Pragma Bio的动态

Love this recent Genetic Engineering & Biotechnology News article on what’s hot in reprogramming life! The article features a fresh perspective from Daniel de la Torre, a wonderful R&D leader, scientist, and communicator at Constructive Bio! Check it out to stay up-to-date on the latest advancements in genetic engineering and biotechnology. #geneticengineering #biotechnology

Advancing protein engineering with Dirichlet latent models Engineering proteins with specific functions is essential for progress in biotechnology and medicine, yet traditional methods, such as Directed Evolution, are often costly and inefficient. Recently, Lobzaev and Stracquadanio introduced the Temporal Dirichlet Variational Autoencoder (TDVAE), an innovative model that predicts mutation effects and generates functional protein variants based solely on sequence information. Unlike traditional Gaussian models, which average out data variations, Dirichlet-based models capture the unique statistical properties of protein sequences more effectively. This is particularly valuable when designing proteins with targeted functions, especially in cases where few similar sequences are available to guide the process. TDVAE’s use of the Dirichlet distribution enables it to model the multi-modal, discrete nature of amino acid distributions—a challenge for Gaussian models. By mapping protein families to this distribution, TDVAE reveals deeper patterns in amino acid relationships and predicts mutation effects with high accuracy. Temporal Convolutional Networks (TCNs) further enhance TDVAE’s ability to process sequence data efficiently, accurately predicting mutation impacts without relying on experimental input. TDVAE has already shown promise in designing variants of human α-galactosidase, an enzyme critical in treating Fabry disease. It generates diverse libraries of functional protein variants that retain the essential biochemical properties of the original protein while minimizing harmful mutations. Paper: https://lnkd.in/e7DSaxxH #DirichletModels #ProteinEngineering #GenerativeAI #VariationalAutoencoders #DeepLearningModels #Autoencoders #LatentSpace #Biotechnology #MLResearch #DataDrivenScience #AIForScience #UnsupervisedLearning #AIModels #ComputationalBiology #Bioinformatics

Thanks to Arik for his diligent work on this paper summarizing our regulation of GEMs workshop and beyond!

Come join us for the debate "AI in Bioengineering: a powerful alliance?" and dive into the fascinating world of artificial intelligence in Bioengineering! Team up with specialists to explore the challenges, benefits and ethical questions behind this impactful partnership between technology and biology. Uncover how AI is revolutionizing this field and prepare yourself to expand your horizons, understanding the future of Bioengineering. Come be a part of a crucial conversation for the advancement of science! #IXSBE2024?#SemanadaBioengenharia?#Bioengineering?#Biotechnology?#Nanosystems?#RegenerativeandPrecisionMedicine?#BiologicalEngineering?#Microbiology?#PharmaceuticalEngineering?#tecnico?#ist

???????????????? ?????????? ???? ?????? ?????????????????? ?????? ???????? ???????????? ??????@?https://lnkd.in/dtUSFjWX The DNA Synthesis?Industry?is advancing quickly, with innovations that enable researchers to customize genetic material for applications across fields like healthcare, agriculture, and biotechnology. The market is projected to grow significantly as demand for synthetic DNA accelerates, driven by developments in genetic research, personalized medicine, and sustainable agriculture solutions. Key growth drivers include: ?? Rising investments in synthetic biology and gene editing technologies ?? Increased applications in biopharmaceutical development and precision medicine ?? Advancements in automated synthesis platforms that increase efficiency and accuracy DNA synthesis technology is reshaping research and clinical diagnostics, making it easier to create precise DNA sequences that open doors to novel treatments and more resilient agricultural crops. The future of genetic engineering is here, powering breakthroughs from lab to field. Major industry players include?GenScript, Thermo Fisher Scientific, Bioneer, Twist Bioscience, Eton Bioscience, IBA, LGC Biosearch Technologies, Eurofins, Quintara Biosciences, Integrated DNA Technologies #DNASynthesis #GeneticEngineering #SyntheticBiology #TwistBioscience #ThermoFisher #GenScript #IntegratedDNA #PrecisionMedicine #BiotechInnovation #AgriculturalBiotech #LifeSciences #HealthcareInnovation #GenomicResearch #MedicalAdvancements #LabTechnology #FutureOfBiotech?

I have always been amazed how many of the statistical methods that we regularly use in genomic research originate from other research disciplines, such as economics. Yet, life scientists have transformed interdisciplinary transferred methods to cornerstone tools in the analysis of disease-gene associations. Thus, I have been curious as to what might happen if we apply the methods and tools we use in the life sciences to a different discipline? Our recent work applies a commonly used disease-gene association statistical test to the links between patents and academic literature, which has just been published: https://lnkd.in/eM-NuUsd Here are some of my personal highlights that I learned during this small project. I was impressed by the quality of patent classification, which makes it easy to identify groups/classes of patents related to specific innovations (e.g., immune therapy with antibodies) or research methods (e.g., probabilistic gene regulatory networks). Databases that index patents and literatures, and allow for cross-links of patents and literature, while also making the connections between inventors, authors, research institutions, and companies are a treasure trove (thanks to The Lens for providing free access to their database) I found it refreshing to analyze data outside my typical domain, and reading up on what researchers do in a different discipline gave me some new ideas. Overall, I hope you too will enjoy our recent work. Did you have any recent interesting experiences from interdisciplinary research?

Check out this informative article on effective measures to make cells active in experimental research. It explains the importance of cells in biological experiments and provides tips on how to activate them for better results. #biology #research #cellactivation https://lnkd.in/grqrDQew

Microbiology Isn't Boring... It's ALIVE! If you think microbiology is just a bunch of petri dishes and tiny organisms, think again. Let's talk about the fascinating world where the unseen becomes the most important player! Did you know?The human body is home to trillions of microbes that keep us healthy. Without them, digestion, immunity, and even mental health could go haywire! Microbes are shaping the future of medicine. From CRISPR gene editing to phage therapy, they are the unsung heroes fighting cancer, infections, and even climate change! We wouldn't have beer, cheese, or yogurt without the microbial magic that’s been around for centuries. Microbiology isn’t just an academic field—it’s the hidden engine of our daily lives. So the next time you see a petri dish, remember it's not just a plate of "germs." It's a front-row seat to the drama of life itself. What’s your favorite microbe or microbiological discovery? Let’s geek out about the tiny things that make the biggest impact! Video credit: Tiktok - Labmica #Microbiology #Science #Microbiologist #STEM #Innovation #Biotech

Exciting news in the world of biotechnology! PCR (Polymerase Chain Reaction) continues to revolutionize the way we analyze DNA. With its ability to quickly and efficiently amplify DNA samples, PCR has become an indispensable tool in a wide range of fields, from medical diagnostics to forensic science. Using PCR, researchers can rapidly produce millions of copies of a specific DNA sequence, making it easier to study and analyze. This technology has played a crucial role in advancing our understanding of genetics and has led to breakthroughs in medicine, agriculture, and environmental science. As we continue to push the boundaries of what is possible in biotechnology, it's important to stay informed about the latest advancements in PCR and how they are shaping the future of DNA analysis. Let's keep the conversation going and stay updated on the latest developments in this fascinating field! ?? Popular hashtags to consider including in your content: #PCR #DNATechnology #Biotechnology #Genetics #DNAAnalysis #BiotechInnovation #PCRAdvancements #GenomicResearch #LaboratoryScience #MolecularBiology

?? My new story! Meet CARBONAra, a novel, AI-driven model designed to predict protein sequences from backbone scaffolds, incorporating complex molecular environments. It promises significant advancements in protein engineering and applications across various fields, including medicine ? and biotechnology ??. CARBONAra was developed by Lucien Fabrice Krapp and his colleagues in the group of Matteo Dal Peraro at EPFL. The awesome illustration below was made by Alexandra Banbanaste. #AI #artificialintelligence #proteindesign #proteinsynthesis #proteinsequencing #proteinbackbone #bioengineering #biotechnology #EPFL #EPFLlifesciences