3i - Intelligent Imaging Innovations的动态

Incredibly proud to share my first PhD publication and the work Alex Tang and I have been doing over the past few years. Using spatial transcriptomics, we've mapped how repetitive transcranial magnetic stimulation (rTMS) is capable of affecting multiple neural plasticity mechanisms across different brain regions - even down to individual cortical layers! If you are interested in rTMS, check out the full paper here: https://lnkd.in/gxckVG6r

Check out this groundbreaking AI-driven 3D brain tissue map from Harvard and Google in this HPCwire article. Witness how this collaboration is reshaping neuroscience, revealing the brain's mysteries as never before. https://bit.ly/4bS5s0r #LifeSciences #GigaIO #HPCwire

Precision Neuroscience, co-founded by neurosurgeon Benjamin Rapoport and CEO Michael Mager, has secured $102 million in Series C funding to advance its minimally invasive brain-computer interface technology. The company’s Layer 7 Cortical Interface aims to help patients control digital devices with their thoughts—without penetrating the brain—setting it apart from Neuralink, co-founded by Rapoport and Elon Musk. As the competition intensifies, Precision’s physician-led approach focuses on safety, scalability, and solving real-world medical challenges today. Read the complete article here: https://lnkd.in/gNZsYyDq

To understand the complexity of the brain is to realize our current AI efforts are only a kid on a tricycle, pedaling to the moon. Key article quote: "The word 'fragment' is ironic," says neuroscientist Jeff Lichtman of Harvard University. "A terabyte is, for most people, gigantic, yet a fragment of a human brain – just a miniscule, teeny-weeny little bit of human brain – is still thousands of terabytes." --------- We'll get there, but we have a lot of work, most of it not engineering, yet to do. #neuroscience #brain #complexity #notyetAI https://lnkd.in/ehX7XE6u

Connections between neurons can be mapped by acquiring and analysing electron microscopic brain images. In recent years, this approach has been applied to chunks of brains to reconstruct local connectivity maps that are highly informative1,2,3,4,5,6, but nevertheless inadequate for understanding brain function more globally. Here we present a neuronal wiring diagram of a whole brain containing 5?×?107 chemical synapses7 between 139,255 neurons reconstructed from an adult female Drosophila melanogaster8,9. The resource also incorporates annotations of cell classes and types, nerves, hemilineages and predictions of neurotransmitter identities10,11,12. Data products are available for download, programmatic access and interactive browsing and have been made interoperable with other fly data resources. We derive a projectome—a map of projections between regions—from the connectome and report on tracing of synaptic pathways and the analysis of information flow from inputs (sensory and ascending neurons) to outputs (motor, endocrine and descending neurons) across both hemispheres and between the central brain and the optic lobes. Tracing from a subset of photoreceptors to descending motor pathways illustrates how structure can uncover putative circuit mechanisms underlying sensorimotor behaviours. The technologies and open ecosystem reported here set the stage for future large-scale connectome projects in other species. https://lnkd.in/dYhFNUzs

New research reveals that traditional resting-state fMRI (rsfMRI) may overlook certain neural activities, offering a fresh perspective on how the brain's regions coordinate during rest. Researchers compared blood flow data from rsfMRI with direct neural recordings, discovering that some brain activities, termed “invisible signals,” don’t align with blood flow changes. This challenges the conventional view that rsfMRI fully captures brain activity and suggests that unseen signals may play a larger role in resting-state networks. Overall , this study proposes that these findings may apply to human brains, potentially reshaping brain imaging interpretation. Which will help lead to more precise understanding of brain networks. Learn more: https://lnkd.in/gwjcTpiF One love #brain #network #neural #activity

?? Advancing Brain-Computer Interface (BCI) Technologies in Neurology ?? In an era where neuroscience meets digital innovation, brain-computer interfaces (BCIs) hold transformative potential. Pioneering research by Harvard’s Craig Mermel and Ben Rapoport is driving BCI advancements to connect neural activity directly with digital systems—especially impactful for patients with severe motor impairments. From enabling autonomy in paralysis cases to reshaping patient data ethics, BCIs are opening doors to ethical, impactful neuromodulation. For those interested in the nuances of this cutting-edge work, dive deeper here ?? https://lnkd.in/ewhEQG3a

Upcoming Webinar Announcement Join us on December 17, 2024, from 10:00 AM - 11:00 AM EST for a webinar with Dr. Josh L. Morgan, Assistant Professor in the Departments of Ophthalmology, Neuroscience, and Biomedical Engineering. Dr. Morgan will discuss cutting-edge approaches for serial vibratome sectioning and correlated light and electron microscopy to study the synaptic architecture of neural circuits. His research focuses on the retina and lateral geniculate nucleus (LGN), providing insights into how neural networks develop and process visual information. Key Topics: Techniques for sectioning whole mouse brains using vibratome technology Correlating light microscopy with 3D electron microscopy for detailed brain mapping Understanding synaptic connectivity and its role in visual processing Applications of advanced imaging in neural development and connectivity Register to learn more about these innovative techniques and their applications in neuroscience research. Register for free here: https://lnkd.in/eVqwTNbd #Neuroscience #BrainMapping #ElectronMicroscopy #NeuralCircuits #ScientificWebinar #PrecisionaryInstruments #compresstome #microtomes #vibratingmicrotomes #vibratomes #tissuesectioning #precisioncuttissuesslices #tissueslicing #laboratoryequipment #labsolutions

Who watched the Neuralink update last week??♀?? Check out my latest piece in BioPharmaTrend.com to find out who else is out there in the field of invasive, restorative BCIs apart from Elon;) Link in the comments. Shout-out to CereGate, INBRAIN Neuroelectronics, Precision Neuroscience, Axoft, Paradromics Inc., ONWARD Medical for their fabulous R&D, and to Andrii Buvailo, Ph.D. for creating such a great news platform!

Dr. Jeff Lichtman and his team at Harvard University, in collaboration with Google, created the most detailed map of human brain tissue using a 1 cubic millimeter sample containing 57,000 cells and 150 million synapses, generating 1,400 terabytes of data. The project involved slicing the tissue into nanometer-thin sections, staining them, and capturing 300 million images, which Google processed using AI to build a 3D interactive model. This unprecedented dataset, now available online, aims to advance our understanding of the brain's architecture and could reveal insights into various medical conditions, with future plans to map a mouse brain and potentially an entire human brain. #Neuroscience #BrainMapping #GoogleAI