Antentor "A.J." Hinton, Jr., Ph.D. looks back at the first season of the STEM Tea podcast, featuring many guests who’ve shared their perspectives and experiences on a variety of topics including mentoring, faith in science and improving DEI initiatives in schools.
Hello PhD | How to give a perfect poster presentation
Daniel Arneman and Joshua Hall discuss the value of a poster presentation and share their advice on tackling a poster session, taking you from planning your poster right through to presenting it at a conference.
Spotlight
Measuring biomolecular interactions
This Spotlight will explore:
- Techniques and technologies used to measure biomolecular interactions
- The role that protein–protein interactions play in drug discovery
- Computational tools for predicting biomolecular interactions
- Sartorius’ SPR and BLI platforms
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