Ovid Therapeutics的动态

Our mission is to improve the human relevance of biomedical research and develop alternative methods to animal testing. Three-dimensional bioprinting is used to generate organ models that are then used for various biomedical research applications. In addition to animal welfare, an advantage of this approach is that human cells are used, and the humanized models may have greater relevance to human disease than animal models. Our focus is on models for the lung and the liver. We use the bioprinted organ models to carry out infection studies. Furthermore, we develop cancer models. A particular strength of bioprinting is the opportunity to includes a vascular system to the organ model, which allows perfusion of the models.

Valproic acid-induced teratogenicity is driven by senescence and prevented by Rapamycin in human spinal cord and animal models

https://lnkd.in/eRVtis-m Valproic acid-induced teratogenicity is driven by senescence and prevented by Rapamycin in human spinal cord and animal models

A first-of-its-kind clinical trial may bring new hope for dogs suffering from epilepsy. Led by researchers at the University of Glasgow’s Small Animal Hospital in partnership with the Royal College of Surgeons in Ireland, the trial aims to treat severe epilepsy in dogs using a new medication, Ant-134. Early results have been promising, with some dogs showing a decrease in symptoms and an enhanced quality of life. Furthermore, initial results in mice showed prolonged seizure management without any side effects. Canine epilepsy is the most prevalent neurological disorder in dogs, causing severe and often lifelong symptoms and stress for both pets and their owners. While some cases can be controlled with medication, other dogs may respond poorly or not at all to treatments. Unfortunately, about one-third of dogs with epilepsy do not react positively to currently available anti-seizure drugs. Thanks to this research, this new treatment may eventually be able to offer relief to thousands of dogs impacted by this debilitating disease. You can learn more here: https://lnkd.in/dkytWyQg #AnimalResearch

Definition: xenograft - a tissue graft?or organ transplant?from a donor of a different species from the recipient. ? “All US transplants of animal organs into living humans… received FDA approval as a ‘compassionate use’, granted in narrow cases when a person’s life is at risk and there are no other treatments.” There is a great need for #xenotransplantation, and clinical trials would produce data on safety and efficacy. A robust #ViralSafety program is essential. https://lnkd.in/eD7afymn Having been in business since 1987, we have the expertise to guide you. Contact us for a consultation today. #ProtectingTomorrowsMedicinesToday ? https://lnkd.in/ekqQxXki

"Lymph nodes (LNs) are frequently the first sites of metastasis. Currently, the only prognostic LN assessment is determining metastatic status. However, there is evidence suggesting that LN metastasis is facilitated by the formation of a pre‐metastatic niche induced by tumour derived extracellular vehicles (EVs). Therefore, it is important to detect and modify the LN environmental changes. Earlier work has demonstrated that neutrophil extracellular traps (NETs) can sequester and promote distant metastasis. Here, we first confirmed that LN NETs are associated with reduced patient survival. Next, we demonstrated that NETs deposition precedes LN metastasis and NETs inhibition diminishes LN metastases in animal models. Furthermore, we discovered that EVs are essential to the formation of LN NETs. Finally, we showed that lymphatic endothelial cells secrete CXCL8/2 in response to EVs inducing NETs formation and the promotion of LN metastasis. Our findings reveal the role of EV‐induced NETs in LN metastasis and provide potential immunotherapeutic vulnerabilities that may occur early in the metastatic cascade" Su et. al. 2023 Tumour extracellular vesicles induce neutrophil extracellular traps to promote lymph node metastasis https://lnkd.in/e2gQS9ca

???Now Available On-Demand!??? You can now catch?Unleashing the Potential: Medium Chain Triglycerides in the Battle Against Canine Epilepsy?at your convenience! ?? We had over 2,000 registrations and more than 500 attendees tuning in live for this groundbreaking session sponsored by VetPlus. In this insightful webinar, we dive deep into the science of Medium-Chain Triglycerides (MCTs) and their potential role in managing canine epilepsy. Learn about how MCTs fuel brain function, influence seizure control, and the latest research that could transform epilepsy treatment. ?? Watch now to explore how diet and MCTs are reshaping veterinary neurology: https://lnkd.in/eAipABmX

?? New Publication Alert ?? Title: Exploring the #cardiovascular effects of hypertonic lactate: a systematic review of animal studies ?? Authors: Oskar Kj?rgaard H?rsdal ?? Keywords: #Metabolism, lactate, hypertonic, #inflammation, cardiovascular, animal studies Curious to know more? Dive into the article: https://lnkd.in/g2y7t3GB #ExplorMed

Dystonia and Paroxysmal Dyskinesias: Under-Recognized Movement Disorders in Domestic Animals? A Comparison with Human Dystonia/Paroxysmal Dyskinesia Involuntary hyperkinetic movement disorders that share common clinical features with different types of dystonia and paroxysmal dyskinesias in humans are described in dogs, horses, and cattle. While genetic analyses have shown that the currently recognized movement disabilities termed as CMD in cattle do not seem to represent dystonia, it has yet to be clarified if hyperkinetic movements in dogs and horses are dystonic in nature. As neurophysiological examinations in patients with dystonia show specific EMG patterns, this may help to clarify diagnosis. Since muscle cocontractions of antagonistic muscles and phasic tremulous and/or non-tremulous muscle activity represent the hallmarks of dystonia, these would help to distinguish between possible diagnoses in affected animals. Although attempts at treatment with GABAmimetic drugs like benzodiazepines in dogs may be effective in some cases, the outcomes are inconsistent. Except for disorders with clearly defined genetic causes, the origin and the mechanisms underlying of the described movement disorders in domestic animals remain mostly unknown. Therefore, further postmortem studies and genetic analysis to determine the underlying pathophysiology and genetics of these conditions are required.

Last week was held in Ghent, Belgium, ICARE 2024, the 6th International Conference on Avian, Herpetological, Exotic Mammal, Zoo and Wildlife Medicine. It was a real pleasure to present on this occasion, a study performed at Ecole Nationale Vétérinaire d'Alfort titled: Spontaneous mammary neoplasms in guinea pigs: 85 cases (2006-2022). This report investigates the prevalence and malignancy of mammary neoplasia in Guinea Pigs, but also the survival of affected animals. Our results show that males had a 20.3 times increased likelihood of exhibiting malignant mammary neoplasms compared to females and for each passing year, animals had a 2.1 increased risk of having a malignant rather than benign mammary neoplasm. No statistical difference was seen in survival between the different types of surgery and in between benign or malignant tumors. I thank all the co-authors who participated and dedicated a lot of their time to the achievement of this paper. For more informations, this article can now be found on open access in the Journal of Exotic Pet Medicine - https://lnkd.in/eKNtu7aM