27 January 2025
BioTechniques
BioTechniques is an open access journal and online resource, dedicated to the life science research community.
News
Adapt to survive, thrive and colonize: exploring human colonization by?S. aureus
A new approach to the investigation of bacterial adaptations could help improve the prevention and treatment of bacterial infections.
Harnessing an extremophile’s bioactive compound for industrial applications
A bioactive compound produced by an extremophilic bacterium has potential industrial applications.
DNA and RNA methylation directly linked for the first time
DNA and RNA methylation, initially thought to operate as distinct pathways, have been shown to interact closely, shifting our understanding of gene regulation.
How is the integration of CRISPR and 3D culture systems advancing disease modeling and personalized medicine?
In this issue of BioTechniques, we present a colorimetric-based method for quantifying biotin binding capacity, the development of a portable device for RNA extraction and a protocol for assessing cell-line immortality.
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Interviews
Defying gravity: musculoskeletal aging models in space
What happens to our muscles on a cellular level as we age? Anne McArdle, Professor of Musculoskeletal Aging at the University of Liverpool, is fascinated by this question, dedicating her research to understanding how muscular systems become dysfunctional, specifically in aging. To investigate muscular aging in an accelerated capacity, Anne and her colleagues utilize a microgravity model, which involves sending muscle cells to the International Space Station.
At ELRIG Drug Discovery 2024 (2–3 October 2024), Anne presented some of her microgravitational muscle research, and we got a chance to catch up with her at the event to learn more about the benefits of microgravity models in muscle aging research as well as how these models can inform intervention development.
Dopaminylation: looking at Parkinson’s from a new angle
Winnie Chen is an MD PhD student in the lab of Ian Maze at Mount Sinai. Winnie’s current work is focused on understanding the role of dopamine in Parkinson’s disease. The lab is interested in the new idea that dopamine can act as a post-translational modification of proteins.
In this interview from the meeting of the Society for Neuroscience, Neuroscience 2024 (5–9 October), Winnie discusses a project that uses a novel chemical probe to investigate the dopaminylation of proteins, particularly histone H3, in Parkinson’s disease and aging.
In conversation: Michelle Itano on ASCB 2024 and the latest developments in immersion microscopy
In this interview feature, we catch up with our Editor-in-Chief, Michelle Itano (University of North Carolina at Chapel Hill) to discuss her recent experiences at the annual meeting of the American Society for Cell Biology (ASCB; 14–18 December 2024).
Read on for an insight into the key trends at the conference, the developments empowering the investigation of inter-organelle contacts and a handy new tool that could dramatically improve the practicality of immersion microscopy.
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