In this review, SCGE researchers resolve seemingly conflicting findings by considering the different transepithelial voltages and resultant movement of Cl? during short-circuit and physiological open-circuit conditions. This analysis indicates that behavior under short-circuit conditions cannot be directly extrapolated to infer behavior under physiologic conditions. They also discuss the potential role for basolateral Cl? channels in controlling absorption and secretion in ionocytes. https://lnkd.in/dQCQAVck #publication #science
