OFD Life Sciences的动态

?? Check out this article ?? Some really interesting work here coming out of a Cheshire Lab. Taking initiative against the use of animal testing in Science by producing synthetic skin for use in testing of pharmaceutical and cosmetics!

? Prolonging drug half-life through ISOXTEND? VHH antibodies, or nanobodies, are powerful biological products with low production costs. However, they face a key challenge: short half-life in the bloodstream due to their small size. Isogenica, has developed ISOXTEND? to overcome this limitation. This technology extends the half-life of VHHs, broadening their therapeutic applications. ?? But there’s something even more exciting: #ISOXTEND? isn’t limited to human therapeutics. Thanks to its versatility, it’s been shown to work effectively across various animal species. Not only is this great news for pre-clinical development, but it also opens the door to innovations in veterinary medicine. Whether for companion animals like dogs or agricultural animals like cows, ISOXTEND? offers great potential for human and animal health. ?? Explore the full details in our poster: https://loom.ly/Drlv0Yw #VHH #Therapeutics #AnimalHealth #Preclinical

Thoughts on this? >> Charles River aims to use $500M to reduce animal testing >> Comment below! >>> lqventures.com #strategy #competitiveintelligence #marketing #healthcare #productmarketing #biotech #pharma #pharmaceutical

This is a great short video. It is fabulous to see the US #FDA is so ahead of the game using and understanding #organonachip technology. I see they are using the #EmulateBio #organchip in this video. If you want to understand more about these technologies, then see what we are doing with companies like Emulate at the #3RsCollaborative at https://3rc.org/mps/.

Good one. I would not use them for predictivity in a human whole system as one organ communicates with hundred organs in a human. I use them to DESIGN MORE INFORMED AND OPTIMAL CLINICAL TRIALS. I also do not like to use the phrase ORGAN ON A CHIP. It is a misnomer. The organoids / spheroids are not really organs. They may mimic some physiological functions but not all. For example, hepatocyte-like cells differentiated from iPSC still grow in cell culture, where as primary human hepatocytes obtained from humans do not grow in cell culture. At the eend of the day, these are more advanced 3D cell co-culture systems compared to 2D static cell cultures which were used for several decades.

Great short video from the FDA that highlights how #OrganOnAChip technology is helping to better predict the efficacy and safety of drugs in development, while also reducing animal testing.

GLP study update: Silo’s 4-week GLP study will evaluate a 28-day repeat intranasal dosing with a 14-day recovery. In a recent non-GLP small animal dose-ranging study conducted with AmplifyBio, SPC-15 demonstrated rapid absorption with good exposure over a 24-hour period, suggesting a simple once-per-day human intranasal dosing regimen. #BioPharma #ClinicalStudy https://bit.ly/3VWkMDZ

World Health Organization has released draft guidelines on the phasing out of animal tests for the quality control of biologicals products. It has been estimated that more than 10 million animals a year are used worldwide in biologicals development and that 80% of these animals are used for routine quality control and batch release tests of licensed products. Therefore, these guidelines have the potential to impact millions of animals. Find out more and submit your comments on the draft guidelines. https://lnkd.in/gkK_Ak5i

#Spay_And_Neuter Market Share Expected Huge Growth during 2023-2032 https://bit.ly/3KEJMZq #Spay and Neuter are #medical procedures performed on #animals, typically #dogs and cats, to #sterilize them and #prevent them from reproducing. Spay #refers to the #surgical removal of a #female animal's #reproductive organs, including the #ovaries, uterus, and fallopian #tubes. Spay-Neuter Assistance Program, Inc. Spay Neuter Network Spay-Neuter Action Project Mississippi Spay and Neuter Long Island Spay and Neuter #marketresearch #network #technologies #spayandneuter #pharmaceuticals #healthcareindustry ?

In this episode of the Ask the Expert video series, Susan J. Schniepp, Regulatory Compliance Associates, and Siegfried Schmitt, PhD, Parexel, discuss the new chapter, Chapter <86> Bacterial Endotoxins Test Using Recombinant Reagents. https://lnkd.in/ezuyef-W