UCLA Technology Development Group的动态

?? Excited to Share Our Latest Publication! ?? I am happy to share with you our new review article "A Review on Ultrasound-based Methods to Image the Distribution of Magnetic Nanoparticles in Biomedical Applications," which has been published in Ultrasound in Medicine & Biology. This review explores the latest ultrasound-based imaging techniques for tracking magnetic nanoparticles (MNPs), offering insights into their potential to enhance precision in medical treatments like targeted drug delivery and cancer therapy, with an emphasis on magnetomotive ultrasound, magnetoacoustic tomography, and thermoacoustic imaging. ?? Key Points: - Real-time imaging capabilities for precise therapy monitoring - Cost-effective alternatives to high-cost imaging modalities like MRI - Key challenges and opportunities for clinical application in MNP-based therapies Ultrasound-guided MNP imaging could bring us closer to safe, accessible, and highly targeted treatment options in oncology, cardiovascular care, and beyond. A big thank you to Theo Pavan for his significant contributions — we collaborated equally on this work. I’m grateful for his insights and partnership in this project! Also a huge thank you to all co-authors and supervisors: Ingrid Ullmann, Christian Heim, Stefan J. Rupitsch, Martin Vossiek, Christoph Alexiou, Helmut Ermert, and Prof. Dr. rer. nat. Dr. habil. med. Stefan Lyer ?? Check out the full article https://lnkd.in/dG95nEk3. #biomedicalengineering #medicalimaging #nanotechnology #ultrasound #research #innovation #magneticnanoparticles

【Novel nanorobots for targeted and enhanced thrombolysis】Tissue plasminogen activator (tPA) is a drug commonly used for thrombolysis, restoring blood flow in patients with acute ischemic stroke. However, the unfocused diffusion of high-dose tPA over the whole body undermines the effectiveness of clot lysis and poses a risk of systemic and brain hemorrhage during treatment. Research team from CU Medicine collaborated with Faculty of Engineering to develop magnetic tPA-anchored nanorobots (tPA-nbots) to treat ischemic stroke. The novel technology exhibits a thrombolysis rate 5 to 20 times faster than traditional treatment and capabilities in recanalising more distal and smaller branches. It demonstrates potential to benefit patients by reducing brain damage and minimising side effects. The team also succeeded in using laser speckle contrast imaging (LSCI) guidance for real-time tracking and delivery of nanorobots and instant monitoring the bloodstream, providing a novel approach for nanorobots-based endovascular intervention therapy. Study results have been published in the international journals Science Advances and Science Robotics. For details: https://bit.ly/3PIWaec Full article (Science Advances): https://lnkd.in/gCHnrE8q Full article (Science Robotics): https://lnkd.in/gbxyGmHy #CUMedicine #tPA #thrombolysis #stroke #nanorobots #LSCI

The Rutgers University Molecular Imaging Core (RUMIC) and the Advanced Preclinical Imaging Lab (APIL) are offering tours through the month April 2024. Each tour consists of a brief presentation, providing an overview of the use and capabilities of the Cores, followed by atwitter short demo for each imaging system. Examples of image processing and data analysis will be presented and the application of imaging technology to research will be discussed. Learn more ?? https://loom.ly/cHhyme4

Cell viability is an important measurement in all biological labs. Currently, it is performed using assay-based methods?that, ironically, kill the very cells that are being checked as live cells. In our recent work (published in #npj imaging), we show that we can utilize the power of nondestructive EPR oxygen imaging for 3D and longitudinal viability assessment. More importantly, it shows that the cells with different seeding densities have different pO2, even in the incubator (are you subjecting your cells to hypoxia unknowingly?). We show that we can assess cells' metabolic activities in biomaterials (how many cells get lost during cell seeding?). This is an important assay for every lab?that works with cells, as different oxygen concentrations can lead to vastly different outcomes. Our instrument, JIVA-25, was utilized for all experiments. Tim Witney Carl Simon Greta Babakhanova Safa Hameed Navin Viswakarma Henry Ahn Check out the full paper here: https://lnkd.in/gRZXx58E

Are you interested in magnetic resonance & preclinical imaging? Subscribe to our ????????????????????! Visit https://lnkd.in/d2bN9qxk #Bruker #MagneticResonance #PreclinicalImaging #Spectroscopy #Analysis #Newsletter

Are you interested in magnetic resonance & preclinical imaging? Subscribe to our ????????????????????! Visit https://lnkd.in/dDmhAfUb #Bruker #MagneticResonance #PreclinicalImaging #Spectroscopy #Analysis #Newsletter

Are you interested in magnetic resonance & preclinical imaging? Subscribe to our ????????????????????! Visit https://lnkd.in/dSTyWCvf #Bruker #MagneticResonance #PreclinicalImaging #Spectroscopy #Analysis #Newsletter

Want a great free conference suggestion? Check out the BioPhotonics 2024 conference with a whole range of interesting talks! Register here: https://lnkd.in/gmBRb5kb Some suppliers to Klein Scientific are presenting, but there is a great program of researcher talks as well. Some highlights: ?? Juliet Gopinath talking about "Advances in STED Microscopy Provide Window into the Brain" - fibre-coupled STED endoscopy! ?? Simon Bush from Prior Scientific presenting on how "Adaptive Autofocus Empowers Time-Lapse Microscopy" - Hardware autofocus can dramatically speed up your imaging! ?? Juergen Popp introduces "A New Era in Blood Testing: Raman Spectroscopy in Point-of-Care Diagnostics" - Raman spectroscopy is a powerful technique, but at the point-of-care is super-cool! ?? Ronian Siew and Edmund Optics presenting on "Compact Microscope System Design: Symmetry Principles, Modalities, and Applications"- I can't wait to see what Ronian discusses, there's a lot at play in microscope design ?? Francesco Saverio Pavone with a very interesting talk "Linear and Nonlinear Optical Imaging Enable Large Area Brain Morpho-Functional Imaging" - Two-photon light sheet, mesoscale light sheet, single-cell resolution! ?? Mike Fussell from Zaber Technologies with "Live Cell Imaging Applications Drive Component and Wavelength Selection for Hyperspectral Microscopy"- imaging beyond the standard visible wavelengths brings a host of advantages to live-cell imaging! ?? Stephan Briggs from Evident Scientific discussing "Microscope Objective Design Considerations for Spatial Biology and Digital Pathology"- Evident have some great objective designs, it will be great to hear more about the principles and considerations What are you attending?

Molecular Imaging Advantages: 1/ Early detection of malignancies 2/ Targeted antibody binding to specific lesions 3/ Precision visualization at the molecular level A game-changer for personalized medicine.

You can improve image clarity, reduce background fluorescence, and optimize cell viability by using media and wash buffers created specifically for live-cell imaging and detection