Sania Jafar的动态

?? Completed "The Science of Stem Cells" course offered by the American Museum of Natural History on Coursera. ?? Explored stem cell history, biology, and cutting-edge research techniques. ?? Learned about the potential for medical breakthroughs and individualized medicine. ?? Examined bioethics experts' perspectives on the ethical implications of stem cell research and therapy. ?? Completed in 10 hours. #StemCellResearch #MedicalInnovation

#sciaticnervedefect #chitosanconduit #fibrincollagenhydrogel #mesenchymalstemcell #repair Chitosan conduits enriched with fibrin-collagen hydrogel with or without adipose-derived mesenchymal stem cells for the repair of 15-mm-long sciatic nerve defect https://lnkd.in/gESkqe3M Università degli Studi di Torino Hollow conduits of natural or synthetic origins have shown acceptable regeneration results in short nerve gap repair; however, results are still not comparable with the current gold standard technique “autografts”. Hollow conduits do not provide a successful regeneration outcome when it comes to critical nerve gap repair. Enriching the lumen of conduits with different extracellular materials and cells could provide a better biomimicry of the natural nerve regenerating environment and is expected to ameliorate the conduit performance. In this study, we evaluated nerve regeneration in vivo using hollow chitosan conduits or conduits enriched with fibrin-collagen hydrogels alone or with the further addition of adipose-derived mesenchymal stem cells in a 15 mm rat sciatic nerve transection model. Unexpected changes in the hydrogel consistency and structural stability in vivo led to a failure of nerve regeneration after 15 weeks. Nevertheless, the molecular assessment in the early regeneration phase (7, 14, and 28 days) has shown an upregulation of useful regenerative genes in hydrogel enriched conduits compared with the hollow ones. Hydrogels composed of fibrin-collagen were able to upregulate the expression of soluble NRG1, a growth factor that plays an important role in Schwann cell transdifferentiation. The further enrichment with adipose-derived mesenchymal stem cells has led to the upregulation of other important genes such as ErbB2, VEGF-A, BDNF, c-Jun, and ATF3.

Hot off the press. Glad to share our research article out in ACS Nano from ACS Publications on "Cross-Modal Imaging Reveals Nanoparticle Uptake Dynamics in Hematopoietic Bone Marrow during Inflammation". We developed imaging tools aimed at studying nanoparticle uptake dynamics in the bone marrow niche under varying levels of inflammation. Many congratulations and thanks to all the co-authors who contributed their expertise to this project. Thanks to Technion - Israel Institute of Technology,?Faculty of Biomedical Engineering, Technion,?Teva Pharmaceuticals for the support. The article can be read here. https://lnkd.in/g2g4Ct6x American Chemical Society #Multiscaleimaging #biomedicalengineering #nanotechnology #mri #inflammation #nanoparticles #fluorescence #microscopy #contrastimaging #smallanimalimaging #invivomiceimaging

Are you wanting to be part of one of the first German universities to offer an international masters degree in #Stem Cell Medicine? Your #Master will prepare you for a career in one of the most fascinating, modern and promising fields of #medicine. Stem #cell research is central to our understanding of how human life develops as well as how it leads us to the discovery of novel drugs using stem-cell based #disease models and cellular therapies in #regenerative medicine. Cellular reprogramming of somatic cells to induced, pluripotent stem (#iPS) cells as well as direct cell transdifferentiations using combinations of transcription factors are the latest developments in these directions.?We predict that in the near future, a strong demand of educated #biochemists with backgrounds in stem cell and regenerative medicine will find their places in basic #research, medical research institutions, medicinal practices and in the #pharmaceutical industry. This demands in turn an advanced interdisciplinary educational approach starting in the field of chemistry of small #molecules, bioinformatics of nucleic acids and protein networks, #biochemistry of transcription factors, genetics and #epigenetics, systems biology as well as #nanotechnology and material sciences combined with molecular developmental and medicine training. Head over to our website to find out more about career opportunities and #scholarships: https://lnkd.in/etbWMnKc The program consists of a total of ten #modules spread over three semesters and a total number of 90 credit points will be awarded. The modules are designed consecutively with no elective modules. However, individual arrangements allow you a high degree of flexibility and mobility. At the end of your studies, you will recieve a final #degree of Master of Science in Stem Cell Medicine. To find out more about #academics and the schedule, go to our website: https://lnkd.in/etbWMnKc The Master program offered by Ruhr-Universit?t Bochum?invites you to chart the course for the medicine of the future, in #StemCell, regenerative medicine. Pssst: There is an early bird offer until March 1st, 2024! ??

Mechanism to reactivate dormant neural stem cells In this study, the team discovered that a specific group of proteins play an essential role in “waking up” dormant neural stem cells through a process called SUMOylation. In SUMOylation, a small protein named SUMO (small ubiquitin-like modifier) tags target proteins inside a cell to influence their activity and/or function. These SUMO-tagged proteins, the researchers found, trigger the reactivation of neural stem cells, allowing them to contribute to brain development and repair. Conversely, without SUMO proteins present, the fruit flies produced a microcephaly-like phenotype. This is the first study to pinpoint the SUMO protein family’s exact role in the reactivation of neural stem cells. #ScienceMission #sciencenewshighlights https://lnkd.in/gnRrvpMn

"Completed 'The Science of Stem Cells' course by the American Museum of Natural History! Through the Coursera Project Network Gained valuable insights into: - Stem cell types and functions - Tissue engineering and regeneration - Stem cell therapies and challenges - Bioethical considerations Enhanced my understanding of this rapidly evolving field. I highly recommend it for science enthusiasts! #StemCellBiology #AmericanMuseumOfNaturalHistory #CourseCompletion #ScienceLearning #CellBiology" https://lnkd.in/dvRd9vzt

Artificial Wharton's Jelly Biochemazone? introduces Artificial Wharton's Jelly (BZ420) – a game-changing simulated fluid designed for in vitro research on regenerative medicine, stem cell studies, and tissue engineering. Mimicking the unique properties of natural Wharton’s Jelly, it ensures consistency and precision for groundbreaking scientific discoveries. ?? Key Details: pH: 7.0 (Customizable on request) Pack Sizes: 100 mL, 200 mL, 500 mL, 1000 mL Storage: Store at 2-8℃; transportable at room temperature Shelf Life: 6 months ?? Take your research to the next level: https://lnkd.in/gMAYhG8f #Biochemazone #ArtificialWhartonsJelly #StemCellResearch #TissueEngineering #InVitroStudies

Articles published in Journal of Stem Cell Research are high-quality, clinical and basic, influential research articles by established academic authors as well as new researchers. The paramount objective of?JSCR is to showcase and promote distinguished research in the field of stem cells, to help advance development of this field. The types of articles published in?JSCR?include Editorial, Opinion Review, Frontier, Review, Minireview, Clinical Research, Basic Study, Systematic Review, Meta-analysis, Evidence-based Medicine, Field of Vision, Clinical Guidelines, Letter to the Editor, and Case Report. Access our journal here: https://lnkd.in/dziuvQgr Submit work online: https://lnkd.in/gdU5iHy #STEMCELL #regenbiol #regenerativemedicine #stemcellbiol #cellbiology #stemcelltherapy #regenbiology #submitnow

Discover the Magic of Stem Cells in Healing! As stem cells circulate in the body, they detect damaged cells and tissues in the body and migrate toward the site to exert repair and regeneration effects. ?? How Do Stem Cells Work? Stem cells are the body's raw materials—cells from which all other cells with specialized functions are generated. But their role doesn’t stop at just creating new cells; they are also our internal repair system. As they circulate through the body, stem cells have the remarkable ability to detect damaged cells and tissues. Dm for more information #MedicalWellnessTourism #StemCellTherapy #Wellness #Medical #Tourism #Health #HealthisWealth #SexCellTherapy #FatCellTherapy #BloodCelTherapy #StemCellMentalHealth #Doctor #Proffesor #MentalHealthAwareness #BoneCellTherapy #??

?? Excited to share that I have completed the "Science of Stem Cells" course by the American Museum of Natural History! ???? Throughout the course, I gained valuable insights into: - **Introduction to Stem Cells**: Understanding their fundamental properties and the history of stem cell research. - **Stem Cell Functionality**: Learning about differentiation, mitochondrial replacement therapy, and organ transplantation technologies. - **Disease Modeling**: Using cultured stem cells to study diseases like Alzheimer’s and diabetes. - **Therapeutic Applications**: Exploring treatments for diseases such as age-related macular degeneration using adult stem cells. - **Bioethics**: Engaging in discussions on the ethical, legal, and policy challenges in stem cell research and therapy. This course has deepened my understanding of stem cell science and its incredible potential in both research and clinical applications. #StemCells #ScienceEducation #AMNH #LifelongLearning #Biotechnology