27 March 2023
BioTechniques
BioTechniques is an open access journal and online resource, dedicated to the life science research community.
News
Bacteria release chemokines into tumors to stimulate a stronger immune response.
Pancratistatin, a cancer-fighting compound found in the Hawaiian spider lily,?selectively?targets cancer cells.?
Opinion
Research?suggests that some of the most common reasons for publication retraction are concerns or issues with data and duplication, which could be caused by inaccurate or manipulated images.?Here, Dror Kolodkin-Gal, co-founder of the automated image integrity detection software?Proofig, explains why researchers should focus on image integrity in a similar way to plagiarism checks.
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Antibody discovery is a crucial first step in developing antibody therapeutics. Large numbers of antibodies are screened and assessed for their therapeutic potential; these programs rely on high-throughput technologies to quickly identify candidates. Discovery workflows begin with identifying thousands of antibodies against a specific target and then triaging them through a series of?in vitro?binding and functional assays to identify the top leads.
For our Spotlight on antibody discovery, we are conducting a survey of the community to find out the latest trends and behaviors in the field. Tell us all about the focus of your research, the techniques you use, the biggest challenges in discovery and your thoughts on the latest developments in the field.
The survey takes under 10 minutes to complete, and all survey respondents will be automatically entered into a prize draw to win a US$50 Amazon gift card or donation to a charity of your choice.
The past decade has seen an explosion in the number of antibody-based therapeutics on the market. A huge driver of this has been the advancement of technologies that improve the time and efficiency of antibody discovery. Robust, high-throughput techniques for screening antibody libraries have led to better quality hits in less time. Moreover, combining several?in vitro?methods to assess a broad range of antibody parameters, for example target binding and Fc function characteristics, builds a full profile of a candidate molecule and informs preclinical studies.