UNC Lineberger Comprehensive Cancer Center的动态

Gerta Hoxhaj receives a 2024 Vilcek Prize for Creative Promise in Biomedical Science. An alum of Bo?azi?i University, Hoxhaj completed her PhD at the University of Dundee, before moving to the United States to pursue postdoctoral research work on cancer metabolism at Harvard University. Hoxhaj is an Associate Professor at the Children's Medical Center Research Institute at the UT Southwestern Medical Center. She receives the $50,000 prize for her work on mapping the molecular links between signaling pathways and metabolic networks of cancer cells. Her research focuses on identifying vulnerabilities in cancer metabolism that could be used to develop targeted therapies. #CancerResearch #CancerScience #WomeninScience #WomeninSTEM #VilcekPrize

Two Mayo Clinic graduate students from the same hometown share their journey to becoming Ph.D. researchers who study regenerative medicine and new approaches to treating cancer. Mexican pride: the journey of two young Mexican researchers to the elite, by Jose Arrieta. They say that dreams that are pursued with perseverance always come true, and two young researchers, originally from Juárez, can confirm this, because thanks to their efforts they stand out in a world-renowned institution. Claudia Martínez and Omar Gutiérrez saw their dreams come true when they were integrated into the research team at the Mayo Clinic, known for its research in various medical specialties. “For my doctorate, I wanted my education to be oriented toward immunotherapy and cancers, but to try to apply it as a more translational concept, so that what we develop in the laboratory has the potential to be used in a clinical trial. Mayo Clinic is one of the few institutions in the United States that has the funds, machinery and research departments to be able to finance clinical trials,” explains Martínez. Article: Orgullo mexicano: la travesía de dos jóvenes investigadores mexicanos a la élite | El Heraldo de México (https://bit.ly/4be8eNo)

We are pleased to highlight a new paper from Elham Azizi's lab, recently accepted in Genome Research. The study led by Cameron Park and Shouvik Mani presents DIISCO, an innovative method for studying dynamic cell-cell interactions using single-cell RNA sequencing data. DIISCO represents a significant advancement in understanding how cells communicate and evolve over time, particularly in the context of cancer and immune responses. By tracking these interactions longitudinally, the method offers new insights into treatment responses and cellular dynamics. Read more: https://bit.ly/4gLr9lJ #CancerResearch #SingleCellRNAseq #SingleCell #BiomedicalEngineering #Genomics #DIISCO Herbert and Florence Irving Institute for Cancer Dynamics , Columbia University Biomedical Engineering, Columbia University Department of Computer Science, The Data Science Institute at Columbia University, Columbia Engineering, Columbia University Irving Medical Center, Columbia University

Today is an exciting full circle day for me, which is about 10 years in the making. 10 years ago I was working in Dean A. Lee’s lab at MD Anderson Cancer Center as a graduate student. After my candidacy exam, I had the opportunity to analyze some patient samples for a Phase I study in patients receiving haplo identical HSCT with adjunctive adoptive NK cell therapy. It was the end of the summer and we were working with summer students. I volunteered to work with the next one because I had devoted most of my time earlier in the summer to preparing for my candidacy exam. This summer student happened to be the daughter of Stefan Ciurea. We began running the patient samples and analyzing the data and found some exciting results that were later published. That project began my interest and passion in clinical research. Fast forward to 2020, I was working for Kiadis as a Medical Science Liaison, supporting the very same NK cell therapy I had studied in graduate school. Kiadis needed some data quickly for an upcoming abstract submission. I was asked to go back to the lab and generate the data ?? Dean’s lab to be exact, now located at Nationwide Children's Hospital. To say I was nervous would have been an understatement. I spent a week at Dean’s lab running patient samples and analyzing data. It was one of my most stressful projects, knowing how limited and precious the patient samples were and how important the data was to the company. Not to mention it had been almost 3 years since I had worked in the lab. But, I look back on that week with a sense of pride. Even though I was scared, I had courage to do something challenging and different. And the best part was, we found some exciting data around NK cell persistence. That data was published today along with results from the trial! What a fun and unlikely story of clinical research and teamwork. Here is a link to the article https://lnkd.in/g2t_7ZYX Check out the picture below of my stint back in the lab. #celltherapy #NKCells #immunotherapy #clinicaltrials #cancerresearch #AML #clinicaldevelopment #GSBS #UTMDACC

Campus Plus is pleased to announce the commencement of an Australian Government Department of Education National Industry PhD Project, which brings together Flinders University and GNOMIX Pty Ltd. This collaborative effort brings together academic expertise with industry insights to drive innovation and create real-world impact. The project, titled "Development of novel circulating tumour DNA-based assays to improve treatment decision-making in prostate and breast cancer," aims to develop new non-invasive assays, based on measuring circulating tumour DNA in blood, that can identify alterations to genes with critical roles in these common cancers. By identifying such alterations, the assays will enable patient-specific prediction of response to therapy as well as real-time tumour profiling to guide treatment decision-making. In this collaboration, Associate Professor Luke Selth of Flinders University provides the expertise in prostate and breast cancer biology and how specific genomic alterations influence response to therapy,?while Scott Grist from GNOMIX brings expertise in genetic technologies and translation of research into clinically relevant assays. From GNOMIX’s perspective, this project holds exciting potential to transform outcomes for patients with prostate and breast cancer by enabling real-time tumour profiling. Identifying the emergence of resistance mutations in the tumour DNA earlier will help guide treatment decision-making, significantly improving treatment outcomes and the quality of life for these patients. Industry Researcher Rachel Hall is keen to commence the project stating: “I’m very grateful to have the opportunity to commence a PhD as an Industry Researcher through the National Industry PhD Program. This is a fantastic initiative that brings together industry and research and makes undertaking a PhD possible for industry professionals”. From the University’s perspective, this collaboration fosters high-quality research, which will advance the state of knowledge and demonstrate the tangible societal benefits their research provides. Thank you to Nilla Wen for facilitating this project. Round 5 of the National Industry PhD Program is scheduled to open in February 2025. For more information, please visiting the Campus Plus website: https://lnkd.in/gpVsGZZ6 #AEA #tumourprofiling #tumourDNA #industryuniversitycollaboration #researchanddevelopment #universities #industryPhd #PhDscholarships #prostatecancer #breastcancer?

???? Exploring Horizons: SIOPEN Translational Research Meeting in Vienna ?? Over the next 3?? days, scientists from leading institutions such as St. Anna CCRI, Charité - Universit?tsmedizin Berlin, Institut Curie , Prinses Máxima Centrum voor kinderoncologie, University of Leeds and the Vall d'Hebron University Hospital will engage in dynamic discussions on pivotal topics, spanning the realms of Liquid Biopsies, Tumor Biology, and New Drug Development. ?? The SIOPEN Translational Research Meeting in Vienna brings together visionaries and experts in the field, with the local Organizing Committee led by St. Anna Kinderkrebsforschung (Children's Cancer Research Institute - CCRI) researchers Sabine Taschner-Mandl, Kaan Boztug, Ruth Prof. Dr. Ladenstein, and Marie Bernkopf. Collaborating with the SIOPEN Translational Research Committees and the chairs and co-chairs of the Translational Research Speciality Committees and Working Groups, the event promises groundbreaking discussions and insights with the aim to develop better diagnostics and therapy options for children with #neuroblastoma. Day 1?? will kick off with an immersive exploration into liquid biopsy research, featuring the #MONALISA Workshop, a new project - the inaugural meeting took place just yesterday. Scientists will delve into the intricacies of circulating nucleic acids, cutting-edge techniques and clinical applications for disease monitoring. The second half of the day holds eye-opening studies, shedding light on the proteomic landscape of extracellular vesicles and providing insights into bone marrow niche changes upon neuroblastoma metastasis. Stay tuned for updates on this remarkable three-day conference. ?? #SIOPEN_TRM2024 #LiquidBiopsy #NeuroblastomaResearch #children #cancer #medicine

Thrilled to announce that my research paper, "A Novel Inhibitor of the Mitochondrial Respiratory Complex I with Uncoupling Properties Exerts Potent Antitumor Activity," has been officially published! After months of dedicated research and hard work during my thesis, I'm excited to share these groundbreaking findings with the world. This article showcases the compelling potential of one of the molecules studied in my thesis, shedding light on its dual action on mitochondria, exhibiting remarkable antitumor properties. ???? Dive into the details of our discoveries by checking out the article here: https://lnkd.in/dQrNagjm Special thanks to my PhD supervisor Eric Fontaine for the invaluable support and guidance throughout this journey, collaborators and everyone who contributed to the work. Passionate about mitochondria as crucial organelles involved in health and disease, I am deeply committed to unravelling their mysteries and exploring their potential in advancing medical science. I believe that understanding the role of mitochondria holds the key to unlocking innovative approaches in cancer and beyond. #Mitochondria #MitochondrialResearch #Antitumor #MedicalScience #CancerResearch #Publication #NatureJournal #ScienceTwitter #BiomedicalResearch

But wait a sec, isn't the premise of research is to be reproducible? and not to be "anecdotal"? I wonder what this muppet did to upset the puppeteer! for those curious what he actually fabricated, can be found on the "office of research integrity" yup, ironically enough we have got one of those lol, here's a link: https://lnkd.in/g_3dAwV6

Recently, I came across an exciting research project led by The University of Texas MD Anderson Cancer Center in collaboration with Axiom Space, BioServe Space Technologies, Deep Space Biology, and Mongoose Bio. This innovative project will send T cells to the International Space Station (ISS) to study the effects of prolonged microgravity on cell differentiation, activation, memory, and exhaustion. As someone deeply interested in biological experiments conducted in space, I am fascinated by the potential of this research to uncover new signaling pathways and identify immune targets that could improve treatment strategies for cancer and other diseases. The intersection of space science and immunology presents a unique opportunity to advance our understanding of cellular therapies and enhance life on Earth. https://lnkd.in/gj3XvPRm