Interventional Orthobiologics Foundation的动态

An IL-2 mutein increases regulatory T cell suppression of dendritic cells via IL-10 and CTLA-4 to promote T cell anergy https://lnkd.in/gurVKuUt

Very interesting to read, hematopoietic stem and progenitor cells (HSPCs) prevent macrophages from engulfing via TLR3 (Sensing repetitive element-associated double-stranded RNA)-B2M axis ?????? https://lnkd.in/gsFUpbvX

????♀?Playing detective with rare transcripts? Meet the unicorns ???? SuperScript IV CellsDirect cDNA Synthesis Kit and SuperScript IV Single Cell/Low-Input cDNA PreAmp Kit, which are highly sensitive and designed for low-input samples, such as 3D spheroids, primary cells, and single cells. The bonus: Skip RNA isolation; synthesize cDNA directly from cell lysates. ?? Read our application note: Direct cDNA synthesis from single spheroids and primary cell samples - https://lnkd.in/gPUUDjKz #ilovemolbio #cDNAsynthesis

????♀?Playing detective with rare transcripts? Meet the unicorns ???? SuperScript IV CellsDirect cDNA Synthesis Kit and SuperScript IV Single Cell/Low-Input cDNA PreAmp Kit, which are highly sensitive and designed for low-input samples, such as 3D spheroids, primary cells, and single cells. The bonus: Skip RNA isolation; synthesize cDNA directly from cell lysates. ?? Read our application note: Direct cDNA synthesis from single spheroids and primary cell samples - https://lnkd.in/gPUUDjKz #ilovemolbio #cDNAsynthesis

????♀?Playing detective with rare transcripts? Meet the unicorns ???? SuperScript IV CellsDirect cDNA Synthesis Kit and SuperScript IV Single Cell/Low-Input cDNA PreAmp Kit, which are highly sensitive and designed for low-input samples, such as 3D spheroids, primary cells, and single cells. The bonus: Skip RNA isolation; synthesize cDNA directly from cell lysates. ?? Read our application note: Direct cDNA synthesis from single spheroids and primary cell samples - https://lnkd.in/gPUUDjKz #ilovemolbio #cDNAsynthesis

tRNA structure A transfer RNA (abbreviated tRNA and formerly referred to as sRNA, for soluble RNA) is an adaptor molecule composed of RNA, typically 76 to 90 nucleotides in length, that serves as the physical link between the mRNA and the amino acid sequence of proteins. Youtube video: https://lnkd.in/dm4B4pM5 #nikolaysgeneticslessons

CICS-UBI PUBLICATIONS A new approach for extracellular RNA recovery from Rhodovulum sulfidophilum https://lnkd.in/drqp27ps

Noninvasive preeclampsia prediction using plasma cell–free RNA signatures - cfRNA characterization and DEGs in preterm PE https://ow.ly/FKvt50Q4teP

Comparison of the mechanistic action of ASO, siRNA and aptamer. (A) ASO has two antisense mechanisms by obstruction of target mRNA leading to cease translation and RNase mediated degradation of target mRNA. (B) siRNA mediates mRNA degradation involving Dicer and RISC complex containing Ago, RNase H like endonuclease which cleaves target mRNAs that are complementary to guide RNA. (C) Aptamer can be activated by folding into 3D structures and can bind to a variety of targets therefore achieving broad applications. https://lnkd.in/gQisEMBJ