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Cranberry Juice, Cranberry Tablets, or Liquid Therapies for Urinary Tract Infection: A Systematic Review and Network Meta-analysis PMID: 39030132 Study link: https://lnkd.in/gsth9xbA UTIs are a common reason for people to present to the doctor. It's estimated that 90% of UTIs were caused by bacteria resistant to at least one antibiotic. Cranberry has been shown to help with UTIs; however, there was concern whether it was the components in cranberry or whether the benefits came from increasing liquid intake. This study was a network meta-analysis that sought to answer whether cranberry compounds effectively prevented, managed, and treated UTIs. 18 RCTs and two non-RCTs were included in this review. Compared to the placebo liquid, cranberry juice lowered the rate of UTI by 27% with a moderate grade for the certainty of evidence. There was insufficient evidence of a difference in the rates of UTIs between cranberry tablets and no treatment, placebo, or cranberry liquid. When comparing rates of antibiotic use, cranberry juice had a 49% lower rate of antibiotic use compared to placebo. The use of cranberry compounds was associated with reduced prevalence of UTI symptoms. The dose of cranberry juice was between 125 and 300 ml daily. The authors concluded that cranberry juice and increased liquid intake work synergistically to help reduce UTIs and antibiotic use. The exact mechanism of cranberry compounds is unknown, but it is thought to be related to polyphenols called proanthocyanidins, which have antibacterial and antifungal properties. Have you tried cranberry juice to help with UTIs? Let us know below! #nimbushealthcare #nimbushealthclub #cranberry #uti #juice #infection

Urinary tract infections (UTIs) are common, uncomfortable, and embarrassing. They can also be deadly. These infections of the kidneys, bladder, or urethra affect about 1 in 10 men in their lifetimes and more than half of women. Untreated UTIs can cause a body-wide infection known as sepsis. An estimated 236,000 people globally die every year from UTIs. Most UTIs are fairly easy to treat with antibiotics. However, a quarter to a third of urinary tract infections (UTIs) are caused by drug-resistant bacteria. That makes them much more difficult to treat. There’s no easy test to tell medical professionals whether an infection will be easy to treat with readily available antibiotics, so they often have to make their best guess. Using the wrong antibiotic to treat any infection can delay recovery and help germs evolve drug resistance. Sweden-based Sysmex Astrego AB developed a test that works in 45 minutes to help determine what type of germ is causing a UTI and which antibiotic should be used to treat it. Challenge Works, which awards prizes to encourage solutions to hard problems in global health, climate, technology, and other areas, has awarded Sysmex Astrego the Longitude Prize to help the company develop and commercialize the test. “The winning test will be transformational for infection diagnosis and treatment, providing accurate antibiotic susceptibility results in 45 minutes – compared to the 2-3 day wait patients currently face,” Challenge Works says. In this episode of One World, One Health, Jasmin Major of Challenge Works explains why diagnostic innovations like this are so important. Give it a listen: https://lnkd.in/d9Ys8WwF #HealthInnovation #ChallengeWorks #LongitudePrize #UTI #MedicalTechnology #podcast

Early Strep A diagnosis can ensure prompt treatment and minimal spread of the infection ? Did you know that sore throat (acute pharyngitis) is one of the most common reasons for seeking medical attention in primary care? Although most cases of acute pharyngitis are caused by viruses, the most common bacterial cause for acute pharyngitis is Strep A (Streptococcus pyogenes), also known as GAS (Group A Streptococcus). ? GAS pharyngitis can occur in people of all ages, but it is most common among children between 5 to 15 years of age. Crowded conditions facilitate transmission, such as those for example in schools, and daycare centers. ? Early verification or exclusion of Strep A infection: ? Enables prompt antibiotic treatment, and minimal spread of the infection ? Helps to avoid inappropriate antibiotic use (when Strep A infection is excluded) ? GAS pharyngitis is diagnosed by rapid antigen detection test, such as QuikRead go Strep A, or by bacterial culture, and is treated with antibiotics. Fast and accurate QuikRead go Strep A test aids in early GAS detection and drives evidence-based treatment in point-of-care environment. https://lnkd.in/d8RasgMz #Aidian #youraidindiagnostics #StrepA #Streptococcuspyogenes #streptococcus #GAS #QuikReadgo #pointofcare #POCT #testbeforeprescribing

The statistics regarding healthcare-associated infections (HAI) are indeed concerning. It's unsettling to consider that a visit to the hospital for a minor health issue could result in a serious infection. Moreover, the apparent shortfall in investment for infectious diseases by both public and private sectors is disheartening, especially in light of the lessons we should have learned from the COVID pandemic. It's crucial to advocate for more attention and resources to be directed towards preventing HAIs and advancing infectious disease research and treatments' development. #InfectiousDiseases #HealthcareAssociatedInfections #drugDiscovery

Reflecting on the recent ESCMID - European Society of Clinical Microbiology and Infectious Diseases conference in Barcelona, the challenge of healthcare-associated infections (HAI) was a pivotal topic, emphasising the critical need for innovation and adherence to best practices in infection prevention. The European Centre for Disease Prevention and Control provides alarming statistics that highlight the gravity of the situation:?4.1 million cases?of healthcare-associated infections occur annually in Europe, leading to approximately?37,000 deaths. The economic burden is equally staggering, with direct costs estimated at?€7 billion. These infections not only pose a serious threat to patient safety but also have a profound impact on healthcare systems and economies. The rise of antimicrobial resistance exacerbates the challenge, as it limits treatment options and increases the risk of outbreaks. A previous World Health Organization's report about prioritisation of pathogens further illustrates the global spread of carbapenem resistance as well as Methicillin-resistant?Staphylococcus aureus?(MRSA), a major healthcare burden with high mortality rates and very limited treatment options, marking it as an urgent threat. The discussions at ESCMID underscored the urgency of this public health issue and the collective responsibility we share in combating it. As we continue to navigate this complex landscape, it is imperative that we support research and development for new antibiotics and implement robust infection control measures. Let us take the insights from the conference and the data provided by the ECDC to heart, and work together to drive change and improve patient outcomes. #ESCMID #Healthcare #InfectionPrevention #AntimicrobialResistance #HealthCareAssociatedInfections https://lnkd.in/dXRQafXb

3 Key Takeaways 1. The COVID-19 pandemic strained healthcare systems, leading to increased inappropriate antibiotic use and a peak in AR burden in 2021. 2. There is a pressing need for new antibacterial products, with only 97 in clinical development as of December 2023, and only 3 nearing market readiness. 3. The CDC has launched extensive public health initiatives to combat antimicrobial resistance, emphasizing the necessity for continued investment in infection control and monitoring. https://lnkd.in/eyFc3F4P

To mark the II UN General Assembly High-Level Meeting on #AntimicrobialResistance, EUROCAM stands as a proud supporter of the European Network on Infection Prevention and #AntimicrobialResistance (#ENIPAR) in a Call to Action. It's time to enhance the role of already available medical and digital technologies and promote innovative solutions, including integrative healthcare options. By reducing the need for antibiotics, improving patient outcomes, and promoting sustainable healthcare practices, we can strengthen the EU's response to #AMR and meet the 2030 targets. ? #UNGA79 #infectionprevention #healthcare #EUpolicy #IPC #PreventInfection #patientsafety

?? EHMA is proud to announce that we have joined the European Network for Infection Prevention and Antimicrobial Resistance (ENIPAR). As a multi-stakeholder platform, ENIPAR brings together healthcare professionals, patient groups, and academic experts to drive effective action on infection prevention and control, and to address the growing threat of antimicrobial resistance (AMR) across Europe. ?? ENIPAR has issued a Call to Action urging European and national policymakers to intensify efforts in reducing AMR-related mortality and inappropriate antibiotic use. The Call focuses on improving infection prevention measures, raising awareness, and ensuring access to medical technologies that support effective care. These goals are aligned with the EU's target of a 10% reduction in AMR deaths and a 20% reduction in inappropriate antibiotic use by 2030. ?? At EHMA, we fully support this Call to Action. Together with ENIPAR, we are advocating for policies that prioritise infection prevention, prudent antibiotic use, and improved healthcare resilience to create a safer and healthier future for all. You can read the full Call to Action in the attachment. #EHMA #ENIPAR #CallToAction #InfectionPrevention #AMR #HealthcareResilience European Commission European Centre for Disease Prevention and Control (ECDC) European Medicines Agency Cristian Busoi Dolors Montserrat Sandra Gallina Lorena Boix Alonso European Public Health Alliance (EPHA) MedTech Europe The European Association of Hospital Pharmacists (EAHP) EUROCAM EWMA ? European Wound Management Association IPOPI - International Patient Organisation for Primary Immunodeficiencies

#Urinarytractinfection (#UTI) is an infection caused by pathogenic microorganisms invading the urinary system (including kidneys, ureters, bladder and urethra). Escherichia coli is the most common pathogen, accounting for about 80% of all cases. Other common pathogens include Klebsiella, Enterococcus and Proteus. Women are at much higher risk of UTI than men because women have a shorter urethra, which makes it easier for pathogens to enter the bladder through the urethra. In addition, the elderly, pregnant women, immunocompromised individuals, and diabetic patients are all high-risk groups for UTI. Treatment of UTI usually relies on #antibiotics, but in recent years, antibiotic resistance (#DrugResistance) has become a major problem in the treatment of UTI worldwide. Due to the abuse or improper use of antibiotics, the number of resistant strains continues to increase, especially the resistance of common pathogens such as Escherichia coli. Therefore, it is particularly important to ensure that pathogens and their resistance characteristics can be accurately identified before treatment through #rapiddiagnosis and #moleculardetection technology.

A potentially deadly bacterial infection called?streptococcal toxic shock syndrome, or STSS. -Staphylococcal toxic shock syndrome is a rare complication of Staphylococcus aureus infection in which bacterial toxins act as superantigens, activating very large numbers of T cells and generating an overwhelming immune-mediated cytokine avalanche that manifests clinically as fever, rash, shock, and rapidly progressive multiple organ failure, often in young, previously healthy patients. The syndrome can occur with any site of S. aureus infection, and so clinicians of all medical specialties should have a firm grasp of the presentation and management. *The 'flesh-eating bacteria' can lead to rapid tissue destruction and organ *failure The bacteria spreads through respiratory droplets, direct contact, and improperly handled food Basic hygiene and immediate medical attention are crucial for prevention and treatment In Japan, cases of flesh-eating bacteria have reached a record high. -The outbreak of Streptococcal Toxic Shock Syndrome (STSS), also called the "flesh-eating bacteria", has affected almost 1,000 people from the beginning of the year to June 2, according to the National Institute of Infectious Diseases. -The disease has a mortality rate of 30% and can become fatal within 48 hours of infection.