Vizgen的动态

?? Unraveling Tumor Microenvironments with DeMixT ?? Understanding tumor-stroma interactions is crucial for cancer research, and DeMixT is here to help. Developed by MD Anderson Cancer Center, this tool deconvolutes transcriptomic data to reveal critical insights. ?? Why Choose DeMixT? Precision Deconvolution ?? Separate tumor, stroma, and immune components for accurate expression profiling. Gene-Specific Insights ?? Gain expression data at the gene level for each microenvironment component. Flexible Use Cases ?? Apply DeMixT to a variety of cancer types and datasets. Decode the tumor microenvironment with confidence using DeMixT. ?? Enhance your cancer research today! #CancerBiology #Bioinformatics #Microenvironment #Transcriptomics

The Collaborative Centre for Genomic Cancer Medicine is driving innovation in technology and developing new ways to improve cancer diagnosis and screening – including tests that can detect tumours with a single drop of blood. Sarah-Jane Dawson's Molecular Biomarkers and Translational Genomics Lab is pioneering alternative ways to collect tumour information from a simple blood test, by deciphering small amounts of cancer-derived DNA in the bloodstream. ?? Learn more: https://lnkd.in/gNxVJ5C7

How do cancer cells adapt to their environment? #TAMUbme's Dr. Tanmay Lele and his team recently published their article in the highly prestigious PNAS journal revealing that genetic variation in cancer cells drives adaptation to different extracellular matrix (ECM) stiffness levels. Researchers found that these cancer cells grow faster and spread in soft ECM environments —shedding light on how ECM stiffness, a key property of the changing tumor microenvironment, can exert natural selection in genetically variable tumor cells. This insight is vital for understanding tumor evolution, which plays a key role in cancer spread and the development of drug resistance! Dive deeper into their research at https://lnkd.in/gSGEeNXX

Did we just find a “kill switch” for #cancer? According to a recent reel from BBC, Scientists hypothesised a kill switch to Cancer in space. The cancer tumour triples in size in 10 days in space while it would take a decade on Earth. The reason behind it is the microgravity. Dr. Catriona Jamieson, Hematologist, UC San Diego School of Medicine underscores the significance of this finding by noting that if cancer can proliferate rapidly in space, it opens the door for equally rapid experimentation by scientists. Taking advantage of this phenomenon, the team at UC San Diego tested a new experimental #drug named #Rebecsinib. This drug targets the ADAR1 gene, also known as the cancer cloning gene, aiming to deactivate or genetically suppress it. Preliminary tests conducted during the space mission indicate that #Rebecsinib may indeed act as a promising "kill switch" for cancer. To know more on the experiment, explore here:?https://lnkd.in/drYtRZWY. Dr. Catriona also highlights another intriguing aspect: “Microgravity is like a rocket fuel for aging stem cells”. #Source:?https://lnkd.in/dU3GJAaR Curious about how #microgravity can revolutionise #cancerresearch? Please feel free to reach out to us. Will be back soon with more updates on #Space & #pharma!

Scientists at KAIST, led by Prof. Kwang-Hyun Cho, have created a groundbreaking therapy that reprograms colon cancer cells to behave like healthy cells rather than destroying them. This innovative approach uses advanced gene modeling to target molecular switches, offering a safer and more effective treatment with minimal damage to healthy tissue. Unlike traditional therapies that focus on killing cancer cells, this new method changes the cancer cells at the molecular level, essentially reversing their harmful behavior. The research, published in Advanced Science, marks a significant step forward in cancer treatment, providing hope for less invasive and more targeted therapies in the future. This breakthrough could lead to more effective cancer treatments with fewer side effects. #cancerresearch #cancer #researchanddevelopmemt #ogelpublications

?? Understand Somatic Mutations with FASMIC ?? Not all mutations are created equal—FASMIC, from MD Anderson Cancer Center, helps annotate their functional impacts to guide cancer research. ?? Why Researchers Trust FASMIC Somatic Mutation Insights ?? Understand how specific mutations affect cancer biology. Streamlined Annotation ?? Integrates multiple genomic datasets for a comprehensive analysis. Actionable Results ?? Gain insights that guide therapeutic targets and biomarker discovery. Decode the functional impacts of somatic mutations with FASMIC today. #CancerResearch #Mutations #Bioinformatics #PrecisionMedicine

?? Have a look at our latest study on targeting ubiquitin signalling in cancer In our latest study, we identified USP10 as a driver of oncogenic transformation in colorectal cancer by stabilizing β-Catenin in an APC-truncation-specific manner. Using in vivo and ex vivo CRISPR genome editing, organoid models, and advanced omics, we revealed a novel mechanism and discovered that targeting USP10 presents a therapeutic vulnerability. This was a multi-center effort involving labs from the The Francis Crick Institute Oncode Institute Universit?tsklinikum Würzburg Ludwig-Maximilians-Universit?t München Helmholtz Munich The Julius Maximilians University of Würzburg Technion - Israel Institute of Technology Amsterdam UMC Goethe-Universit?t Frankfurt a. Main Frankfurt ?? https://rdcu.be/dXO1C #CancerResearch #USP10 #CRISPR #Organoids #ColorectalCancer

?? The Curated Cancer Cell Atlas: comprehensive characterisation of tumours at single-cell resolution? ? Tyler et al. significantly extended the Curated Cancer Cell Atlas to 124 datasets for over 40 cancer types, together comprising 2,822 samples, with improved data annotations, visualisations and exploration.?? ? Key points? ? Systematic quantification of context-dependent gene expression and proliferation patterns across cell types and cancer types? ? A comprehensive quantification of cell cycle, revealing high variability in proliferation rates across cell types and cancer types? ? Uncovering biases in cell cycle phases that are associated with driver mutations, most notably TP53? ? Freely available here: https://lnkd.in/eiaRk7k6 ?? More details: https://lnkd.in/eYnC5jQ2 #weizmanninstituteofscience #weizmanninstitute #spatialomics #spatialbiology #singlecellanalysis #singlecell

?? A knowledgebase of cancer metastasis at bulk, single-cell and spatial levels? ? Wu et al. presented metsDB, comprehensive resource for understanding the metastasis process and for designing molecular therapies.? ? Key points? ??1786 bulk tissue samples from 13 cancer types, 988 463 single cells from 17 cancer types, and 40 252 spots from 45 spatial slides across 10 cancer types? ??Insights into alterations in cell constitutions, cell relationships, biological pathways, molecular biomarkers, and drug responses during cancer metastasis at bulk, single-cell, and spatial levels? ??Cell or gene searches to obtain multi-view and multi-scale metastasis-related data? ??Accessible at https://lnkd.in/d5J9TdxF ?? More details: https://lnkd.in/d3dkJEyY? #XidianUniversity #spatialomics #spatialbiology #singlecellanalysis #singlecell

Hi all! Back with another mind-blowing space and pharma story that will change how you see medical innovation! ? ? Did we just find a “kill switch” for #cancer?? ? According to a recent reel from BBC, Scientists hypothesised a kill switch to Cancer in space.? ? The cancer tumour triples in size in 10 days in space while it would take a decade on Earth. The reason behind it is the microgravity.? ? Dr. Catriona Jamieson, Hematologist, UC San Diego School of Medicine underscores the significance of this finding by noting that if cancer can proliferate rapidly in space, it opens the door for equally rapid experimentation by scientists.? ? Taking advantage of this phenomenon, the team at UC San Diego tested a new experimental #drug named #Rebecsinib. This drug targets the ADAR1 gene, also known as the cancer cloning gene, aiming to deactivate or genetically suppress it. Preliminary tests conducted during the space mission indicate that #Rebecsinib may indeed act as a promising "kill switch" for cancer.? ? To know more on the experiment, explore here: https://lnkd.in/drYtRZWY. ? ? Dr. Catriona also highlights another intriguing aspect: “Microgravity is like a rocket fuel for aging stem cells”.? ? Source: https://lnkd.in/dU3GJAaR? ? Curious to learn more? Drop your questions below or schedule a call: https://lnkd.in/ebUk8Bzn?? ? Stay tuned for another exciting update next week.?