Quotient Therapeutics的动态

A recent Nature publication featured in a NYT article identified APOE homozygosity as a genetically distinct form of Alzheimer Disease. Could this or another hereditary dementia be the cause of your patient’s symptoms of cognitive decline? Choose Genomic Unity? Dementia Analysis for comprehensive testing of small sequence changes, CNVs, inversions, C9orf72 repeat expansions and APOE status - all in one test. https://ow.ly/WiLQ50RzOiO

???Disease Models - The Key to Unlocking Treatments for STXBP1 ???https://lnkd.in/enED9zEx Our latest blog post, written by Sagi Gidali, explores?the critical role disease models play in our mission to find treatments for STXBP1 disorders. From C. elegans worms to cutting-edge human cell systems, these models are helping us unlock new therapeutic possibilities. Read the blog to learn more about how these models are pushing the boundaries of genetic research and?making strides in understanding and treating STXBP1??? #RafasMoonshot #STXBP1 #DiseaseModels #RareDiseaseResearch #InnovativeMedicine

ABeta42 (Amyloid beta 42) is found to be accumulated in AD (Alzheimer's Disease) patients' brains, forming plaques (refer to ref. 1). Drosophila melanogaster can be a useful model system to study about the accumulations of ABeta42 protein plaques and NFTs (neurofibrillary tangles) in the developing fly compound eyes at the 3rd instar larval stage. The mutant fruit flies had shown neurodegenerative symptoms associated with microtubule destabilization problems (Ref. 1). Ref. 1) https://lnkd.in/grDpnrmQ

“Remarkably, these alterations overlapped substantially with changes in age-related neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease.“ Is it remarkable if others have called attention to this before COVID19 ever happened? Ruth Itzhaki, Brian Balin and others have raised the issue of microbial #infections for 3 DECADES. Same idea, different organisms. Whether microbes directly invade or impact the brain from afar…they deserve attention. #microbiome #SARSCoV2 #Cytokines #pathobiome #herpes #chlamydia #lyme #Borrelia #perioInfections The Alzheimer's Pathobiome Initiative (AlzPI)

Quantifying Mitochondrial Dynamics and Function in Fibroblasts with Primary Mitochondrial Disease Shilpa Iyer from the University of Arkansas, USA, shared her research at #TargetingMitochondria2024, focusing on the quantification of mitochondrial dynamics and function in fibroblasts linked to mitochondrial DNA mutations and deletions. This work deepens our understanding of how these genetic alterations impact mitochondrial health, potentially guiding future therapeutic approaches for primary mitochondrial diseases. #WorldMitochondriaSociety #TargetingMitochondria #mitochondria #mitochondrialdisease #mitochondrialdynamics #fibroblasts

This is the “semantic tree” and up to date for 2024 if you want to truly understand the complexity or cancer evolution and metastatic progression. It is not either or- it is inclusive of all research done to date on cancer. Criticism: the graphic visually neglects the key points that nutrition, microbiome, exercise and mind body aspect of healing likely impacts ALL the other pieces and neglect on these issues are likely driving our cancer risk in “industrialized” nations higher. Whereas drugs targeting a mechanism does not affect the holistic picture as dramatically and whatever benefits that do occur only last as long as the drug works not to mention the side effects. Not focusing more % research $$ on a more holistic approach to cancer care and prevention integrated with our new IP drugs is just idiocy at this point of science.

This wonderful new paper provides a great overview of the complexity of cancer - it is never about one aspect, whether it's a genetic driver mutation or metabolism or any single lens. The complexity of cancer is where integrative oncology shines, matching this web with a personalised and diverse toolkit of IO interventions, from nutrition, physical activity, sleep, stress management and circadian rhythm regulation to environmental exposures, microbiome and epigenetic impacts and beyond. Highly recommended reading! https://lnkd.in/eKx4y6Gy #cancercare #integrativehealth #cancersupport #integrativeoncology #integrativemedicine

The Complexity of the NNIVEE System...

https://lnkd.in/es2ykXmm Involvement of Tau derived phosphorylated peptides in NMDAR signaling and Alzheimer's Disease pathogenesis

Intermittent fasting on a 5:2 schedule has been shown to protect against liver inflammation and liver cancer in mice. The fasting regimen led to metabolic changes, such as increased breakdown of fatty acids and decreased build-up of fats, which combat nonalcoholic fatty liver disease and related conditions like cirrhosis and liver cancer. Researchers are hopeful that these findings may have implications for human health as well. Hashtags: #IntermittentFasting #LiverHealth #Biohacking #HealthResearch #WellnessScientific Read more here: https://lnkd.in/eixKhbkP BioMedHack.com is your leading source for the latest news, breakthroughs, and insights in medicine, biohacking, and alternative medicine. Our mission is to help you live healthier and longer by bringing you cutting-edge information and expert advice. Follow us on Facebook, Instagram, and X.