Precision Genomics Collaboratory的动态

? Thrilled to share our new publication: "Spatiotemporal transcriptomic mapping of regenerative inflammation in skeletal muscle reveals a dynamic multilayered tissue architecture," now out in The Journal of Clinical Investigation ???? In this study, we delve into the complex spatial and functional diversity of macrophages in muscle regeneration and dystrophy. Our findings reveal how macrophage subsets organize into distinct zones around damaged myofibers, forming multilayered regenerative inflammation zones (RIZs) that are crucial for effective tissue repair and are sensitive to glucocorticoids. Grateful to my mentor Laszlo Nagy, M.D., Ph.D. and co-author Laszlo Halasz for their invaluable contributions to this work. I also extend my thanks to all the other authors, particularly Darby Oleksak, technical and administrative staff from Johns Hopkins All Children's Hospital and collaborators from University of Florida, University of Debrecen, and Max Delbrück Center whose efforts made this research possible. This research was supported by a Muscular Dystrophy Association Development grant and a Johns Hopkins All Children's Hospital Foundation/ACRI fellowship. #muscleregeneration #regenerativeinflammation #spatialbiology #transcriptomics #macrophages #tissuerepair #scientificresearch

Another great (and free!) resource from Front Line Genomics has just been published, covering all things #multiomics. So, if you're interesting in the power of combining #transcriptomics, #epigenetics, #proteomics and more, this is the guide for you! We also have a couple more exciting launches coming soon, so stay tuned ??

Today I cycled around the Hsinchu Biomedical Science Park. It's a beautiful and pleasant place. The Hsinchu Biomedical Science Park is located near the Hsinchu High Speed Rail Station, and since it is close to where I live, I sometimes go for a walk there to check on the progress. Since the concept was announced by the Taiwanese government in 2005, the science park has been steadily built over the past 20 years. As expected, Taiwan has built the science park based on a grand design (business model) based on a long-term vision, and the industry has also developed. On a site of 38.3 km2, six research bases have been set up, including a hadron cancer treatment center, cancer medicine, vascular cardiology, clinical genomics, clinical regenerative medicine, clinical photoelectron medicine, and medical imaging, making it a base for medical research and development industrialization in Asia. The National Taiwan University Hospital is at the core of this science park, and the joint venture between National Taiwan University and private companies is at the center of the science park, which is based on collaboration by establishing research and development bases and attracting companies. Recently, people from all over the world have been gathering, and construction of many elementary schools, junior high schools, and high schools has begun, and it is steadily developing. Taiwan's greatness is that it proceeds with things based on a grand design (business model) based on a long-term vision. That is why Taiwan has been able to accumulate technologies that the world cannot imitate, and Taiwan increase the value of the country. I feel excited every day. It is completely different from some countries that only think about short-term economic effects.

‘Columbia University announced today that it is being given $400 million by alumni Roy and Diana Vagelos. The gift, the largest single contribution ever made to Columbia’s medical school, will be used to establish the Roy and Diana Vagelos Institute for Basic Biomedical Science. The focus of the new institute will be to train physician-scientists to transform basic biomedical discoveries into new treatments for a host of different diseases, including blood and immune system disorders, cancers, metabolic disorders, and inflammatory, neurological, and cardiovascular conditions. Columbia plans for the new institute to bring together the research being conducted in its basic science departments, medical and graduate education programs, and in its various clinical departments. According to the university, the intent is to “build the world’s foremost ecosystem for biomedical research and to attract the next generation of exceptionally creative and collaborative scientists able to realize this vision.” A portion of the gift will be used to boost funding for the medical school’s programs in cell engineering and gene therapy. In addition, the gift also will support construction of a new biomedical research building, which will be called Vagelos Innovation Laboratories. It will be located on Columbia’s Washington Heights medical campus, and will be, according to the university, the first university-owned research building in New York City that will not rely on fossil fuels.’ #research #science #healthcare #stem #cellengineering #genetherapy #biomedicalengineering #medical #biomedicalresearch #innovation #biotech #healthcare https://lnkd.in/emk2PdAx

I recently explored the incredible science of stem cells at #TheAmericanMuseumofNaturalHistory. Their unique ability to regenerate and differentiate holds immense potential for medical advancements. As a Molecular Medicine student at Ziauddin University, I’m thrilled to apply this knowledge in my capstone project on neuronal differentiation using dental-pulp-derived stem cells! On 28th February, 2023 #StemCells #MolecularMedicine #CapstoneProject

From single molecules to network activity: Two post-doctoral positions available to study molecular and physiological aspects of synaptic plasticity funded by ANR. We are seeking to recruit two post-doctoral fellows interested in cellular and molecular neuroscience with strong expertise in either cell/molecular biology or slice imaging/physiology, including glutamate receptor structure function, spine morpho-dynamics, synaptic plasticity, receptor trafficking and nanoscale organization to join a vibrant environment and exciting projects associating astute molecular manipulations, genetic code expansion, high resolution imaging, biosensors and slice imaging and electrophysiology to study innovative aspects of synaptic plasticity. Competences For these positions, we are seeking highly motivated and competent individuals, with a proven track record of success and expertise in either cell biology, slice physiology or imaging, if possible immediately after their PhD, and in any case no more than two years after their PhD. The projects will be conducted in a stimulating and highly interdisciplinary and international environment in a recent research building, a part of the Bordeaux neurocampus project (Bordeaux, France). ? More info on the team research here: https://lnkd.in/dYX_w-yd Please send CV and two independently sent references to: [email protected] ? 1???????????Bessa-Neto, D., Beliu, G., .., Sauer, M. & Choquet, D. Bioorthogonal labeling of transmembrane proteins with non-canonical amino acids unveils masked epitopes in live neurons. Nat Commun 12, 6715, (2021). DOI: 10.1038/s41467-021-27025-w 2???????????Budiarta, M., Streit, M. & Beliu, G. Site-specific protein labeling strategies for super-resolution microscopy. Current opinion in chemical biology 80, 102445, (2024). DOI: 10.1016/j.cbpa.2024.102445 3???????????Nowacka, A., Getz, A., .., A., . . . Choquet, D. Synapse specific and plasticity-regulated AMPAR mobility tunes synaptic integration. BioRXive, (2024). DOI: 10.1101/2024.03.19.584837 4???????????Getz, A. M., Ducros, M., .. Choquet, D. High-resolution imaging and manipulation of endogenous AMPA receptor surface mobility during synaptic plasticity and learning. Science advances 8, eabm5298, (2022). DOI: 10.1126/sciadv.abm5298

Texas A&M Health is the first institution in the nation to be awarded a National Institutes of Health (NIH) training grant specifically targeting lymphatic biology and medicine! The funding will support two School of Medicine PhD students per year selected for the LYMphatics in Pathology and Health (LYMPH) Training Program, which aims to train the next generation of lymphatic biologists in pursuit of a deeper understanding of the molecular mechanisms, physiological systems and clinical applications of lymphatic research. This training grant is the first of its kind in the nation, as lymphatic biology is a relatively new field of study in medicine, and is now gaining traction as an area of special interest by the NIH. It has been historically underfunded despite playing a central role in many of the body’s processes, including fluid balance, immune function and waste removal, which collectively involve every organ system in the body. This means the lymphatic system is another avenue by which scientists can research disease processes and identify potential treatments. Learn more about the program: tx.ag/YLeu7cx

Know someone eager to coupe Spatial genomics with CRISPR screens as a postdoc at Columbia University? Let's decipher cancer-immune interactions! Postdoc in Spatial genomics x CRISPR screens at Columbia University Columbia University See the full job description on jobRxiv: https://lnkd.in/d8WPNyPm #cancer #CRISPR_screen #organoids #pooled_crispr_screens #spatial_multiomics #spatial_transcriptomics #tumor_microenvironment

Attention : Postdoctoral Fellow Organization Bethesda, MD and surrounding area Scientific focus area Biomedical Engineering and Biophysics, Cell Biology, Neuroscience About the position The Section on Sensory Cells and Circuits led by Senior Investigator Alexander Chesler, Ph.D., at the National Institutes of Health (NIH) is recruiting a postdoctoral fellow for fully funded research to study the molecular and cellular mechanisms underlying somatosensation, interoception, and pain. The central question guiding our research is how sensory input is detected and processed by the brain to evoke specific behaviors, sensations, and emotions. Our work focuses on identifying peripheral sensory neurons tuned to specific types of stimuli, the molecules they use for transduction, and the neural circuits they activate. Through our research we seek to understand (1) how defined sensory inputs elicit bodily responses, (2) the basis by which some stimuli are perceived as innocuous and others noxious, and (3) how these distinctions are modulated by physiological state or prior experience. The hope is that improving our knowledge of these basic mechanisms will be useful in developing new therapeutic approaches for treating pain and interoceptive disorders. Application Link : https://lnkd.in/gVx-qGBp

Hot off the press. Glad to share our research article out in ACS Nano from ACS Publications on "Cross-Modal Imaging Reveals Nanoparticle Uptake Dynamics in Hematopoietic Bone Marrow during Inflammation". We developed imaging tools aimed at studying nanoparticle uptake dynamics in the bone marrow niche under varying levels of inflammation. Many congratulations and thanks to all the co-authors who contributed their expertise to this project. Thanks to Technion - Israel Institute of Technology,?Faculty of Biomedical Engineering, Technion,?Teva Pharmaceuticals for the support. The article can be read here. https://lnkd.in/g2g4Ct6x American Chemical Society #Multiscaleimaging #biomedicalengineering #nanotechnology #mri #inflammation #nanoparticles #fluorescence #microscopy #contrastimaging #smallanimalimaging #invivomiceimaging