Zifo Bioinformatics的动态

In the last five years, clear evidence has shown that both DNA and RNA form left-handed double helices and these molecules play a role in biology (and may provide a new way to fight cancer) - read the fascinating story of Z-nucleic acids https://lnkd.in/eZsp5zDB #nucleicacid #immuneresponse #cancerbiology #genomicresearch

Exploring the World of Single-Cell Analysis ?? In the realm of bioinformatics and genomics, single-cell analysis is a game-changer. Unlike bulk studies that provide an average view, single-cell analysis dives into the individuality of each cell, uncovering unique insights into biological complexity. ?? What is Single-Cell Analysis? It’s the study of individual cells to understand their unique genetic, transcriptomic, proteomic, or epigenomic profiles. By focusing on one cell at a time, we can explore cellular heterogeneity and discover nuances that bulk analyses miss. ?? Why It’s Important: ?? Identifies rare cell types in a population. ?? Maps cellular differentiation pathways. ?? Uncovers mechanisms in diseases like cancer. ?? Provides insights into immune responses and tissue regeneration. ?? Applications: Cancer Research: Understand tumor microenvironments and cell mutations. Immunology: Study immune cell diversity and responses. Developmental Biology: Map the fate of individual cells during growth. ?? Single-cell analysis is more than just a method—it’s a revolution in how we perceive biology at its most fundamental level. #CodeBio #Bioinformatics #SingleCellAnalysis #Genomics #PrecisionMedicine #CellBiology

Core Oxford Nanopore Technologies webinar: Scalable human genomic characterisation with nanopore sequencing. This webinar will take place at 4pm (BST) or 11:00am EDT Our speakers will cover:? The technical fundamentals of implementing nanopore sequencing and the bioinformatic analysis workflows needed for your research. The level of accuracy nanopore sequencing offers for the detection of genomic variations to deliver comprehensive insights. The usage of pre-packed bioinformatic workflows to run data analysis and retrieve key genomic information. Examples used in research settings to investigate genetic disorders, cancer genomics, or population genetics. Register Here https://lnkd.in/daUYNGyX

Hortman Stem Cell Laboratory is proud to be the first stem cell genomics laboratory in the region, offering both advanced stem cell banking and state-of-the-art molecular and genomics testing. With a vision to lead in molecular diagnostics and genomics, our facility provides a wide range of services, including Non-Invasive Prenatal Testing (NIPT), HLA typing, metagenomics, Preimplantation Genetic Screening (PGS), and consumer genomics. Our cutting-edge technology, powered by platforms such as Next-Generation Sequencing (NGS), real-time PCR, and Sanger sequencing, enables us to set new standards for precision and innovation in healthcare. #HortmanStemCellLaboratory #Genomics #StemCellBanking #MolecularDiagnostics #NGS #PrenatalTesting #HLATyping #ConsumerGenomics #HealthcareInnovation #PrecisionMedicine #DubaiHelath #BiomedicalResearch #GenomicsTesting #LabExcellence

The Target ALS Data Engine just got bigger. We've expanded datasets across all core collections, including new whole genome sequencing, RNA sequencing, spatial transcriptomics data, longitudinal speech data, stem cell lines, and more. To enhance your experience, we've also introduced a comprehensive user manual and new demo videos for each collection. These additions are designed to help researchers navigate the platform with ease and fully utilize the rich datasets available. By providing these new tools, we aim to empower scientists to accelerate ALS research, drive breakthroughs in biomarker discovery, and advance the development of effective therapies. Read more: https://bit.ly/47bo1eN Explore the latest updates and take your research further: https://bit.ly/4cTg6nD #ALSResearch #DataEngine #TargetALS #ResearchImpact #EveryoneLives

?? Achievement Unlocked: Mastering CRISPR/Cas9 Genome Editing with Linux! ???? ?? ?? I’m thrilled to share that I’ve successfully completed a hands-on workshop on CRISPR/Cas9 Analysis from Dr. Omics Labs in New Delhi! This training equipped me with cutting-edge tools to edit genomic sequences using Linux, specifically focusing on BRCA1 mutations in breast cancer research. ?? Case Study Highlight: ?? Breast cancer is often linked to mutations in the BRCA1 gene, increasing cancer risk. During the workshop, I focused on dealing with genomic data and interpreting the results related to these mutations, enhancing the understanding of targeted therapies. This critical step paves the way for innovative approaches in cancer treatment. ?? This workshop also complements my experience in Next-Generation Sequencing (NGS) data analysis, which I gained during another workshop held at CRBt, Constantine using the Galaxy platform. Together, these experiences have strengthened my expertise in gene editing and computational biology! ?? Let’s connect and collaborate in the fields of: #NGS #Linux #GeneEditing #ComputationalBiology #CancerResearch #BRCA1 #CRISPR #GenomeEditing #Bioinformatics #Postdoc

? Insights into X-PAND scientific impact X-PAND aims to develop a toolbox of innovative #geneticengineering technologies applied to hematopoietic stem cells (HSC). X-PAND’s concepts and tools will catalyses fundamental research, offering key insights into: ??? HSC Biology: optimization of the HSC platform and the study of clonal HSC dynamics will provide crucial insights into their biology. ?? DNA Repair: exploring editing technologies and analysing patient cells with DNA repair gene mutations will inform cell biology questions about DNA Damage Response. ?? X-PAND is committed to openness: the bioinformatic tools developed will be shared with the wider scientific community, extending the project's impact beyond its immediate scope. ?? Learn more about the X-PAND project here www.xpand-project.eu #EIC #genetherapy #celltherapy?

Cancer Research| Cancer Research Project for Biotech & Bioinformatics| Bioinformatics Tools & Skills for Cancer Research #cancer #cancerresearch #cancerbiology #bioinformatics #bioinformatics #drjyotibala #molelixirinformatics #molecularbiology #research Hey there, bioinformatics and biotech enthusiasts! Welcome to our engaging video featuring 7 beginner-friendly bioinformatics cancer research projects. If you're excited to combine your passion for cancer biology with data analysis, you've come to the right place. In this video, we walk you through each project's overview, benefits, applications, significance, and provide a step-by-step approach to tackle them. https://lnkd.in/gmbca5hN

Although I have strong doubts about the use of genAI, I have very much enjoyed collaborating on this AI/Machine learning-based project headed by Marc Pages-Gallego from the Jeroen de Ridder group at the Center for Molecular Medicine, Cancer Research UMC Utrecht. Mutations in the DNA are the drivers of #cancer and #aging. These mutations can be the result of DNA-base oxidation, especially on Guanine (resulting in 8-oxo-dG). But it has been very challenging to reliably quantify and localize 8-oxodG in the genome and correlate these to mutations. Marc used #Nanopore technology to sequence repeats of synthetic DNA containing 8-oxo-dG in variable contexts, to train a neural network to distinguish 8-oxo-dG from unmodified G. The low abundance of 8-oxo-dG required an extremely stringent false-discovery rate, but in the end Marc got it to work and we were able to correlate 8-oxo-dG to C>A mutations as well as to 5-methyl-cytosine levels in the genome of a human tissue culture model for oxidative DNA damage created by Daan van Soest. Manuscript now on Biorxiv!