Source BioScience的动态

?? New post ?? Are you looking to accurately measure DNA or RNA levels in your samples with unparalleled precision and efficiency? Source Genomics offers cutting-edge qPCR services designed to meet your research needs. Discover more about qPCR by reading our latest post "Enhance Your Research with Source Genomics qPCR Services" here ?? https://lnkd.in/e2dH6YBj #Genomics #SangerSequencing #NGS #Sequencing #GenomeMapping #Biomarkers #BiomarkerDiscovery #Multiomics #DrugDiscovery #qPCR #TheSequencingPeople #Science #LifeScience

INTEGRA's best PCR purification and NGS size selection solutions! The reliability of #PCRpurification and #NGSsizeselection is paramount in the rapidly evolving field of #genetics and #genomics. Magnetic bead-based methods play a vital role in preparing DNA samples for downstream analysis and ensuring the removal of unwanted contaminants and fragments. Whether your focus is on PCR purification to isolate amplified DNA products, or NGS size selection targeting specific fragment sizes for efficient sequencing, our solutions are tailored to enhance your genomics workflows. Discover which product bundle best suits your laboratory's needs!? Contact us to discuss your application requirements and learn how our tailored solutions can streamline your genomics workflows. #MAGmodules #ASSISTplus #VOYAGER #pipetting #AccelerateScientificDiscovery

INTEGRA's best PCR purification and NGS size selection solutions ?? The reliability of #PCR purification and #NGS size selection is paramount in the rapidly evolving field of #genetics and #genomics. Magnetic bead-based methods play a vital role in preparing DNA samples for downstream analysis and ensuring the removal of unwanted contaminants and fragments. Whether your focus is on PCR purification to isolate amplified DNA products, or NGS size selection targeting specific fragment sizes for efficient sequencing, our solutions are tailored to enhance your genomics workflows. Discover which product bundle best suits your laboratory's needs! Contact us via DM to discuss your application requirements and learn how our tailored solutions can streamline your genomics workflows. #MAGmodules #ASSISTplus #VOYAGER #pipetting

We’re in the business of tracking avian flu because this virus doesn’t mess around. It mutates, it spreads— it’s always up to something, and it’s our job to keep up. No room for guesswork here; we need #speed, #accuracy, and #reliability, plain and simple. Enter Oxford Nanopore Technologies R10 chemistry. It’s fast, it’s accurate, and it cracks the toughest parts of the genome—like the multibasic cleavage site—without breaking a sweat. #Science that actually works when it counts? Hell yes. Massive shoutout to Peter Thielen, Jeremy Ratcliff, Dr. Jurre Y Siegers, Sokhoun Yann Brian Merritt and the entire team making this happen (Apologies if I didn’t name-drop everyone here—but you know who you are!) Check out the full story here: https://lnkd.in/gp9nPDqV And this isn’t just hype. We’ve already put R10 to work on the recent #H5N1 cases in #Cambodia. With this tech, we confirmed a new reassortant virus and nailed down that the cases were bird-to-human, not human-to-human. That’s a BIG deal for outbreak response—speed and confidence, exactly when it matters. Get the details here: https://lnkd.in/gXpzuPAK #GenomicSurveillance #OutbreakResponse #PublicHealth #AvianInfluenza #OneHealth #InfectiousDisease #Epidemiology #PandemicPreparedness #VirusTracking #RapidResponse #GlobalHealth #ZoonoticDiseases #HealthSecurity

Back-to-back manuscripts this week highlight how better flu genome sequencing can improve #H5N1 outbreak responses. Both use iiMS-PCR, a molecular approach we refined to address systematic barriers between sample collection and data availability. https://tiny.cc/iimspcr First, Jeremy Ratcliff and Erik Karlsson's team showed that Oxford Nanopore’s R10 chemistry isn’t just better per-base quality, it also reduces insertions and deletions that previously limited resolution of highly pathogenic sequence motifs. https://lnkd.in/e9hTBy_T Second, Dr. Jurre Y Siegers and Erik Karlsson used it for #H5N1 emergence response in Cambodia, where repeat jumps from birds to humans started in early 2023. Reassortment of 2.3.2.1c, 2.3.4.4b, and other mutations enable transmission to mammalian hosts. https://tiny.cc/camboh5n1 In both studies, we used an optimized version of multi-segment PCR that integrates indexing into the RT-PCR (iiMS-PCR). Our team @JHUAPL worked closely with @NEBiolabs to push molecular biology further, which is now available as a NEBNext protocol. https://lnkd.in/eazC2cHi Special thanks to everyone involved in the rapid response efforts as we enter an unprecedented period of HPAI #H5N1 transmission from animals to humans, both overseas and in the United States. #InfluenzaResearch | #H5N1 | #VirusEvolution

Discover some of Novogene's services that can be applied to the study of plant and animal microbiomes: Shotgun-based metagenomic sequencing: https://bit.ly/3k7naaB. Amplicon-based metagenomics sequencing: https://bit.ly/3W0SMf5. Metatranscriptomics: https://bit.ly/3X25JXi

?? New Development in Single-cell RNAseq! ?? Sharing a new tool for scRNAseq demultiplexing detailed in a recent bioRxiv article, "demuxSNP: supervised demultiplexing scRNAseq using cell hashing and SNPs" by Michael P. Lynch, Yufei Wang, Laurent Gatto, and Aedin C. Culhane. ?? demuxSNP is a supervised algorithm that improves the accuracy of demultiplexing by integrating cell hashing with SNPs. ?? Uses genetic variation to train a KNN classifier, enhancing the prediction of demultiplexing classes for cells that are unassigned or of uncertain status. ?? Shows better performance over existing methods, particularly in scenarios of low hashing quality or high doublet rates, enabling the recovery of more high-quality RNA cells. ?? bioRxiv paper: https://buff.ly/4abTQUE ???? R package: https://buff.ly/3UG8JsE ?? Join the Conversation ?? Share your ideas, methods, and tools in the comments! ?? ?? #SingleCell #RNAseq #Genomics #Bioinformatics #demuxSNP #CellHashing #InnovationInScience

Imagine a microscopic game of 'Where's Waldo?' but for genes! Microarray tech puts thousands of DNA probes on a tiny chip allowing simultaneous analysis of thousands of genetic markers. From understanding disease predispositions to unraveling ancestry, revealing genetic mysteries in your samples is a boundless pursuit with microarrays. https://hubs.ly/Q02trKC30 #Biotechnology #ClinicalResearch #Genomics

?? New Feature Alert on GeneBe! ?? We are excited to announce the launch of a new experimental yet functional feature on GeneBe – ACMG Score Assignment for Copy Number Variations (CNVs)! This feature follows the Technical Standards for the Interpretation and Reporting of Constitutional Copy Number Variants as recommended by the American College of Medical Genetics and Genomics (ACMG) and ClinGen. It's designed to assist in the evaluation of CNVs, offering streamlined insights for genetic professionals. ?? Check out an example CNV report for a deletion on chr7 here: DEL chr7:72,846,244-74,187,855 -- https://lnkd.in/dFKJwgmn Please note, this functionality currently supports only Human Genome version 38 (hg38). We’re confident this tool will be useful, but as it's still in the experimental stage, your feedback is invaluable! We’d love to hear your thoughts and suggestions. ?? #GeneBe #ACMG #CNV #Genomics #Bioinformatics #GeneticTesting

Recent research shows that cell-free DNA (cfDNA) is a critical component of touch DNA samples, and recovery and purification of this material are essential for obtaining valuable genetic information. Improving the recovery and purification of cfDNA is critical to the development of fragmented cfDNA as a valuable source of genetic information in future analyses. Take 3 minutes to read more in our blog post: https://bit.ly/3TKUBin You can also check out BioChain’s cfPure kits here: https://bit.ly/3N5IWrk #extractionkits #genomics #NGS #clinicalresearch #automation