UC Davis Institute for Psychedelics and Neurotherapeutics的动态

The psychedelic drug psilocybin can change how people perceive time, space, and the self. Researchers are uncovering how the human brain changes after exposure to the drug, so they can harness its therapeutic potential. https://bit.ly/3Xb0jM4 #psilocybin #PsilocybinResearch #brain #BrainResearch #research #science #NIH

Tens of millions of people with depression aren't properly diagnosed. Stanford researchers show that brain imaging could revolutionize treatment. Of the?nearly 1 in 5?people in the United States suffering from depression, many aren't properly diagnosed and end up receiving treatment in a trial-and-error manner, which can be costly, ineffective, frustrating, and, in some cases, damaging. Now, research scientists at Stanford aim to change that by identifying unique biomarkers for each type of depression to match them with targeted treatment. Their findings,?recently published?in a?Nature Medicine?study,?show the results of machine learning and brain imaging in hundreds of patients while doing specific tasks and at rest—helping the team identify six distinct subtypes of depression. https://lnkd.in/gaTqRysB

In a new study, research findings shed light on the relationship between dopamine and decision-making. Published online in Scientific Reports, researchers found differences in how people with Impulse Control Disorder (ICD) process the consequences of their actions compared to those without ICD, both on and off medication. “Our goal was to investigate how factors that influence the decision-making process may also affect how people feel in patients with and without ICD,” said Kenneth Kishida, Ph.D., corresponding author of the study and an associate professor of translational neuroscience and neurosurgery at Wake Forest University School of Medicine. “This study provides insight into the psychological and behavioral aspects of Parkinson’s disease, especially in the context of medication-induced side effects. It also contributes to a broader understanding of how dopaminergic drugs and addictive substances influence decision-making processes and subjective feelings related to risky behaviors.” Learn more: https://bit.ly/4371nlH

Researchers at Washington University School of Medicine administered psilocybin to study participants and captured the resulting brain activity using functional M.R.I. scans. Published in "Nature", the study revealed significant brain changes, particularly in introspective regions. The effects, more pronounced than those from methylphenidate, disrupted the brain's default mode network, enhancing neuroplasticity and potentially aiding in treating depression and anxiety. Although brain activity largely returned to normal after the drug wore off, some lasting changes persisted. This research underscores the therapeutic potential of psychedelics and challenges the notion that their benefits are merely placebo effects. #Psilocybin #MentalHealth #Neuroscience #FunctionalMRI #BrainResearch #Psychedelics #Neuroplasticity #DepressionTreatment #AnxietyRelief #ClinicalResearch #WashingtonUniversity #NatureJournal #Psychopharmacology #DefaultModeNetwork #PsychedelicTherapy https://lnkd.in/g4xv8Qdg

Check out this piece about our recent work

A Dartmouth-led study published in Nature Neuroscience delves into structural and biochemical mechanisms underlying how the human #brain separates emotion generation from #emotion regulation. The researchers analyzed #fMRI data from two independent studies where participants were shown negative images and then asked to recontextualize them to reduce their aversiveness, a process known as #cognitivereappraisal. The study identified specific brain regions involved in emotion regulation, particularly in the anterior #prefrontalcortex. Importantly, these areas were distinct from those generating emotions. This finding highlights the role of cognitive reframing and #abstractthought in emotion regulation. In addition to the structural basis of emotional processing, the study also reports on the #neurochemical basis of emotion regulation, particularly in the context of therapeutic interventions that involve the use of antidepressants and other drugs such as #cannabinoids. The results suggest that the effectiveness of drugs that alter #serotonin levels may be tied to processes of cognitive reframing and self-regulation, emphasizing the need for #psychotherapy alongside pharmaceutical interventions. This integrated approach, which combines basic science with a deeper understanding of drug effects on brain systems and cognitive functions, could lead to more effective #therapeutic strategies. https://ow.ly/qjLR50Sb6Qr

Want to explore a fresh perspective on enhancing response inhibition in the brain? Researchers used multi-channel beta transcranial alternating current stimulation (#tACS) from our #Starstim to target a critical brain network involved in response control. The results are very promising! ?? The #study, conducted with a substantial sample of 118 participants, employed a combination of in-phase and anti-phase stimulation techniques. In-phase stimulation was found to significantly improve response inhibition compared to anti-phase stimulation, while a sham group showed no such effect. ?? Check out the study article here at Elsevier: https://lnkd.in/dVHU2jmn Congrats to the researchers and institutions that made this possible! ?? Qiujian Meng, Ying Zhu, Ye Yuan, Jiafang Liu, Lin Ye, Weimin Kong, Chenxi Yan, Zhen Liang, Fei Yang, Kai Wang and Junjie Bu from Anhui Medical University. #Research #Medtech #Electroceuticals #Technology #Healthtech #Healthcare #Science #Innovation #ResearchArticle #Neuroscience #Neurotechnology #tDCS #BrainStimulation #tES

?? In this fascinating study on depression, our CTO Giulio Ruffini and Brain Modeling Operations Director Ricardo Salvador, alongside Ali Salehinejad, Marzieh AbdI, Mohsen Dadashi, Ahmad Zolghadriha, and Michael Nitsche, utilized our #Starstim device to explore the effects of tDCS, marking a significant step in advancing #depression therapy. ?? This pivotal research compared the efficacy of conventional #tDCS, optimized multichannel tDCS, and sham tDCS on patients with major depression. Results revealed that both active tDCS treatments significantly reduced depressive symptoms, with the multichannel approach demonstrating a notably larger effect size. Find out more about the methods used and results of this #research study here: https://lnkd.in/dbf6CgCW ?? Kudos to the brilliant minds behind this innovative research! #Medtech #Electroceuticals #Technology #Healthtech #Healthcare #Science #Innovation #Study #ResearchArticle #Neuroscience #Neurotechnology #BrainStimulation #tES #MDD

With the FDA planning to decide on the use of MDMA as a PTSD treatment in August, take a moment to explore the latest research?on MDMA and other psychedelic compounds' therapeutic potential in a?special collection from American Chemical Society Neuroscience. Read more at the link below. #psychedelictherapy #neurotherapeutics