20 November 2023
BioTechniques
BioTechniques is an open access journal and online resource, dedicated to the life science research community.
News
Novel CRISPR-based screen identifies target for improved T-cell therapies
Using a new CRISPR-based methodology for modulating DNA structure to enact epigenetic control over specific genes, a team of researchers has identified a “master regulator” gene capable of improving T-cell therapies for treating cancer.
Predicting sgRNA efficiency with quantum biology and AI
Researchers advance understanding of single guide RNA (sgRNA) design to optimize CRISPR/Cas9 cutting efficiency using an explainable AI model.
Non-invasive diagnosis of Alzheimer’s disease from saliva samples
A non-invasive, handheld Alzheimer’s diagnostic test could be on the horizon.
Unraveling molecular signaling mysteries using synthetic enzymes
Researchers synthesize enzymes to learn more about a signaling protein involved in the development of muscle, bone and blood in vertebrate embryos.
Paralyzing cells could prevent metastasis
A mechanism of dynein-powered metastatic locomotion has been identified using soft tissue models, revealing a new clinical target for breast cancer treatment.
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Researchers are one step closer to synthesizing a complete yeast genome
A yeast strain with 31% synthetic DNA has been successfully produced, displaying normal morphology and budding behavior.
Features
The 2023 John Maddox Prize winners: defending science in the face of corporate greed
The 2023 John Maddox prizes, which commemorate the former editor of Nature and paragon of good scientific communication by rewarding researchers who bravely stand up for sound science in the face of personal or public persecution, have been announced.
Liquid-electron microscopy: making waves in structural biology
Liquid-electron microscopy (EM) is an established advanced characterization method, although it has only recently been making waves in the field of structural biology. In this article, Samantha Berry, Liza-Anastasia DiCecco and Deborah Kelly from the?Kelly Lab?at Pennsylvania State University, and Jennifer Gray, an Associate Research Professor at the Material Research Institute of PSU, share their advice for novel users of liquid-EM, discussing sample preparation and imaging conditions.
Journal issue
What has spatial biology taught us about embryogenesis?
In this issue of BioTechniques, we present an image analysis workflow to analyze geometrical and texture features of all types of mesenchymal stem cells, a simple colorimetric assay for Pseudomonas aeruginosa detection, and a cost-effective method for isolating high quantities of RNA from various kenaf tissues.
Webinar
Panel Discussion: Measuring protein–protein interactions
In this Panel Discussion, join experts in biomolecular interaction research as they explore the importance of investigating PPIs in disease, considerations for selecting the best technique for your goals, limitations and solutions of these techniques and the future of PPI research.?
When: Thursday 7 December 2023 | 07:00 [PST] 10:00 [EST] 15:00 [GMT]
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