WashU Pathology & Immunology的动态

I'm thrilled to announce that my first PhD work research article has just been published in Molecular Medicine! ?? In this study, we showed for the first time, that GAGs from patients with Sanfilippo syndrome (mucopolysaccharidosis type III, MPS III) can induce microglial secretion of EVs that deliver a specific molecular message to recipient naive neurons, while promoting the neuroinflammation, and depriving neurons of neurodevelopmental factors. Moreover these EVs alter the morphology of the neuronal somatodendritic compartment with a disease-associated signature. These results strongly suggest that EVs secreted by MPS III microglia participate to the progression of the neuropathology.

New publication (preprint), jointly published by: a) Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Czech Republic. b) Czech Institute of Advanced Technology and Research, Institute of Molecular and Translational Medicine, Palacky University of Olomouc, Czech Republic and c) Institute of Immunology "Nicolas Enrique Bianco". Faculty of Medicine. Central University of Venezuela. Caracas. Venezuela. Article title: Exploring How Adipose Tissue, Obesity,and Gender Influence the ImmuneResponse to Vaccines: A Comprehensive Narrative Review. Authors: Juan Bautista De Sanctis, Germán Balda Noria and Alexis Hipólito García.

Elizabeth Vinod?and her colleagues discovered promising results for their present study on the ghrelin hormone secretagogue receptor and membrane-bound ghrelin O-acyl transferase as possible markers for chondrogenesis in human articular cartilage-derived cells. #cartilagerepair #chondrogenesis #celltherapy #Chondroprogenitors Department Of Bio-Technology (Dbt), Christian Medical College Vellore, Institute for Stem Cell Science and Regenerative Medicine (BRIC-inStem) Congratulations?team members:?Ganesh Parasuraman, Abel Livingston, Grace Rebekah and Solomon Sathishkumar Read the full article: Exploring Ghrelin Hormone Secretagogue Receptor and Membrane-Bound Ghrelin O-Acyl Transferase as Potential Markers for Chondrogenesis in Human Articular Cartilage-Derived Cells. European Journal of Anatomy. Nov 2024?https://lnkd.in/gtwSMEky.

Our special issue “molecular mechanisms of aging on hetatopoiesis” is online!

?? Our Special Issue on hematopoietic stem cell ageing is now online!??? bit.ly/3CHC2G1 ?? Seven reviews highlight mechanisms, pathways, and key factors involved in HSC ageing and age-related pathologies. ???? Guest edited by Eleni Katsantoni, Biomedical Research Foundation of the Academy of Athens.

New publication (preprint), jointly published by: a) Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Czech Republic. b) Czech Institute of Advanced Technology and Research, Institute of Molecular and Translational Medicine, Palacky University of Olomouc, Czech Republic and c) Institute of Immunology "Nicolas Enrique Bianco". Faculty of Medicine. Central University of Venezuela.Caracas. Venezuela Article title: Exploring How Adipose Tissue, Obesity,and Gender Influence the ImmuneResponse to Vaccines: AComprehensive Narrative Review. Authors: Juan Bautista De Sanctis, Germán Balda Noria and Alexis Hipólito García.

Frontiers in Bioscience-Landmark Call for papers for Special Issues?? #CallForPapers "#Molecular Basis of Immune Regulation in Autoimmunity"?? ?? Submission deadline: 30 April 2025 ???? Guest editor: Dr. Margherita Sisto, sabrina lisi , Department of Translational Biomedicine and Neuroscience (DiBraiN), Section of Human Anatomy and Histology, Università degli Studi di Bari, Bari, Italy We invite submissions exploring the intricate mechanisms underlying immune dysregulation in autoimmune disorders. Researchers are encouraged to contribute original research articles, #reviews, and perspectives shedding light on molecular pathways, immune cell interactions, and therapeutic interventions. Submissions welcome from experts in immunology, molecular biology, and related fields. For submission guidelines and inquiries ?? https://lnkd.in/gxuy8Czi #OpenAccess #Bioscience #biomedicalscience #biochem #medicalscience #ScienceCommunication #Biochemistry #StemCell #Virology #CancerResearch #immunology; #Genetics #MolecularBiology #Microbiology #medicine #health

Exciting breakthrough alert! Researchers at the University of Bristol and collaborators have identified a groundbreaking treatment for age-related macular degeneration (AMD), the leading cause of vision loss in older adults. Their discovery of boosting a protein called IRAK-M shows promise in protecting against retinal degeneration. This innovative approach offers new hope for the millions suffering from AMD. Learn more about this game-changing research in Science Translational Medicine and how it could transform AMD treatment. #AMD #visionresearch #innovation

Exciting News for Our Institute!? I am proud to announce that Prof. Dr. Igor G. Bondarenko, Senior Researcher at the Medical Institute for Nutrition Science and Technology, has co-authored a groundbreaking article that has been published in the prestigious?Journal of Orthomolecular Medicine. ?? The article, titled?“Targeting the Mitochondrial Stem Cell Connection in Cancer Treatment: A Hybrid Orthomolecular Protocol,”?is a collaborative effort with international experts and marks a significant milestone in our ongoing research at the institute. This publication not only highlights the innovative work being done in orthomolecular medicine but also strengthens our position in the global scientific community. ?? We are incredibly proud of Prof. Dr. Bondarenko and his contribution to this important field of study. This success reflects our commitment to advancing medical research and pushing the boundaries of what’s possible. You can read more about this achievement and access the full article here: https://lnkd.in/gP5PRDgn #research #orthomolecularmedicine #cancerresearch #publication #teamwork #innovation #medicalscience #proudmoment

New #diabetes research published in Stem Cell Reports: Microvessel co-transplantation improves poor remuscularization by hiPSC-cardiomyocytes in a complex disease model of myocardial infarction and type 2 diabetes #T2D #cardiomyopathy #cardiomyocytes #regeneration Institute of Biomedical Engineering | UofT Department of Laboratory Medicine & Pathobiology | University Health Network | University of Toronto | Cell Press | Gairdner Foundation | SickKids Foundation https://ow.ly/S5wa50UM43F